6 April 2018:
A world-first tiny fibre-optic probe that can simultaneously measure temperature and sense deep inside the body has been reported by CNBP/IPAS researchers. According to lead author of the research, Dr Jiawen Li at the University of Adelaide, the probe may help researchers find better treatments to prevent drug-induced overheating of the brain, and potentially refine thermal treatment for cancers. Read the media release or click on the publication title below!
Journal: Optics Letters.
Publication title: Miniaturized single-fiber-based needle probe for combined imaging and sensing in deep tissue.
Authors: Jiawen Li, Erik Schartner, Stefan Musolino, Bryden C. Quirk, Rodney W. Kirk, Heike Ebendorff-Heidepriem, and Robert A. McLaughlin.
Abstract: The ability to visualize structure while simultaneously measuring chemical or physical properties of a biological tissue has the potential to improve our understanding of complex biological processes. We report the first miniaturized single-fiber-based imaging+sensing probe capable of simultaneous optical coherence tomography (OCT) imaging and temperature sensing. An OCT lens is fabricated at the distal end of a double-clad fiber, including a thin layer of rare-earth-doped tellurite glass to enable temperature measurements. The high refractive index of the tellurite glass enables a common-path interferometer configuration for OCT, allowing easy exchange of probes for biomedical applications. The simultaneous imaging+sensing capability is demonstrated on rat brains.
Below – Dr Jiawen Li.
28 February, 2018:
Congratulations to the following CNBP students and researchers who were successful at the annual ‘Institute for Photonics and Advanced Sensing (IPAS) Awards’.
- Jiawen Li (Joint IPAS Best ECR Paper)
- Team: Patrick Capon, Malcolm Purdey, Benjamin Pullen and Andrew Abell (IPAS Best Transdisciplinary Paper)
- Kathryn Palasis (Tanya Monro Best Student Oral Presentation)
8 November 2017:
The world’s smallest fibre-optic probe that can simultaneously see and sense deeply inside the body (Dr Jiawen Li) and an anti-cancer drug that can be switched ‘on’ and ‘off’ inside the body to help reduce chemotherapy side effects (PhD student Kathryn Palasis). These were the research narratives developed by the two CNBP scientists who attended the ‘Fresh Science’ outreach training program on the 7th-8th November in Adelaide, South Australia.
“I had a great time participating in Fresh Science,” said Kathryn Palasis.
“We had a full day of media training which included practise interviews with journalists from TV, radio and print, who taught us how to best explain our science to the general public. We then had the opportunity to present our work to some very eager and inquisitive school students, and later had to summarise our research to a crowd at the pub in the time it took for a sparkler to burn out! It was a great learning experience and a lot of fun – plus I got to meet some really cool local researchers who are all doing exciting work.”
Dr Jiawen Li also enjoyed the experience. “What I got from the program was the ability to promote my science to the media, knowledge on how to be noticed by journalists and the experience of being interviewed, as well as broader presentation skills aimed at communicating complicated science concepts to a general audience. The two days were extremely rewarding!”
Fresh Science (run by Science in Public) is a national competition helping early-career researchers find, and then share, their stories of discovery. The program takes up-and-coming researchers with no media experience and turns them into spokespeople for science, with a day of media training and a public outreach event in their home state.
Below – Fresh Science participants. Kathryn Palasis fourth from left. Dr Jiawen Li fourth from right. Photo credit: Fresh Science/Science in Public.
11 October 2017:
A new publication from CNBP researchers explores the integration of an optical coherence tomography (OCT) probe into a flexible needle for lung tissue aspiration. The paper (lead author Jiawen Li pictured), was published in the Journal of Biomedical Optics and is accessible online.
Journal: Journal of Biomedical Optics.
Publication title: Flexible needle with integrated optical coherence tomography probe for imaging during transbronchial tissue aspiration.
