21 August 2015:
CNBP researchers Prof. Dayong Jin and Dr. Yong Liu feature on a recently released publication from Scientific Reports published by the Nature Publication Group.
The paper titled “Multifunctional luminescent nanomaterials from NaLa(MoO4)2:Eu3+/Tb3+ with tunable decay lifetimes, emission colors, and enhanced cell viability”, can be downloaded in its entirety.
Abstract: A facile, but effective, method has been developed for large-scale preparation of NaLa(MoO4)2 nanorods and microflowers co-doped with Eu3+ and Tb3+ ions (abbreviated as: NLM:Ln3+). The as-synthesized nanomaterials possess a pure tetragonal phase with variable morphologies from shuttle-like nanorods to microflowers by controlling the reaction temperature and the amount of ethylene glycol used. Consequently, the resulting nanomaterials exhibit superb luminescent emissions over the visible region from red through yellow to green by simply changing the relative doping ratios of Eu3+ to Tb3+ ions. Biocompatibility study indicates that the addition of NLM:Ln3+ nanomaterials can stimulate the growth of normal human retinal pigment epithelium (ARPE-19) cells. Therefore, the newly-developed NaLa(MoO4)2 nanomaterials hold potentials for a wide range of multifunctional applications, including bioimaging, security protection, optical display, optoelectronics for information storage, and cell stimulation.
Authors: Mei Yang, Youlong Liang, Qingyuan Gui, Bingxin Zhao, Dayong Jin, Mimi Lin, Lu Yan, Hongpeng You, Liming Dai, and Yong Liu.
10 August 2015:
CNBP researchers Prof. Dayong Jin and Dr. Yong Liu feature on a newly published paper titled, “Multifunctional chitosan/polyvinyl pyrrolidone/45S5 Bioglass® scaffolds for MC3T3-E1 cell stimulation and drug release.” The paper was released in the journal, ‘Materials Science and Engineering C: Materials for Biological Applications.’
Abstract: Novel chitosan–polyvinyl pyrrolidone/45S5 Bioglass® (CS-PVP/BG) scaffolds were prepared via foam replication and chemical cross-linking techniques. The pristine BG, CS-PVP coated BG and genipin cross-linked CS-PVP/BG (G-CS-PVP/BG) scaffolds were synthesized and characterized in terms of chemical composition, physical structure and morphology respectively. Resistance to enzymatic degradation of the scaffold is improved significantly with the use of genipin cross-linked CS-PVP. The bio-effects of scaffolds on MC3T3-E1 osteoblast-like cells were evaluated by studying cell viability, adhesion and proliferation. The CCK-8 assay shows that cell viability on the resulting G-CS-PVP/BG scaffold is improved obviously after cross-linking of genipin. Cell skeleton images exhibit that well-stretched F-actin bundles are obtained on the G-CS-PVP/BG scaffold. SEM results present significant improvement on the cell adhesion and proliferation for cells cultured on the G-CS-PVP/BG scaffold. The drug release performance on the as-synthesized scaffold was studied in a phosphate buffered saline (PBS) solution. Vancomycin is found to be released in burst fashion within 24 h from the pristine BG scaffold, however, the release period from the G-CS-PVP/BG scaffold is enhanced to 7 days, indicating improved drug release properties of the G-CS-PVP/BG scaffold. Our results suggest that the G-CS-PVP/BG scaffolds possess promising physicochemical properties, sustained drug release capability and good biocompatibility for MC3T3-E1 cells’ proliferation and adhesion, suggesting their potential applications in areas such as MC3T3-E1 cell stimulation and bone tissue engineering.
Qingqing Yao, Wei Li, Shanshan Yu, Liwei Ma, Dayong Jin, Aldo R. Boccaccini, Yong Liu, Materials Science and Engineering: C, 2015, 56, 473-480.
The full article can be downloaded here: http://www.sciencedirect.com/science/article/pii/S092849311530179X
4 July 2015:
Dr. Yong Liu, CNBP Research Fellow, gave an invited talk at the inaugural International Workshop on Thin-films for Electronics, Electro-Optics, Energy and Sensors, held in Suzhou, China, July 4-6, 2015.
