Exploring the nooks and crannies of the body’s organs seems fodder for a sci-fi movie. Yet, an international team of researchers and engineers has made this a reality — and it’s set to change the way we see human diseases. Continue reading
Dr Asma Khalid enjoys wearing silk dresses, and appreciates diamonds for their beauty —but she never expected both silk and diamonds to end up being the cornerstone of her work as a physicist. Yet they have opened up a whole new way to see deep in the body, sense infections on the skin and even deliver drugs in controlled amounts. Continue reading
Coronary artery disease kills around 7 million people each year, making it the leading cause of death worldwide.
The culprit behind this life-threatening condition is build-up of high-risk plaque in the arteries which cause blood clots that block blood flow to the heart. But diagnosing this plaque before it becomes life-threatening is still a major challenge for medical practitioners. Continue reading
A group of high achieving STEM students from Adelaide High School visited the University of Adelaide, 21 November 2018.
As a part of this visit, CNBP researcher Dr Jiawen Li took the time to show them around the Bio Sensing Laboratory while also explaining the research that took place there.
A new paper published in Scientific Reports demonstrates the feasibility of 3D printing of optical coherence tomography (OCT) fibre-optic probes. Lead author on the publication is CNBP’s Dr Jiawen Li (pictured).
Journal: Scientific Reports.
Authors: Jiawen Li, Peter Fejes, Dirk Lorenser, Bryden C. Quirk, Peter B. Noble, Rodney W. Kirk, Antony Orth, Fiona M. Wood, Brant C. Gibson, David D. Sampson & Robert A. McLaughlin.
Abstract: Miniaturised optical coherence tomography (OCT) fibre-optic probes have enabled high-resolution cross-sectional imaging deep within the body. However, existing OCT fibre-optic probe fabrication methods cannot generate miniaturised freeform optics, which limits our ability to fabricate probes with both complex optical function and dimensions comparable to the optical fibre diameter. Recently, major advances in two-photon direct laser writing have enabled 3D printing of arbitrary three-dimensional micro/nanostructures with a surface roughness acceptable for optical applications. Here, we demonstrate the feasibility of 3D printing of OCT probes. We evaluate the capability of this method based on a series of characterisation experiments. We report fabrication of a micro-optic containing an off-axis paraboloidal total internal reflecting surface, its integration as part of a common-path OCT probe, and demonstrate proof-of-principle imaging of biological samples.
A class of Year 11 Physics students from Loreto College, Marryatville, South Australia were visited by CNBP researcher Dr Jiawen Li, September 20th, 2018.
During the outreach visit Dr Li spoke on the medical uses of fibre optics technology and answered questions from the class, helping shed light on the life of a scientist and explaining the wide-range of career options open to STEM students.
“I really enjoyed visiting the school and found the session an extremely rewarding experience,” said Dr Li.
“Student questions following the presentation were well thought through and hopefully I helped in some small way to encourage the girls to continue their study of physics and other STEM related subjects.”
“Higher education potentially opens up a wide range of exciting career opportunities right across the science, engineering and medical disciplines,” said Dr Li. “And it would be great to see these enthusiastic students get to University.”
Feedback from the school post-event noted that the students had found Dr Li to be a fantastic role model and that her presentation session had been particularly inspiring.
Below: Students from Loreto College at the outreach session.
CNBP researchers have published a new trans-disciplinary review that reports on the Centre’s development of advanced optical fibre probes for use in biomedical sensing and imaging. The paper examines CNBP innovation through convergence of multiple science disciplines to generate opportunities for the fibre probes to address key challenges in real-time in vivo diagnostics. The lead author on the paper is Dr Jiawen Li (pictured).
Journal: APL Photonics.
Authors: Jiawen Li, Heike Ebendorff-Heidepriem, Brant C. Gibson, Andrew D. Greentree, Mark R. Hutchinson, Peipei Jia, Roman Kostecki, Guozhen Liu, Antony Orth, Martin Ploschner, Erik P. Schartner, Stephen C. Warren-Smith, Kaixin Zhang, Georgios Tsiminis, and Ewa M. Goldys.
Abstract: The probing of physiological processes in living organisms is a grand challenge that requires bespoke analytical tools. Optical fiber probes offer a minimally invasive approach to report physiological signals from specific locations inside the body. This perspective article discusses a wide range of such fiber probes developed at the Australian Research Council Centre of Excellence for Nanoscale BioPhotonics. Our fiber platforms use a range of sensing modalities, including embedded nanodiamonds for magnetometry, interferometric fiber cavities for refractive index sensing, and tailored metal coatings for surface plasmon resonance sensing. Other fiber probes exploit molecularly sensitive Raman scattering or fluorescence where optical fibers have been combined with chemical and immunosensors. Fiber imaging probes based on interferometry and computational imaging are also discussed as emerging in vivo diagnostic devices. We provide examples to illustrate how the convergence of multiple scientific disciplines generates opportunities for the fiber probes to address key challenges in real-time in vivo diagnostics. These future fiber probes will enable the asking and answering of scientific questions that were never possible before.
CNBP’s Dr Jiawen Li has given a science talk at the College of Optical Science and Engineering, Zhejiang University, China, 7th June, 2018. The talk’s title was ‘Miniaturized multimodal fibre-optic probes for biomedical applications’.
While at the college, Dr Li also visited laboratories specialising in super resolution microscopy, holography and optical coherence tomograpy (OCT). She also shared with undergraduate and master students, her experiences of studying in both the United States and Australia, and provided her perspective on potential career paths for post-doctorate researchers.
A world-first tiny fibre-optic probe that can simultaneously measure temperature and sense deep inside the body has been reported by CNBP/IPAS researchers. According to lead author of the research, Dr Jiawen Li at the University of Adelaide, the probe may help researchers find better treatments to prevent drug-induced overheating of the brain, and potentially refine thermal treatment for cancers. Read the media release or click on the publication title below!
Journal: Optics Letters.
Authors: Jiawen Li, Erik Schartner, Stefan Musolino, Bryden C. Quirk, Rodney W. Kirk, Heike Ebendorff-Heidepriem, and Robert A. McLaughlin.
Abstract: The ability to visualize structure while simultaneously measuring chemical or physical properties of a biological tissue has the potential to improve our understanding of complex biological processes. We report the first miniaturized single-fiber-based imaging+sensing probe capable of simultaneous optical coherence tomography (OCT) imaging and temperature sensing. An OCT lens is fabricated at the distal end of a double-clad fiber, including a thin layer of rare-earth-doped tellurite glass to enable temperature measurements. The high refractive index of the tellurite glass enables a common-path interferometer configuration for OCT, allowing easy exchange of probes for biomedical applications. The simultaneous imaging+sensing capability is demonstrated on rat brains.
Congratulations to the following CNBP students and researchers who were successful at the annual ‘Institute for Photonics and Advanced Sensing (IPAS) Awards’.
- Jiawen Li (Joint IPAS Best ECR Paper)
- Team: Patrick Capon, Malcolm Purdey, Benjamin Pullen and Andrew Abell (IPAS Best Transdisciplinary Paper)
- Kathryn Palasis (Tanya Monro Best Student Oral Presentation)