4 October 2018:
A new paper published in Scientific Reports demonstrates the feasibility of 3D printing of optical coherence tomography (OCT) fibre-optic probes. Lead author on the publication is CNBP’s Dr Jiawen Li (pictured).
Journal: Scientific Reports.
Publication title: Two-photon polymerisation 3D printed freeform micro-optics for optical coherence tomography fibre probes.
Authors: Jiawen Li, Peter Fejes, Dirk Lorenser, Bryden C. Quirk, Peter B. Noble, Rodney W. Kirk, Antony Orth, Fiona M. Wood, Brant C. Gibson, David D. Sampson & Robert A. McLaughlin.
Abstract: Miniaturised optical coherence tomography (OCT) fibre-optic probes have enabled high-resolution cross-sectional imaging deep within the body. However, existing OCT fibre-optic probe fabrication methods cannot generate miniaturised freeform optics, which limits our ability to fabricate probes with both complex optical function and dimensions comparable to the optical fibre diameter. Recently, major advances in two-photon direct laser writing have enabled 3D printing of arbitrary three-dimensional micro/nanostructures with a surface roughness acceptable for optical applications. Here, we demonstrate the feasibility of 3D printing of OCT probes. We evaluate the capability of this method based on a series of characterisation experiments. We report fabrication of a micro-optic containing an off-axis paraboloidal total internal reflecting surface, its integration as part of a common-path OCT probe, and demonstrate proof-of-principle imaging of biological samples.
20 September 2018:
A class of Year 11 Physics students from Loreto College, Marryatville, South Australia were visited by CNBP researcher Dr Jiawen Li, September 20th, 2018.
During the outreach visit Dr Li spoke on the medical uses of fibre optics technology and answered questions from the class, helping shed light on the life of a scientist and explaining the wide-range of career options open to STEM students.
“I really enjoyed visiting the school and found the session an extremely rewarding experience,” said Dr Li.
“Student questions following the presentation were well thought through and hopefully I helped in some small way to encourage the girls to continue their study of physics and other STEM related subjects.”
“Higher education potentially opens up a wide range of exciting career opportunities right across the science, engineering and medical disciplines,” said Dr Li. “And it would be great to see these enthusiastic students get to University.”
Feedback from the school post-event noted that the students had found Dr Li to be a fantastic role model and that her presentation session had been particularly inspiring.
Below: Students from Loreto College at the outreach session.
10 September 2018:
CNBP researchers have published a new trans-disciplinary review that reports on the Centre’s development of advanced optical fibre probes for use in biomedical sensing and imaging. The paper examines CNBP innovation through convergence of multiple science disciplines to generate opportunities for the fibre probes to address key challenges in real-time in vivo diagnostics. The lead author on the paper is Dr Jiawen Li (pictured).
Journal: APL Photonics.
Publication title: Perspective: Biomedical sensing and imaging with optical fibers—Innovation through convergence of science disciplines.
Authors: Jiawen Li, Heike Ebendorff-Heidepriem, Brant C. Gibson, Andrew D. Greentree, Mark R. Hutchinson, Peipei Jia, Roman Kostecki, Guozhen Liu, Antony Orth, Martin Ploschner, Erik P. Schartner, Stephen C. Warren-Smith, Kaixin Zhang, Georgios Tsiminis, and Ewa M. Goldys.
Abstract: The probing of physiological processes in living organisms is a grand challenge that requires bespoke analytical tools. Optical fiber probes offer a minimally invasive approach to report physiological signals from specific locations inside the body. This perspective article discusses a wide range of such fiber probes developed at the Australian Research Council Centre of Excellence for Nanoscale BioPhotonics. Our fiber platforms use a range of sensing modalities, including embedded nanodiamonds for magnetometry, interferometric fiber cavities for refractive index sensing, and tailored metal coatings for surface plasmon resonance sensing. Other fiber probes exploit molecularly sensitive Raman scattering or fluorescence where optical fibers have been combined with chemical and immunosensors. Fiber imaging probes based on interferometry and computational imaging are also discussed as emerging in vivo diagnostic devices. We provide examples to illustrate how the convergence of multiple scientific disciplines generates opportunities for the fiber probes to address key challenges in real-time in vivo diagnostics. These future fiber probes will enable the asking and answering of scientific questions that were never possible before.
