13 November 2017:
Congratulations to Dr Lindsay Parker, CNBP Research Fellow at Macquarie University who has just been granted a Discovery Early Career Researcher Award (DECRA) from the Australian Research Council (ARC).
The award will support the following research activity:
“Intelligently linking nanoscience to neuroscience with glycan biology. This project aims to provide a comprehensive description of the unique cell-surface glycan expression on inflamed neurons, astrocytes, microglia and oligodendrocytes. This project will use glycan profiling data to engineer luminescent nanoparticles with superior neuroimaging qualities for cell type-specific in vivo targeting and drug delivery in the central nervous system. The project outcomes are expected to improve our fundamental understanding of neurobiological cell-surfaces.”
Information on successful DECRA grants can be accessed on the ARC website here.
30 January 2017:
CNBP researchers at Macquarie University – Research Fellow Lindsay Parker (pictured left) and A/Prof Andrei Zvyagin have been successful as Chief Investigators on a $100,000 Macquarie University Research Infrastructure Block Grant.
The grant will support a research assistant (Anna Guller, CNBP PhD candidate) to help build capacity in and use Macquarie University’s bioreactor equipment towards the production and maintenance of live bioartificial tissues for sustainable scientific use.
The CNBP researchers will be collaborating with the University’s Faculty of Medicine to use these artificial biotissues in order to assess nanoparticle detection capabilities/depths in complex tissue structures.
Lead CI on the grant is Professor Qian Yi in the Faculty of Medicine.
15 December 2016:
CNBP researchers were at the forefront of this year’s Biofocus Conference held at Macquarie University, 15 December 2016.
Early career Centre researchers Annemarie Nadort, Lindsay Parker and Nima Sayyadi sat on the conference organising committee, Centre Deputy Director Ewa Goldys (pictured) opened proceedings while CNBP Chief Investigator Prof Andrew Abell (from the University of Adelaide) delivered an extremely well received plenary talk titled, “Defining biomolecular structure and function in solution and on surfaces: new therapeutics and biological probes.”
The annual conference provides a platform for the multidisciplinary community at Macquarie University to present and communicate research, discuss research outcomes and facilitate interdisciplinary collaborations spanning the fields of of biomedical sciences, biomedical engineering, physics, chemistry and medicine.
Feedback from attendees at this year’s event was extremely positive with plenty of formal and informal scientific discussion taking place between sessions.
30 November 2016:
CNBP Research Fellows, Associate Professor Guozhen Liu (pictured), Dr Lindsay Parker and Dr Sabrina Heng have undertaken talks at the School of Biomedical Sciences at the University of Melbourne as part of a Biosensor Symposium, Wednesday 30th November, 2016.
Talks were as follows:
Guozhen Liu – Biophotonic Tools for Cytokine Sensing: From an on-cell surface ELISA to a spatial ELISA device.
Lindsay Parker – Biosensors and glycoproteins: linking nanoscience to neuroscience.
Sabrina Heng – Reversible Sensing with a Flip of the Switch.
The symposium shone a spotlight on multidisciplinary research into developing, applying and using biosensors for biomedical sciences.
28 August 2016:
CNBP researcher Lindsay Parker (pictured left) and CNBP Associate Investigator Jennifer Cornish have coauthored the following paper, examining the relevance of methamphetamine’s to psychosis.
Publication title: GABAergic mRNA Expression is Differentially Expressed Across the Prelimbic and Orbitofrontal Cortices of Rats Sensitized to Methamphetamine: Relevance to Psychosis.
Authors: Travis A. Wearne, Lindsay M. Parker, Jane L. Franklin, Ann K. Goodchild, Jennifer L. Cornish.
