Tag Archives: SciCommunity

OCT probe talks

12 February 2017:

Dr Jiawen Li, CNBP researcher, has given a number of invited talks, on her ongoing work with optical coherence tomography (OCT) and fiber-optic needle probes.

Her talks were focused on addressing the penetration-depth limitation of optical imaging through the development of miniaturised fibre-optic probes that may be inserted deep into the body.

Representative technologies and their ex vivo and in vivo applications were presented by Jiawen at both the Wellman Center for Photomedicine at Harvard Medical School (HMS) as well as at Polytechnic Montreal.

She saw great value in both visits, noting:

“I first visited the Wellman Center for Photomedicine (Feb 6th-7th), where I gave a talk, and met with Dr. Melissa Suter and Prof. Brett Bouma and their postdoctoral teams. Researchers there also gave me a tour of their laboratories. They showed me prototypes that they had made for clinical applications and shared with me their insights as to how to achieve successful and enhance efficient collaborations with clinicians. Attendees at my talk were very interested in our work on smart needles for safer and more effective brain surgery and on fabricating miniaturized lenses by the 3D printer at CNBP RMIT node, a project that is supported by a CNBP travel grant. Potential future collaborations were also explored.”

“At Polytechnic Montreal (Feb 8th-10th), I met with A/Prof. Caroline Boudoux, a collaborator on our fluorescence-OCT project, as well as postdoctoral researchers of A/Prof. Frederic Leblond. I visited both A/Prof. Leblond’s laboratory and A/Prof. Boudoux’s spin-out company Castor Optics. A technical meeting was held, where we discussed solutions to overcoming technical challenges in our current design. This visit strengthened our existing collaboration.”

A busy time for Jiawen, she also managed to fit in an oral presentation at the SPIE Photonics West 2017 Conference on January 28th , 2017. Her presentation was titled, “Flexible OCT needle probes for image-guided endoscopic tissue aspiration.”

 

CNBP-ANSTO workshop

CNBPlogoSquare8 December 2016:

CNBP’s Macquarie University node hosted researchers from the Australian Nuclear Science and Technology Organisation (ANSTO) at a highly successful full day workshop held on the 8th December, 2016.

The workshop was an opportunity to showcase current imaging and sensing research from both organisations, to stimulate discussion and to see where collaboration opportunities might potentially lie in the future.

In a full and impressive program, ANSTO team members and their research topics presented included:

1. Marie-Claude Gregoire – who provided a team overview and introduction
2. Ben Fraser – multi-modal probes
3. Paul Callaghan – in vivo & post mortem multi-modality imaging
4. Mitra Safavi-Naeni – imaging quantification
5. Catriona Wimberley – in vivo kinetic modelling

CNBP researchers Arun Dass, Guozhen Liu, Helen Xu, Wei Deng, Nima Sayyadi, Andrew Care, Nicole Cordina, Varun Sreenivasan, Lianmei Jiang and Ayad Anwer also delivered talks on their areas of research and expertise.

Below – workshop attendees ready for an exciting day of presentations and discussion!

OLYMPUS DIGITAL CAMERA

 

Director attends ANS 2016 in Hobart

Mark Hutchinson_1_low_sq7 December 2016:

Professor Mark Hutchinson (Director, CNBP) attended the Australasian Neuroscience Society (ANS 2016) Conference in Hobart on 6 and 7 December 2016 where he presented a talk entitled “The ‘Toll’ of Knowing You are Sick: Microglial Innate Immune Signalling as a Key Contributor to Sex Differences in Pain and Analgesia”.

The Director also chaired a session entitled “Integrated Approaches to Treating Pain and Other Diseases of the Central Nervous System: From Targets to Circuits and Beyond”.

Director speaks at joint meeting

Mark Hutchinson_1_low_sq5 December 2016:

Professor Mark Hutchinson (Director, CNBP) was invited to speak at the joint Australian Physiological Society (AuPS) and Australian Society for Biophysics (ASB) meeting held in Adelaide on 5 December 2016.

He participated in the symposium “Thinking Small: Seeing Biological Processes with Nanotechnology and Photonics”.

His talk was titled, “Using Light to Measure the Previously Unmeasurable Within the Central Nervous System.”

Centre researchers at Biosensor Symposium

guozhen_liu30 November 2016:

CNBP Research Fellows, Associate Professor Guozhen Liu (pictured), Dr Lindsay Parker and Dr Sabrina Heng have undertaken talks at the School of Biomedical Sciences at the University of Melbourne as part of a Biosensor Symposium, Wednesday 30th November, 2016.

Talks were as follows:

Guozhen Liu – Biophotonic Tools for Cytokine Sensing: From an on-cell surface ELISA to a spatial ELISA device.

Lindsay Parker – Biosensors and glycoproteins: linking nanoscience to neuroscience.

Sabrina Heng – Reversible Sensing with a Flip of the Switch.

The symposium shone a  spotlight on multidisciplinary research into developing, applying and using biosensors for biomedical sciences.

Deputy Director presents at Wagga Wagga

Ewa Goldys Low Res Edit 015929 November 2016:

CNBP Deputy Director Prof Ewa Goldys has given a talk at the School of Biomedical Sciences, Charles Sturt University, Wagga Wagga on her research success “A Eureka Moment for Cell Colour Technology.”