7 June 2018:
CNBP’s Dr Jiawen Li has given a science talk at the College of Optical Science and Engineering, Zhejiang University, China, 7th June, 2018. The talk’s title was ‘Miniaturized multimodal fibre-optic probes for biomedical applications’.
While at the college, Dr Li also visited laboratories specialising in super resolution microscopy, holography and optical coherence tomograpy (OCT). She also shared with undergraduate and master students, her experiences of studying in both the United States and Australia, and provided her perspective on potential career paths for post-doctorate researchers.
6 April 2018:
A world-first tiny fibre-optic probe that can simultaneously measure temperature and sense deep inside the body has been reported by CNBP/IPAS researchers. According to lead author of the research, Dr Jiawen Li at the University of Adelaide, the probe may help researchers find better treatments to prevent drug-induced overheating of the brain, and potentially refine thermal treatment for cancers. Read the media release or click on the publication title below!
Journal: Optics Letters.
Publication title: Miniaturized single-fiber-based needle probe for combined imaging and sensing in deep tissue.
Authors: Jiawen Li, Erik Schartner, Stefan Musolino, Bryden C. Quirk, Rodney W. Kirk, Heike Ebendorff-Heidepriem, and Robert A. McLaughlin.
Abstract: The ability to visualize structure while simultaneously measuring chemical or physical properties of a biological tissue has the potential to improve our understanding of complex biological processes. We report the first miniaturized single-fiber-based imaging+sensing probe capable of simultaneous optical coherence tomography (OCT) imaging and temperature sensing. An OCT lens is fabricated at the distal end of a double-clad fiber, including a thin layer of rare-earth-doped tellurite glass to enable temperature measurements. The high refractive index of the tellurite glass enables a common-path interferometer configuration for OCT, allowing easy exchange of probes for biomedical applications. The simultaneous imaging+sensing capability is demonstrated on rat brains.
Below – Dr Jiawen Li.
28 February, 2018:
Congratulations to the following CNBP students and researchers who were successful at the annual ‘Institute for Photonics and Advanced Sensing (IPAS) Awards’.
- Jiawen Li (Joint IPAS Best ECR Paper)
- Team: Patrick Capon, Malcolm Purdey, Benjamin Pullen and Andrew Abell (IPAS Best Transdisciplinary Paper)
- Kathryn Palasis (Tanya Monro Best Student Oral Presentation)
8 November 2017:
The world’s smallest fibre-optic probe that can simultaneously see and sense deeply inside the body (Dr Jiawen Li) and an anti-cancer drug that can be switched ‘on’ and ‘off’ inside the body to help reduce chemotherapy side effects (PhD student Kathryn Palasis). These were the research narratives developed by the two CNBP scientists who attended the ‘Fresh Science’ outreach training program on the 7th-8th November in Adelaide, South Australia.
“I had a great time participating in Fresh Science,” said Kathryn Palasis.
“We had a full day of media training which included practise interviews with journalists from TV, radio and print, who taught us how to best explain our science to the general public. We then had the opportunity to present our work to some very eager and inquisitive school students, and later had to summarise our research to a crowd at the pub in the time it took for a sparkler to burn out! It was a great learning experience and a lot of fun – plus I got to meet some really cool local researchers who are all doing exciting work.”
Dr Jiawen Li also enjoyed the experience. “What I got from the program was the ability to promote my science to the media, knowledge on how to be noticed by journalists and the experience of being interviewed, as well as broader presentation skills aimed at communicating complicated science concepts to a general audience. The two days were extremely rewarding!”
