17 July 2019:
3D printing of titanium has made patient-specific orthopaedic implants possible, promising to dramatically improve many people’s quality of life.
But, despite the huge potential, there are still significant problems to overcome, particularly in how the implants integrate with human tissue and bone.
Associate Professor Kate Fox from RMIT University in Melbourne, an Associate Investigator with the CNBP, led the team which, in a previous study, showed that a thin film coating of diamond could provide a better surface for cells to interact.
A new paper, Engineering the Interface: Nanodiamond Coating on 3D-Printed Titanium Promotes Mammalian Cell Growth and Inhibits Staphylococcus aureus Colonization expands on that work.
It describes how applying a nanodiamond (ND) coating on to the 3D printed titanium increased the cell density of both skin bone cells after three days of growth compared to the uncoated 3D printed titanium.
The study also showed an 88% reduction of Staphylococcus aureus – or Golden Staph – adherence to ND-coated substrates compared to those without.
This study, whose lead author is Aaquil Rifai, from RMIT, paves a way to create antifouling structures for biomedical implants.
You can read the paper here.
Journal: ACS Applied Materials & Interfaces
Publication Title: Engineering the Interface: Nanodiamond Coating on 3D-Printed Titanium Promotes Mammalian Cell Growth and Inhibits Staphylococcus aureus Colonization
Authors: Aaqil Rifai*, Nhiem Tran, Philipp Reineck, Aaron Elbourne, Edwin Mayes, Avik Sarker, Chaitali Dekiwadia, Elena P. Ivanova, Russell J. Crawford, Takeshi Ohshima, Brant C. Gibsonm, Andrew D. Greentree, Elena Pirogova, and Kate Fox*
Abstract: Additively manufactured selective laser melted titanium (SLM-Ti) opens the possibility of tailored medical implants for patients. Despite orthopedic implant advancements, significant problems remain with regard to suboptimal osseointegration at the interface between the implant and the surrounding tissue. Here, we show that applying a nanodiamond (ND) coating onto SLM-Ti scaffolds provides an improved surface for mammalian cell growth while inhibiting colonization of Staphylococcus aureus bacteria. Owing to the simplicity of our methodology, the approach is suitable for coating SLM-Ti geometries. The ND coating achieved 32 and 29% increases in cell density of human dermal fibroblasts and osteoblasts, respectively, after 3 days of incubation compared with the uncoated SLM-Ti substratum. This increase in cell density complements an 88% reduction in S. aureus detected on the ND-coated SLM-Ti substrata. This study paves a way to create facile antifouling SLM-Ti structures for biomedical implants.
Key Words: nanodiamond, antifouling, 3D printing, biomaterial, implants