Dr. Liu’s talk, “One-step synthesis of polymers modified graphene as high-performance catalysts”, was very well received.
The Workshop, hosted by the University of Dayton’s China Institute and SPIE (The International Society for Optics and Photonics), is focused on the exchange of technical knowledge as well as the boosting of technical and educational collaboration activities within the thin-film research community.
More information about the Workshop is available via: https://www.udayton.edu/engineering/centers/cetrase/tfe3s/
8 June 2015:
CNBP researcher Yong Liu features on a newly published paper titled ‘Multifunctional glucose biosensors from Fe3O4 nanoparticles modified chitosan/graphene nanocomposites’.
ABSTRACT: Novel water-dispersible and biocompatible chitosan-functionalized graphene (CG) has been prepared by a one-step ball milling of carboxylic chitosan and graphite. Presence of nitrogen (from chitosan) at the surface of graphene enables the CG to be an outstanding catalyst for the electrochemical biosensors. The resulting CG shows lower ID/IG ratio in the Raman spectrum than other nitrogen-containing graphene prepared using different techniques. Magnetic Fe3O4 nanoparticles (MNP) are further introduced into the as-synthesized CG for multifunctional applications beyond biosensors such as magnetic resonance imaging (MRI). Carboxyl groups from CG is used to directly immobilize glucose oxidase (GOx) via covalent linkage while incorporation of MNP further facilitated enzyme loading and other unique properties. The resulting biosensor exhibits a good glucose detection response with a detection limit of 16 μM, a sensitivity of 5.658 mA/cm2/M, and a linear detection range up to 26 mM glucose. Formation of the multifunctional MNP/CG nanocomposites provides additional advantages for applications in more clinical areas such as in vivo biosensors and MRI agents.
Wenjing Zhang, Xiaojian Li, Ruitao Zou, Huizi Wu, Haiyan Shi, Shanshan Yu, and Yong Liu, Scientific Reports, 2015, 5, 11129. DOI: 10.1038/srep11129.
The full article can be downloaded here: http://www.nature.com/srep/2015/150608/srep11129/full/srep11129.html
4 May 2015:
A new Review paper has been published by CNBP researcher Dr Yong Liu.
ABSTRACT: In the past decades, great efforts have been developed for neurobiologists and neurologists to restore nervous system functions. Recently much attention has been paid to electrical stimulation (ES) of the nervous system as a potential way to repair it. Various conductive biocompatible materials with good electrical conductivity, biocompatibility, and long-term ES or electrical stability have been developed as the substrates for ES. In this review, we summarized different types of materials developed in the purpose for ES of nervous system, including conducting polymers, carbon nanomaterials and composites from conducting polymer/carbon nanomaterials. The present review will give our perspective on the future research directions for further investigation on development of ES particularly on the nerve system.
Electroactive biocompatible materials for nerve cell stimulation, (Review), M. Yang, Y. Liang, Q. Gui, J. Chen, and Y. Liu; 31 March 2015, Vol: 2,Page: 042001. DOI:10.1088/2053-1591/2/4/042001.
The full article can be downloaded: http://iopscience.iop.org/2053-1591/2/4/042001/
29 April 2015:
Dr Yong Liu has recently joined the CNBP team, as the ‘Qianjiang Scholar and Distinguished Professor of Zhejiang Province’, a joint appointment with the Wenzhou Medical University in China. He received his PhD from the ARC Centre of Excellence for Electromaterials Science (ACES) from the University of Wollongong. Thereafter, he continued his research at the University of Dayton and Case Western Reserve University before moving back to China. He has won the ‘2011 Scopus Young Research Award in Life Sciences of China’ and will be working with Prof. Dayong Jin at the CNBP Macquarie Node in the area of hybrid nanomaterials for multimodal bioimaging and biosensing.
2 April 2015:
CNBP researcher Dr Yong Liu has undertaken a visit to the Ningbo Institute of Materials Terchnology and Engineering (NIMTE), Chinese Academy of Sciences. Discussing potential future collaborations on nanoscale biomedical devices, Dr Liu also gave a talk titled ‘Multifunctional Nanomaterials for Biomedical Applications’. The visit took place April 2nd 2015.