As we move into week two of voluntary self-isolation, remote workplaces have become the new normal.
Within the CNBP network, we find ourselves drawing on the past six years of managing a community of over 200 researchers who work and collaborate on our research program across the globe.Continue reading →
Few materials shine light like diamond, and researchers are beginning to harness this property to explore the brain in minute detail.
At the Centre for Nanoscale BioPhotonics, Marco Capelli uses these tiny crystals to measure magnetic fields surrounding neurons with the goal of having them side-by-side, leading to fresh insights on cell communication. Continue reading →
Professor Dennis Matthews is one of CNBP’s oldest friends, having been coming to Australia from his home in California each year for nearly seven years as a member of its International Science Committee.
“I’ve actually been coming here since before the CNBP inception. They were just getting their act together for the initial grant when I first visited,” he says.
Professor Matthews was trained as physicist, but for most of his working life he has been involved in the development of medical devices.
His multidisciplinary life is reflected in his position as professor at University of California Davis in both the Department of Neurological Surgery and the College of Engineering. He was at one time also director of UC Davis’ Center for Biophotonics, Science, and Technology.
“I was hired into the neurological department not because I knew anything about neurosurgery but because they wanted their physicians to have more opportunity to do early stage research, even before it could be translated to the clinic,” he says.
He “abandoned physics 30 or 40 years ago”, drawn to things that were more hands-on and, around that time, he met a medical doctor who wanted to develop better instrumentation.
“I told him I didn’t know anything about medicine so he should go away. But he didn’t.”
That started a long history of working with doctors and bioscientists to develop technology that helped in their work.
“Biological scientists are incredibly smart at what they do but they are not so smart at measuring it,” he says.
“I don’t know what their problems are, of course, so they tell me what they are trying to achieve and I tell them ways to get at the solutions to their problems – and we help each other along the way.
“What I like about it, and CNBP works very nicely in this respect, is that you ‘bootstrap’ it. I tell the bioscientists I can do something but I’m not quite sure I know how to do it. So they challenge me to make technology progress at the same time.”
He believes CNBP has some unique strengths – “I wouldn’t travel around 13,000km to come here otherwise”.
He was first introduced to the centre by the inaugural director, Professor Tanya Munro. “I thought she had an extremely good vision of where all this could go and perhaps an even better way of communicating that vision.” Since then, he says, current director Professor Mark Hutchinson has emerged as an incredible thought leader as well.
Professor Matthews says he likes the way the CNBP brings themes together and its “Mission Impossible” approach to throwing multidisciplinary teams of experts at problems.
As a technologist he was also drawn to the IPAS fibre optics group, and the way it was developing fibre sensors to interrogate places that might otherwise be invisible.
Two biological research themes particularly interested him.
“Many of the things here are important to me but there were two that were exceptional and that was Mark’s [Hutchinson] work on neuroscience applied to pain, and particularly his interest in developing a “painometer”.
He was also attracted to the IVF research under Chief Investigator Professor Jeremy Thompson.
“My daughter had two children by IVF and so my interests were already a bit piqued. But I was also interested to see if we could make the whole thing work better.”
Secondly was the possibility of making sure the highest quality embryos were developed and then implanted.
“That whole notion was extremely fascinating and provocative to me,” he says. “I think that we are going to learn how to make embryos healthier in normal conception. And if we can make the healthiest baby possible it can lead to a lifetime of good health.”
Personal experience also lay at the heart of his interest in Professor Hutchinson’s work on pain, which, while important to help people cope at a personal level, he sees as a potential solution to the opiate crisis.
“At the moment we are only delivering pain-masking drugs,” he says. “These powerful drugs don’t do anything except make people not care if they hurt – they still hurt.”
He is helping with the task of looking for biomarkers that might underpin such a measuring device.
“I think it’s possible, but I don’t know yet what the right measurements are,” Professor Matthews says. “And the problem with humans is there is no single recipe, so if we do get a panel of biomarkers that said my pain level was 6 it could be completely wrong for you.
“So we need some way to normalise it so we can say this is a baseline for an individual.”
Professor Matthews is particularly drawn to the CNBP’s focus on envisioning the ultimate translation of the technology.
“So instead of just filling the journals with more manuscripts it is also important in biosciences that you keep in mind that your work will, in the end, actually affect patients.
“The question we should always be asking is ‘how do we get doctors to have the latest technologies to work with?’.”
Working with Dr Jinxian Yu and the recognise theme; Ms Yuan Yeoh has spent 6 weeks as a University of Adelaide summer research student. It has been a pleasure to participate in a summer research project. This has given me an opportunity to learn, as well as to polish my lab skills. I feel happy to utilise the scientific knowledge into real-life applications. A summary of her project is described below.
Synthesis of Azobenzene as a Photo-inducible Molecular Switch
Azobenzene changes configuration (cis & trans) when illuminated with light of particular wavelength. This molecular switch can be incorporated into functional molecules, such as proteins, sensors, electronic devices, etc. Thus, by controlling the configuration of the switch, the electron transfer in functional molecules can be fine tuned.
9 January 2015:
Rupert Parry, a Physics student from University of Sydney and budding movie Director joined Prof Ewa Goldys as a vacation scholar for a 6 week project to review and improve CNBP science communication efforts.
1 November 2014: Summary scholarships for Undergraduates
Mr Dean Southwood and Ms Claudia Cammarata have received Merit Scholar Research Scholarships to work with with CNBP researchers Helen Deng and Prof Ewa Goldys on the project “Liposome nanoparticles for photodynamic therapy of cancer cells”.
Professor Hutchinson was awarded the coveted University of Adelaide “Fig Jam Award” from first year science coordinator Dr Velta Vingelis for a recent lecture to undergraduate students. In the words of Dr Vingelis: I also know for a fact that kids were all amazed and that many will be emailing you, stalking you, in general harrassing you for the opprtunity to work/volunteer in your laboratory. You left an indelible impression on the students and myself.