15 June 2017:
Dr Nima Sayyadi, CNBP researcher, has undertaken guest judging duties at the 2017 Sydney Girls High School Science Conference.
Each year students at Sydney Girls High School complete a research project as part of the NSW Science Curriculum. This project provides Year 9 students with an opportunity to design and perform an investigation into an area of their choice. The annual Science Conference then gives the students a forum where they can present their research to an expert panel.
The panel not only provides students with feedback relating to their investigation, but also determines the projects worthy of further recognition. The determination considers both experimental design and the ability of the student to communicate their ideas.
According to Nima, the standard of work on display was of an incredibly high standard.
“The way that the young students designed their research projects – the hypotheses and preparation and understanding of data limitations was generally quite remarkable.”
Projects being showcased included DNA extraction from fruits with limited facilities through to the analysis of the plastic waste found in water on different beaches in Sydney.
“It was a great experience for me to meet the students, teachers, and other judges from different universities at this event,” concluded Nima.
“Hopefully the passion that these students show for science continues through High School and into tertiary education and beyond.”
22 September 2015:
CNBP’s University of Adelaide research node has undertaken a successful networking event with the SA Dementia Training Study Centre (DTSC).
The event, hosted at the University of Adelaide, saw presentations by Centre Director Mark Hutchinson and Centre researcher Georgios Tsiminis, as well as talks by DTSC attendees as well.
A highlight was Tsiminis’ talk – Dementia and a closer look at Vitamin B12.
28 August, 2015:
Professor Lothar Lilge, from the Princess Margaret Cancer Centre, Toronto, Canada undertook two seminars as part of a visit to the Macquarie University research node of the Centre for Nanoscale BioPhotonics, Friday 28th August, 2015.
Professor Lilge’s first talk was titled: “Making PDT work for GBM and other brain tumours: predicting Photosensitizer accumulation, planning the fluence field and increasing treatment selectivity.” It took place at Macquarie University.
His second talk, titled, “Optical Breast Spectroscopy for Breast Cancer Risk assessment and Identification of women at risk to harbouring early stage breast cancer” took place at the Australian School of Advanced Medicine.
3 July 2015:
As part of the 2015 Macquarie University Photonics Seminar Series, Prof. Ewa Goldys, Deputy Director of the Centre for Nanoscale BioPhotonics gave an informative talk detailing CNBP activity, focus and aspirations for the future.
The seminar series, coordinated by the MQ Photonics Research Centre is the organisation’s main vehicle for gaining feedback on research and for obtaining information on new research.
Abstract details were as follows:
Title: Windows to the Body with Nanobiophotonics
CNBP develops ‘windows to the body’, new methodologies to probe and interrogate nanoscale biochemistry in living organisms. Presented will be current research and new directions in the following areas:
1. Nanoparticle chemical sensors
2. Active nanoparticles
3. Label free bioanalysis in cells and tissues
4. Nanoscale sensing technologies
13 April 2015: CNBP talks to Science Teachers:
Dr Georgios Tsiminis was invited to represent the University of Adelaide at the Science Teachers Association of South Australia Annual Conference and Expo 2015 as an invited Cutting Edge Speaker. Hosted at Brighton Secondary School with an audience of Science teachers from around South Australia.
The talk was titled “Listening to molecules using light: optical detection of chemicals” and co-authors include Dr Joanna Brooks (ARC Centre for Research on Ageing, Health and Wellbeing at the Australian National University), Nigel Spooner (IPAS), Tanya Monro (UniSA/CNBP), Fenghong Chu (Shanghai University of Electric Power).
The talk gave an overview of how light can be used as a tool for detecting chemicals in complex samples and focused on using optical fibres as photonic tools for chemical sensing by Raman spectroscopy. Two examples were given, measuring vitamin B12 in the scope of exploring vitamin B12 deficiency as a modifiable risk factor for dementia and Alzheimer’s; and explosives detection, where Raman spectroscopy was performed using microstructtured suspended core optical fibres to enhance the signal and enable the detection of fundamentally different explosives (TNT and hydrogen peroxide) using the same sensor at quantities of less than a microgram. Both examples highlight the great flexibility of photonic technologies for chemical sensing and establish the cross-disciplinary nature of research undertaken within the CNBP, IPAS and the University of Adelaide.
