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A review paper by CNBP researchers (lead author Sameera Iqbal pictured) reports on the examination of cellular glycan surfaces in the central nervous system and links to disorders and disease such as Alzheimer’s disease, multiple sclerosis and more.
Journal: Biochemical Society Transactions.
Publication title: Understanding cellular glycan surfaces in the central nervous system.
Authors: Sameera Iqbal, Mina Ghanimi Fard, Arun Everest-Dass, Nicolle H. Packer, Lindsay M. Parker.
Abstract: Glycosylation, the enzymatic process by which glycans are attached to proteins and lipids, is the most abundant and functionally important type of post-translational modification associated with brain development, neurodegenerative disorders, psychopathologies and brain cancers. Glycan structures are diverse and complex; however, they have been detected and targeted in the central nervous system (CNS) by various immunohistochemical detection methods using glycan-binding proteins such as anti-glycan antibodies or lectins and/or characterized with analytical techniques such as chromatography and mass spectrometry. The glycan structures on glycoproteins and glycolipids expressed in neural stem cells play key roles in neural development, biological processes and CNS maintenance, such as cell adhesion, signal transduction, molecular trafficking and differentiation. This brief review will highlight some of the important findings on differential glycan expression across stages of CNS cell differentiation and in pathological disorders and diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, multiple sclerosis, amyotrophic lateral sclerosis, schizophrenia and brain cancer.
Sameera Iqbal, CNBP PhD student at Macquarie University has been awarded a certificate and cash prize for her poster presentation at the Australasian Glycoscience Symposium at the Lorne Proteomics Conference, 2 Feb, 2018.
Her poster detailed the following work –
‘PolySialic Acid (PolySia) is an α2-8-linked sialic acid chain present on cell surfaces in embryonic brains. Changes in polysialylation pattern are reported to be associated with immune defense and inflammation in the CNS. Opioids such as Morphine-3-Glucuronide (M3G) (metabolite of morphine) activates neuroinflammation in a manner parallel to Lipopolysaccharide (LPS), compromising opioid-induced analgesia. In this study, morphine (Morphine-3-glucuronide) was hypothesized to affect the polySia expression in neurons and astrocyte cell lines. It was observed that PolySia expression was significantly increased in neurons following LPS and M3G stimulation.’
Well done Sameera!
We welcome CNBP’s newest PhD candidate to Macquarie University, Sameera Iqbal.
Sameera, supervised by CNBP Chief Investigator Nicolle Packer, is working on finding a selective bioactive-peptide that will bind to Polysialic Acid, for use in imaging in the brain. Her PhD is titled, “Imaging Polysialic Acid Using Selective Bioactive-Peptides.”
She completed a Bachelor of Biochemistry and Biotechnology from North South University in Dhaka Bangladesh in the year 2012. Then undertook a Master of Research degree in Chemistry and Biomolecular Science at Macquarie University. Here she gained expertise in the field of stem cell research, specifically trying to evaluate the effect of labeling stem cells with nanoparticles.
Welcome to the CNBP team Sameera!