1 September 2017:
Understanding the electronic properties inherent to peptides is crucial for controlling charge transfer, and precursory to the design and fabrication of bio-inspired next generation electronic components.
However, to achieve this objective one must first be able to predict and control the associated charge transfer mechanisms.
Here CNBP researchers demonstrate for the first time a controllable mechanistic transition in peptides resulting directly from the introduction of a side-bridge.
Journal: RSC Advances.
Publication title: A controllable mechanistic transition of charge transfer in helical peptides: from hopping to superexchange.
Authors: Jingxian Yu (pictured), John R. Horsley and Andrew D. Abell.
For more information, access the paper here.
28 July 2017:
CNBP Research Fellow Dr Jingxian Yu has given a talk at the RACI Centenary Congress, at the Melbourne Convention and Exhibition Centre, 23 – 28 July 2017.
The title of his talk was ‘Gating Electron Transfer in Peptides Towards Molecular Switches’.
5 July 2017:
CNBP Researcher, Dr Yu, from the University of Adelaide, presented recent findings on “Gating Electron Transfer in Peptides Towards Molecular Switches” at the International Conference on Materials for Advanced Technologies, commonly known as ICMAT 2017, held in Singapore, 18-24 June. It attracted more than 2,500 delegates from all over the world.
Following the ICMAT 2017, Dr Yu made a trip to Chongqing University, one of 985 project Universities in China. An invited lecture was given to the School of Chemistry and Chemical Engineering and he met with Professors Xiaohua Chen, Yi Xu, and Lingjie Li.
While in Chongqing, he also made a visit to the microfabrication facilities, including the MEMS, Wafer Lithography and clean room at the Centre of MicroFabrication and MicroSystems, Chongqing University. Networking provided a number of possible future collaborations.
Below – Dr Yu presenting CNBP science at Chongqing University.
18 May 2017:
An ‘Institute for Photonics and Advanced Sensing’ (IPAS) pilot grant worth $6,000 has been awarded to CNBP researchers Dr Jingxian Yu (project lead – pictured left) and Dr Peipei Jia.
The grant will allow investigation into “double remote electrochemical addressing and optical readout of electrochemiluminescence at the nanopatterned tip of an optical fiber for the detection of biological species.”
The project has great potential to provide a versatile sensing platform for chemical sensing and medical diagnostics.
The proposed work will also bring chemists and physicists together to work in this trans-disciplinary area, with the possibility of promoting further collaborations between biological and medical scientists within IPAS and the CNBP.
2 December 2016:
CNBP Research Fellow Dr Jingxian Yu presented a talk at the RACI SA Physical Chemistry Symposium, held at the University of South Australia on December 2, 2016.
His talk was entitled “Peptides as electronic materials: Insights from experiment and theory”.
29 November 2016:
CNBP researchers (lead author Jingxian Yu pictured), have published a paper exploring the quantum interference effects on electronic transport in peptides. The work has just been reported in the journal ‘Molecular Systems Design & Engineering’ and is accessible online.
Journal: Molecular Systems Design & Engineering.
Title: Exploiting the interplay of quantum interference and backbone rigidity on electronic transport in peptides: A step towards bio-inspired quantum interferometers.
Authors: Jingxian Yu, John R Horsley and Andrew D Abell.
Abstract: Electron transfer in peptides provides an opportunity to mimic nature for applications in bio-inspired molecular electronics. However, quantum interference effects, which become significant at the molecular level, have yet to be addressed in this context. Electrochemical and theoretical studies are reported on a series of cyclic and linear peptides of both β-strand and helical conformation, to address this shortfall and further realize the potential of peptides in molecular electronics. The introduction of a side-bridge into the peptides provides both additional rigidity to the backbone, and an alternative pathway for electron transport. Electronic transport studies reveal an interplay between quantum interference and vibrational fluctuations. We utilize these findings to demonstrate two distinctive peptide-based quantum interferometers, one exploiting the tunable effects of quantum interference (β-strand) and the other regulating the interplay between the two phenomena (310-helix).
26 October 2016:
Dr Jingxian Yu, CNBP researcher has attended the Workshop on Precision Sensing for Defence, held at the Australian National University on October 23-25th 2016. The workshop was by invitation only with the aim of presenting and discussing Australia’s strengths in precision sensing technology, and to plan for collaborative arrangements to advance Australian precision sensing thorough the newly launched Next Generation Fund.
5 June 2016:
CNBP Researcher, Dr Jingxian Yu, from the University of Adelaide, presented recent research on “Peptide-Based Quantum Interferometers and Their Sensing Applications” at the prestigious Gordon Research Conference on Electronic Processes in Organic Materials in Lucca, Italy, from 5-10 June 2016.
At the conference, chemists, physicists and materials scientists from all over the world addressed the key challenges in the field related to photophysical and charge transport processes in organic materials and discussed how molecular architectures could provide new and enhanced functionalities.
1 June 2016:
CNBP researcher from the University of Adelaide, Dr Jingxian Yu, was invited by several academic facilities in both China and Israel to disseminate his recent research. Lectures were given to the Department of Chemical Engineering at Xiamen University, China, Professor David Cahen’s group at the Weizmann Institute of Science, and the Department of Materials Engineering at Ben Gurion University of the Negev, Israel.
Whilst in China, Jingxian initialised the collaboration on electron transport in single molecules with Professor Wenjing Hong. He also met Professors Deying Wu, Shoufa Han, Dongping Zhan, and Jiawei Yan.
In Israel, he met Professors David Cahen, Mudi Sheves, Ron Naaman, and Drs Ayelet Vilan, Cunlan Guo, Sabyasachi Mukhopadhyay at the Weizmann Institute of Science, Professors Nurit Ashkenasy, Gonen Ashkenasy, Raz Jelinek, Hanna Rapaport and Drs Ronit Bitton, Mark Schvartzman, Hadar Ben Yoav, and Yifat Miller at the Ben Gurion University of the Negev. Networking provided a number of possible future collaborations.
June 1, 2016: School of Chemical Engineering, Xiamen University, China
June 13, 2016: Professor David Cahen Group, Weizmann Institute of Science, Israel.
June 14, 2016: Department of Materials Engineering at Ben Gurion University of the Negev, Israel
10 May 2016:
CNBP scientists have authored a new paper in the journal Electrochimica Acta. Details follow below.
Publication title: Turning electron transfer ‘on-off’ in peptides through side-bridge gating.
Authors: Jingxian Yu, , John R. Horsley and Andrew D. Abell.
Abstract: Electrochemical studies are reported on a series of peptides to determine the influence of different side-chains and backbone rigidity on electron transfer, to progress the field of molecular electronics. Specifically, these peptides share either a common helical or β-strand conformation to cover a range of secondary structures, to fully investigate the influence of backbone rigidity. Two types of side-chain tethers, either triazole-containing or alkene-containing, are also compared to investigate these effects on electron transfer. Our results showed that the observed formal potentials (Eo) and electron transfer rate constants (ket) fall into two distinct groups. The peptides constrained via a side-chain tether exhibited high formal potentials and low electron transfer rate constants, whereas the linear peptides displayed low formal potentials and high electron transfer rate constants. This was found to occur irrespective of the backbone conformation, or the nature of the side-chain constraint. The vast formal potential shifts (as much as 482 mV) and the large disparity in the electron transfer rate constants (as much as 97%) between the constrained and linear peptides, provides two distinct states (i.e. on/off) with a sizeable differential, which is ideal for the design of molecular switches.
The research paper is available online.