Tag Archives: Nicolle Packer

Centre CI at Gordon Glycobiology conference

25 March 2017:

CNBP Chief Investigator Professor Nicki Packer was an invited chair of a session and leader of the Power Hour (gender equality workshop)  at the Gordon Glycobiology conference at Ventura, California 19-24 March, 2017.

As session Chair, Prof Packer led discussion on advances in omics, integrated omics, bioinformatics for glycobiology and the impact of altered glycosylation for human disorders.

The Power Hour was an informal session designed to help address the challenges women face in science and to support the professional growth of women by providing an open forum for discussion and mentoring.

Further conference information is accessible online.

 

Breaking apart sugars

9 March 2017:

CNBP scientists Chris Ashwood and Prof Nicki Packer at Macquarie University have shown alternative ways to break apart sugars, improving their characterisation in their latest publication in the area of mass spectrometry (Enhancing structural characterisation of glucuronidated O-linked glycans using negative mode ion trap higher energy collision-induced dissociation mass spectrometry).

The work was published online in the journal Rapid Communications in Mass Spectrometry on 9th March 2017 and was funded by the Australian Research Council Centre of Excellence for Nanoscale BioPhotonics.

Prof Packer gives plenary lecture at ASMR

Nicki Packer Low Res Edit 012529 April 2016:

The Australian Society of Medical Research (ASMR) has held its 3rd Annual Newcastle Satellite Scientific Meeting, with CNBP Chief Investigator Prof. Nicolle Packer giving the plenary lecture.

With a theme of ‘Supporting Early Career Research’, the meeting attracted health and medical research focused students, research assistants and Early Career Researchers.

Prof Packer spoke about her current research, with a focus on the structure, function, informatics and application of glycans and their conjugates as molecular markers, looking at their role in cancer, therapeutics and microbial infection.

 

Proteomics paper examines knee osteoarthritis

Arun215 March 2016:

CNBP researcher Arun  Everest-Dass and CNBP Chief Investigator Prof Nicolle Packer have both co-authored a newly published paper that reports on a new approach, to better study and understand knee osteoarthritis. The paper was published in the journal ‘Proteomics’.

Title: MALDI mass spectrometry imaging of N-glycans on tibial cartilage and subchondral bone proteins in knee osteoarthritis.

Authors: Matthew T Briggs, Julia S Kuliwaba, Dzenita Muratovic, Arun V Everest-Dass, Nicolle H Packer, David M Findlay and Peter Hoffmann.

Abstract: Magnetic Resonance Imaging (MRI) is a non-invasive technique routinely used to investigate pathological changes in knee osteoarthritis (OA) patients. MRI uniquely reveals zones of the most severe change in the subchondral bone (SCB) in OA, called bone marrow lesions (BMLs). BMLs have diagnostic and prognostic significance in OA, but MRI does not provide a molecular understanding of BMLs. Multiple N-glycan structures have been observed to play a pivotal role in the OA disease process. We applied matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) of N-glycans to formalin-fixed paraffin-embedded (FFPE) SCB tissue sections from patients with knee OA, and liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) was conducted on consecutive sections to structurally characterize and correlate with the N-glycans seen by MALDI-MSI. The application of this novel MALDI-MSI protocol has enabled the first steps to spatially investigate the N-glycome in the SCB of knee OA patients.

The paper can be accessed online.

 

CNBP researchers at National Proteomics Conference

Nicki Packer Low Res Edit 01257 February 2016:

The 21st Annual Lorne Proteomics Symposium, organized by the Australasian Proteomics Society, was held February 4th – 7th 2016 in Lorne, Victoria and was attended by CNBP members of the Macquarie Node, Nicolle Packer, Christopher Ashwood and Abdulrahman Shathili.

The symposium featured the latest developments in proteomics technologies and tools for the interpretation of proteomics outputs, and their application toward answering fundamental questions in biology. Invited speakers included the most cited person in the field of proteomics, Matthias Mann, as well as internationally renowned glycomics expert, Anne Dell. CNBP Chief Investigator Nicolle Packer was also an invited speaker at the event and presented a talk titled “Alterations in Glycosylation in Ovarian Cancer.”

Students Christopher Ashwood and Shathili Abdulrahman both presented posters describing results from the past year, with Christopher Ashwood being awarded a poster prize for his research on characterisation of novel protein-glycosylation using rarely used analytical techniques in the field of glycomics.

Symposium information can be found online.