Abstract: Psychotic disorders, such as schizophrenia, are characterized by prevalent and persistent executive deficits that are believed to be the result of dysfunctional inhibitory gamma-aminobutyric acid (GABA) processing of the prefrontal cortex (PFC). Methamphetamine (METH) is a commonly used psychostimulant that can induce psychotic and cognitive symptoms that are indistinguishable to schizophrenia, suggesting that METH-induced psychosis may have a similar GABAergic profile of the PFC. As the PFC consists of multiple subregions, the aim of the current study was to investigate changes to GABAergic mRNA expression in the prelimbic (PRL) and orbitofrontal (OFC) cortices of the PFC in rats sensitized to repeated METH administration. Male Sprague Dawley rats underwent daily METH or saline injections for 7 days. Following 14 days of withdrawal, rats were challenged with acute METH administration, RNA was isolated from the PRL and OFC and quantitative PCR was used to compare the relative expression of GABA enzymes, transporters, metabolites and receptor subunits. GAD67, GAD65, GAT1, GAT3, VGAT and GABAT mRNA expression were upregulated in the PRL. Ionotropic GABAA receptor subunits α1, α3, α5 and β2 were specifically upregulated in the OFC. These findings suggest that alterations to GABAergic mRNA expression following sensitization to METH are biologically dissociated between the OFC and PRL, suggesting that GABAergic gene expression is significantly altered following chronic METH exposure in a brain-region and GABA-specific manner. These changes may lead to profound consequences on central inhibitory mechanisms of localized regions of the PFC and may underpin common behavioral phenotypes seen across psychotic disorders.
The paper is available online.
23 May 2016:
Professor Heike Ebendorff-Heidepriem (CNBP Investigator), Dr Lindsay Parker (CNBP Research Fellow) and Dr Andrew Care (CNBP Research Fellow) spoke at the US-Australia Enabling Technologies Technical Exchange Meeting 2016 at UNSW in Sydney on 23-24 May 2016.
Heike’s talk was: “Pushing the Limits in Glass Properties and Structures for Laser, Sensing and Nonlinearity Applications.”
Lindsay’s talk was: “Illuminating mRNA and proteins in new ways with nanoparticles and chemical conjugates.”
Andrew’s talk was: “Developing a platform technology for the self-assembly of functional nanoparticles.”
The purpose of the Technical Exchange is to explore and potentially develop new areas of basic research collaboration between Australian and US participants.
Additional meeting information is available online.
15 February 2016:
Lindsay Parker, CNBP researcher, has presented her work at the SPIE Photonics West Conference, San Francisco, 2016.
The conference is one of the largest Biomedical Optics & Photonics Conferences in the world.
Lindsay’s paper was titled, “Fluorescent nanodiamond and lanthanide labelled in situ hybridization for the identification of RNA transcripts in fixed and CLARITY-cleared central nervous system tissues” and was selected by the chairs of the “Neural Imaging and Sensing” portion of the conference.
Further information on the conference is available online.
12 February 2016:
Fitting in a half day of outreach at McMeen Elementary School in Denver, Colorado, was a highlight for CNBP Research Fellow Lindsay Parker.
Spending time with a class of Year 5 students and their teacher, Lindsay led discussion about what scientists do, how research is conducted and answered a large number of science related queries.
Students were provided with the CNBP educational activity resource sheet and also given an overview of light based research currently being undertaken at the nanoscale.
“Spending time with kids and encouraging their interest in science and technology is a real buzz,” says Lindsay. “These kids were extremely inquisitive which is great.”
11 February 2016:
Ewa Goldys, CNBP Deputy Director and Lindsay Parker, CNBP Research Fellow were invited speakers at the University of Colorado Boulder.
Ewa and Lindsay, hosted by Profs Steven Meier and Linda Watkins from the Department of Psychology & Neuroscience, spoke about various activities and projects currently taking place across the CNBP. Also discussed were potential areas of research collaboration.
10 February 2016:
Lindsay Parker, CNBP Research Fellow, supervised undergraduate student Tereza Lois-Palumbo and Masters student Ashish Shrestha during their 5 week summer scholarship program at Macquarie University.
Tereza and Ashish researched gene changes in multiple cell lines after exposure to LPS inflammation. They learned skills in cell culture, sample staining, microscopy, data analysis and data presentations during their short program.
Ashish will continue to be mentored by Lindsay throughout the year on CNBP related research projects related to ISH gene testing.