The talk results from Prof Goldys being awarded the recent Australian Museum Eureka Prize for ‘Innovative Use of Technology’.

Prof Goldys, together with Dr Martin Gosnell, developed a hyperspectral imaging technique that allows for the successful extraction of specific biomolecular information hidden in fluorescent colour signatures of living cells and tissues.

The talk examined the technology and the real world translational outcomes that will result from this exciting area of study that will support clinicians in making improved diagnosis and health decisions for patients.

 

NeuRA Invited Seminar Series

Ewa Goldys Low Res Edit 015925 November 2016:

Professor Ewa Goldys, Deputy Director of the CNBP, has given an invited talk at the Neuroscience Research Australia (NeuRA) Invited Lecture series, 25th November 2016, Sydney.

The talk was titled “A Eureka moment for cell colour technology” and explored the research behind Prof Goldys and her success in being awarded the 2016 Australian Museum Eureka Prize for ‘Innovative Use of Technology’.

Professor Goldys and her team were recognised for their innovative colour-focused research (and pioneering hyperspectral imaging technique), able to distinguish between healthy and diseased cells, in areas as diverse as embryology, neurodegeneration, cancer and diabetes.

Real-world translational outcomes that will result from this exciting area of study, that will support clinicians in making improved diagnosis and health decisions for patients, was also discussed.

The NeuRA lecture series attracts leading national and international researchers from all fields of neuroscience.

 

PLGA nanocomposites developed for PDT of cancer cells

staff photos for Centre of Excellence in Nanoscale Biophotonics (CNBP)24 November 2016:

In this latest paper, CNBP researchers (lead author Wei Deng pictured left) developed PLGA nanocomposites by incorporating a photosensitizer, verteporfin and gold nanoparticles into the polymeric matrix and utilised them for enhanced photodynamic therapy of cancer cells.

Journal: RSC Advances.

Title: PLGA nanocomposites loaded with verteporfin and gold nanoparticles for enhanced photodynamic therapy of cancer cells.

Authors: Wei Deng, Zofia Kautzka, Wenjie Chen and Ewa M Goldys.

Abstract: In this paper, PLGA nanocomposites were developed by incorporating a photosensitizer, verteporfin and gold nanoparticles into the polymeric matrix and utilised for enhanced photodynamic therapy of cancer cells. Both enhanced fluorescence and O2 generation from verteporfin were observed in this new formulation under both 425 nm LED and 405 nm laser illumination. A maximum enhancement factor of 2.5 for fluorescence and 1.84 for O2 generation was obtained when the molar ratio of gold : VP was 5:1 and excited at 425 nm, compared with PLGA doped with verteporfin alone. The experiment results could be explained by the local electric field enhancement of gold nanoparticles. Furthermore, improved therapeutic efficacy in human pancreatic cancer cells, PANC-1, was also demonstrated by using this new formulation following light exposure, indicating the utility of these nanocomposites for enhanced photodynamic therapy.

The paper is accessible online.

Key player in GPCR research to visit CNBP

sanam Mustafa14 November 2016:

Dr Sanam Mustafa has organised the visit to CNBP of a key player in the field of G protein-coupled receptors research, Professor Graeme Milligan.

The visit will take place in Adelaide, Friday 25th November 2016 – If you would like to chat with Professor Milligan please contact Dr Sanam Mustafa via email (sanam.mustafa@adelaide.edu.au).

Professor Milligan’s main research group centres on the function, structure and regulation of G protein-coupled receptors (GPCRs) and their interacting proteins. He has published some 500 peer-reviewed articles on these topics. His research has been cited more than 24,000 times. Professor Graeme Milligan graduated with a Bachelor of Science in Biochemistry from the University of Birmingham. He went on to do his PhD at the University of Nottingham. Graeme was elected to the Fellowship of the Royal Society of Edinburgh in 1998 and, amongst various honours, was the recipient of the Ariens Award for pharmacology from the Dutch Pharmacological Society in 2006 and the JR Vane Medal for Pharmacology from the British Pharmacological Society in 2016. Professor Milligan is currently a Professor of Molecular Pharmacology, Dean of Research, College of Medical, Veterinary and Life Sciences and a Gardiner Professor of Biochemistry at the University of Glasgow. Professor Milligan is also a non-executive director and co-founder of the company Caldan Therapeutics which is searching for novel treatments for type II diabetes.

Professor Milligan will first present a keynote address at the Adelaide Pharmacology Group Meeting at the National Wine Centre on Friday 25th, followed by an afternoon tour of CNBP and one-to-one meetings.

 

 

Visit to Hoshi University by Director

Mark Hutchinson_1_low_sq7 November 2016:

The CNBP Director (Professor Mark Hutchinson) visited the Department of Pharmacology at Hoshi University on the 7th November 2016 where he met with Professor Minoru Narita, provided a 10 minute introduction speech to undergraduate student lectures and provided a seminar to senior researchers and graduate students.

Professor Hutchinson’s talk was titled, “The role of toll-like receptors as key modulators of chronic pain: similarities and differences between male and females.”