Tag Archives: John Horsley

Charge transfer in helical peptides

1 September 2017:

Understanding the electronic properties inherent to peptides is crucial for controlling charge transfer, and precursory to the design and fabrication of bio-inspired next generation electronic components.

However, to achieve this objective one must first be able to predict and control the associated charge transfer mechanisms.

Here CNBP researchers demonstrate for the first time a controllable mechanistic transition in peptides resulting directly from the introduction of a side-bridge.

Journal: RSC Advances.

Publication title: A controllable mechanistic transition of charge transfer in helical peptides: from hopping to superexchange.

Authors: Jingxian Yu (pictured), John R. Horsley and Andrew D. Abell.

For more information, access the paper here.

A step towards bio-inspired quantum interferometers

Jingxian Yu_low_sq29 November 2016:

CNBP researchers (lead author Jingxian Yu pictured), have published a paper exploring the quantum interference effects on electronic transport in peptides. The work has just been reported in the journal ‘Molecular Systems Design & Engineering’ and is accessible online.

Journal: Molecular Systems Design & Engineering.

Title: Exploiting the interplay of quantum interference and backbone rigidity on electronic transport in peptides: A step towards bio-inspired quantum interferometers.

Authors: Jingxian Yu, John R Horsley and Andrew D Abell.

Abstract: Electron transfer in peptides provides an opportunity to mimic nature for applications in bio-inspired molecular electronics. However, quantum interference effects, which become significant at the molecular level, have yet to be addressed in this context. Electrochemical and theoretical studies are reported on a series of cyclic and linear peptides of both β-strand and helical conformation, to address this shortfall and further realize the potential of peptides in molecular electronics. The introduction of a side-bridge into the peptides provides both additional rigidity to the backbone, and an alternative pathway for electron transport. Electronic transport studies reveal an interplay between quantum interference and vibrational fluctuations. We utilize these findings to demonstrate two distinctive peptide-based quantum interferometers, one exploiting the tunable effects of quantum interference (β-strand) and the other regulating the interplay between the two phenomena (310-helix).

CNBP talk at International Conference on Biochemistry

John Horsley Low Res Edit 014116 November 2016:

Dr John Horsley, CNBP researcher from the University of Adelaide, presented his recent work at the International Conference on Biochemistry held in Kuala Lumpur, Malaysia, October 16th, 2016.

His poster presentation and talk was entitled ‘Controlling the Conformation of a Modified Gramicidin S Cyclic Peptidomimetic with an Azobenzene Photoswitch’.

CNBP researchers visit Wuhan

Wuhan12 October 2015:

CNBP researchers from the University of Adelaide, Dr Jingxian Yu and Dr John Horsley, were invited by several academic facilities in Wuhan, China, to disseminate their recent research.

Lectures were given to the School of Chemistry and Chemical Engineering at Huazhong University of Science and Technology (HUST), China University of Geosciences (CUG), and Central China Normal University (CCNU).

A number of ‘flyers’ were circulated defining the role of the CNBP, in the hope of inspiring bright, enthusiastic students and academics alike to consider a move to Australia.

Whilst in Wuhan, they also had the opportunity and pleasure of visiting CNBP partner, Wuhan National Laboratory for Optoelectronics (HUST), and the Key Laboratory of Biomedical Polymers of the Ministry of Education, at Wuhan University.

Networking provided a number of possible future collaborations, including electron transport in single molecules, with Professors Shan Jin and Shenghua Liu (CCNU), and peptide-based nanocarriers for drug delivery, with Prof Xianzheng Zhang (Wuhan University).

 

PhD commendation

John Horsley Low Res Edit 01417 July 2015:

Congratulations to CNBP researcher John Horsley, who has just been awarded a Dean’s Commendation for Doctoral Thesis Excellence from the University of Adelaide.  A Commendation is awarded when all examiners consider the thesis to be ‘outstanding’.

John’s thesis, titled “The Effects of Macrocyclic Constraints on Electron Transfer in Peptides”, examined the importance of secondary structure characteristics to proteins/peptides, and its relevance to electronic transport.

Currently, John is working on synthesizing a light-driven peptide-based sensor to detect changes in ligand/receptor interactions for the CNBP.

 

Adelaide node welcomes new research fellows

NeuroFebruary 2015: Welcome:

CNBP Adelaide Node are pleased to welcome new CNBP Research Fellow commencing in January/February 2015.

  • Jenny Butler who is joined the Recognise theme on January 28th
  • Peipei Jia who joined the Measure and Illuminate theme on January 31st
  • Xiaozhou (Michelle) Zhang who joined the Recognise theme on February 9
  • John Horsley who joined the Recognise theme on February 9

John Horsely wins IPAS Best PhD Student Paper

John Horsley Low Res Edit 014130 January 2015

Congratulations to John Horsley who recently joined CNBP as  postdoctoral researcher for winning the “IPAS Best PhD Student Paper Awards” for his 2014 CNBP publication “Unraveling the Interplay of Backbone Rigidity and Electron Rich Side-Chains on Electron Transfer in Peptides: The Realization of Tunable Molecular Wires” Journal of the American Chemical Society, 2014, 136, 12479.
The research reported in this paper provides a crucial step in the design and fabrication of molecular-based electronic devices. The paper was highlighted by F1000Prime, a post-publication peer review comprising of more than 5,000 of the world’s leading scientists and recommended as being of special significance in its field.
*The above paper was also highlighted in the Feb. 2015 edition of the magazine ‘Chemistry in Australia’ (p.12).
**It was also listed in the top ten articles since 2014 in BioMedLib.

Publication – Journal of the American Chemical Society

ThemesSeptember 2014 – Journal of the American Chemical Society

Unraveling the interplay of backbone rigidity and electron rich side-chains on electron transfer in peptides: the realization of tunable molecular wires.

Horsley JR, Yu J, Moore KE, Shapter JG, Abell AD. J Am Chem Soc. 2014 Sep 3; 136(35):12479-88

For the full article please click here