24 March 2015
Congratulations to Prof Andrew Zannettino, Dr Alex Francois and team for winning an $18,000 grant from the University of Adelaide Interdisciplinary Research Fund for their project ‘Diagnosing multipte myeloma: Development of a point of care device for detecting and monitoring serum free light chain levels in serum’.
The project is aiming of using our Whispering Gallery Mode sensor for the detection of light chain antibodies for medical diagnostics applications.
1 March 2015
Interview with Professor Mark Hutchinson, Professor of Nanoscale BioPhotonics; Radio Adelaide, Adelaide, Orbit, Ewart Shaw; 01 Mar 2015 09:13AM
Hutchinson says a drug addiction has to be maladaptive or bad for the organism to meet the criteria of an addiction. He says the evidence suggests there is the potential to form an addiction to cocaine. He says nicotine, alcohol, and drugs were identified as having different mechanisms of action in the brain, but they all converged onto one key rewards system in the brain. He says they believe they have identified the mechanism by which lots of different drugs of abuse are able to activate a specific pathway, and they all activate it in a similar way. He says they are now working with the US Department of Defence, who are really interested in developing compounds to see if they work in humans. He discusses the social consequences of drug crime. He discusses his work with the Tas alkaloids company [Tasmanian Alkaloids.]
8 January 2015: Adelaide seminar series
CNBP ECRs Michelle Zhang, Daniel Stubing and Malcolm Purdey delivered short presentations about this work on photo switches and chemical sensors as part of the IPAS Seminar series.
17 December 2014: Local Event
Visiting Researcher Professor Sergey Deyev delivered a seminar at Macquarie Node entitled: Multifunctional nanoconstructs for bioimaging and therapy.
Summary: Numerous self-assembly systems have been designed, which allow for control of assembly-disassembly with relatively gentle stimuli. These have applications for the construction of “smart” materials for a number of applications (drug delivery, biosensors, etc.). We address the stability of the barnase−barstar system (BBS) -“glued” assemblies subject to destruction. To this end, we test their behavior under severe protein denaturing conditions such as high temperature and low pH as well as high salt and chaotropic agent (urea and guanidinium hydrochloride) concentrations.
Alternatively, it is desirable to design materials that are hard to disassemble. For example, self-assembled multifunctional theranostic agents are expected to demonstrate significant stability to ensure retention of all functional modules within a single entity to be able to perform all programmed functions e.g., imaging, drug delivery, stimulus-responsiveness. We studied such robust protein-assisted nanoparticle self-assembly systems based on barnase-barstar, streptavidin-biotin, antibody-antigen, and protein A-immunoglobulin interactions. The barnase-barstar pair is particularly advantageous due to its productions by genetic engineering. N- and C-termini of both proteins are not involved in the molecular interface of the proteins within the complex, so they are available for fusions such as those with antibodies, fluorescent proteins, and bacterial toxins, which can be used as additional functional modules of the hybrid protein-particle constructions.
The results on applications of barnase-barstar platform with important types of the nanoparticles, including quantum dots, luminescent nanodiamonds, colloidal gold, magnetic NPs, luminescent upconversion NPs as well as delivery of pseudomonas exotoxin A and radioisotope to the HER2/neu overexpressing human adenocarcinoma cells are presented.
15 December 2014: Three Grants awarded to CNBP researchers
CNBP resarchers at the University of Adelaide were successful in obtaining three IPAS pilot project grants totaling $45,000
Characterisation of aquaporin-1 (AQP1) ion channel activity in migrating cancer cells using a novel photoswitchable fluorescent probe, Andrea Yool, Sabrina Heng, Jinxin (Victor) Pei, $15K
Rapid phenotyping of human stem cells sub-populations using optical spectroscopy, Georgios Tsiminis, Erik Schartner, Simon Koblar, Mark Hutchinson, $10K
UV-guiding silica hollow-core fibre for biological sensing, Philip Light, Sabrina Heng, Chris Perrella, Heike Ebendorff-Heidepriem, $15K