Fresh Science (run by Science in Public) is a national competition helping early-career researchers find, and then share, their stories of discovery. The program takes up-and-coming researchers with no media experience and turns them into spokespeople for science, with a day of media training and a public outreach event in their home state.
Below – Fresh Science participants. Kathryn Palasis fourth from left. Dr Jiawen Li fourth from right. Photo credit: Fresh Science/Science in Public.
11 October 2017:
A new publication from CNBP researchers explores the integration of an optical coherence tomography (OCT) probe into a flexible needle for lung tissue aspiration. The paper (lead author Jiawen Li pictured), was published in the Journal of Biomedical Optics and is accessible online.
Journal: Journal of Biomedical Optics.
Publication title: Flexible needle with integrated optical coherence tomography probe for imaging during transbronchial tissue aspiration.
Authors: Jiawen Li; Bryden C. Quirk; Peter B. Noble; Rodney W. Kirk; David D. Sampson; Robert A. McLaughlin.
Abstract: Transbronchial needle aspiration (TBNA) of small lesions or lymph nodes in the lung may result in nondiagnostic tissue samples. We demonstrate the integration of an optical coherence tomography (OCT) probe into a 19-gauge flexible needle for lung tissue aspiration. This probe allows simultaneous visualization and aspiration of the tissue. By eliminating the need for insertion and withdrawal of a separate imaging probe, this integrated design minimizes the risk of dislodging the needle from the lesion prior to aspiration and may facilitate more accurate placement of the needle. Results from in situ imaging in a sheep lung show clear distinction between solid tissue and two typical constituents of nondiagnostic samples (adipose and lung parenchyma). Clinical translation of this OCT-guided aspiration needle holds promise for improving the diagnostic yield of TBNA.
13 June 2017:
Congratulations to Dr Jiawen Li, CNBP researcher at the University of Adelaide, who recently won a Women’s Research Excellence award.
Jiawen’s work is focused on the development of highly novel dual-modality ultrasound/optical coherence tomography imaging probes for diagnosis of disease and for use in surgical applications.
She will be using the award to assist with travel to RMIT and Hong Kong Polytechnic University, where she hopes to build on existing collaborations.
12 February 2017:
Dr Jiawen Li, CNBP researcher, has given a number of invited talks, on her ongoing work with optical coherence tomography (OCT) and fiber-optic needle probes.
Her talks were focused on addressing the penetration-depth limitation of optical imaging through the development of miniaturised fibre-optic probes that may be inserted deep into the body.
Representative technologies and their ex vivo and in vivo applications were presented by Jiawen at both the Wellman Center for Photomedicine at Harvard Medical School (HMS) as well as at Polytechnic Montreal.
She saw great value in both visits, noting:
“I first visited the Wellman Center for Photomedicine (Feb 6th-7th), where I gave a talk, and met with Dr. Melissa Suter and Prof. Brett Bouma and their postdoctoral teams. Researchers there also gave me a tour of their laboratories. They showed me prototypes that they had made for clinical applications and shared with me their insights as to how to achieve successful and enhance efficient collaborations with clinicians. Attendees at my talk were very interested in our work on smart needles for safer and more effective brain surgery and on fabricating miniaturized lenses by the 3D printer at CNBP RMIT node, a project that is supported by a CNBP travel grant. Potential future collaborations were also explored.”
“At Polytechnic Montreal (Feb 8th-10th), I met with A/Prof. Caroline Boudoux, a collaborator on our fluorescence-OCT project, as well as postdoctoral researchers of A/Prof. Frederic Leblond. I visited both A/Prof. Leblond’s laboratory and A/Prof. Boudoux’s spin-out company Castor Optics. A technical meeting was held, where we discussed solutions to overcoming technical challenges in our current design. This visit strengthened our existing collaboration.”
A busy time for Jiawen, she also managed to fit in an oral presentation at the SPIE Photonics West 2017 Conference on January 28th , 2017. Her presentation was titled, “Flexible OCT needle probes for image-guided endoscopic tissue aspiration.”