Authors: Jiawen Li; Bryden C. Quirk; Peter B. Noble; Rodney W. Kirk; David D. Sampson; Robert A. McLaughlin.
Abstract: Transbronchial needle aspiration (TBNA) of small lesions or lymph nodes in the lung may result in nondiagnostic tissue samples. We demonstrate the integration of an optical coherence tomography (OCT) probe into a 19-gauge flexible needle for lung tissue aspiration. This probe allows simultaneous visualization and aspiration of the tissue. By eliminating the need for insertion and withdrawal of a separate imaging probe, this integrated design minimizes the risk of dislodging the needle from the lesion prior to aspiration and may facilitate more accurate placement of the needle. Results from in situ imaging in a sheep lung show clear distinction between solid tissue and two typical constituents of nondiagnostic samples (adipose and lung parenchyma). Clinical translation of this OCT-guided aspiration needle holds promise for improving the diagnostic yield of TBNA.
13 June 2017:
Congratulations to Dr Jiawen Li, CNBP researcher at the University of Adelaide, who recently won a Women’s Research Excellence award.
Jiawen’s work is focused on the development of highly novel dual-modality ultrasound/optical coherence tomography imaging probes for diagnosis of disease and for use in surgical applications.
She will be using the award to assist with travel to RMIT and Hong Kong Polytechnic University, where she hopes to build on existing collaborations.
12 February 2017:
Dr Jiawen Li, CNBP researcher, has given a number of invited talks, on her ongoing work with optical coherence tomography (OCT) and fiber-optic needle probes.
Her talks were focused on addressing the penetration-depth limitation of optical imaging through the development of miniaturised fibre-optic probes that may be inserted deep into the body.
Representative technologies and their ex vivo and in vivo applications were presented by Jiawen at both the Wellman Center for Photomedicine at Harvard Medical School (HMS) as well as at Polytechnic Montreal.
She saw great value in both visits, noting:
“I first visited the Wellman Center for Photomedicine (Feb 6th-7th), where I gave a talk, and met with Dr. Melissa Suter and Prof. Brett Bouma and their postdoctoral teams. Researchers there also gave me a tour of their laboratories. They showed me prototypes that they had made for clinical applications and shared with me their insights as to how to achieve successful and enhance efficient collaborations with clinicians. Attendees at my talk were very interested in our work on smart needles for safer and more effective brain surgery and on fabricating miniaturized lenses by the 3D printer at CNBP RMIT node, a project that is supported by a CNBP travel grant. Potential future collaborations were also explored.”
“At Polytechnic Montreal (Feb 8th-10th), I met with A/Prof. Caroline Boudoux, a collaborator on our fluorescence-OCT project, as well as postdoctoral researchers of A/Prof. Frederic Leblond. I visited both A/Prof. Leblond’s laboratory and A/Prof. Boudoux’s spin-out company Castor Optics. A technical meeting was held, where we discussed solutions to overcoming technical challenges in our current design. This visit strengthened our existing collaboration.”
A busy time for Jiawen, she also managed to fit in an oral presentation at the SPIE Photonics West 2017 Conference on January 28th , 2017. Her presentation was titled, “Flexible OCT needle probes for image-guided endoscopic tissue aspiration.”
24 July 2016:
CNBP researcher Dr. Jiawen Li has given an invited talk at the Nanchang Hangkong University, China. Two of her current research projects on novel fibre-optic probes and a short description of CNBP activities and projects were presented to attendees.
21 July 2016:
Dr. Jiawen Li, CNBP researcher located at the University of Adelaide, has given an invited talk at the Med-X Research Centre, Shanghai Jiao Tong Univeristy, China. Her visit included discussions on potential collaborations with the Med-X Research Centre, one of the top biomedical engineering research centres in China.
19 July 2016:
Dr. Jiawen Li presented her team’s work at the 8th International Conference on Information Optics and Photonics (CIOP 2016) in Shanghai, July 17-29 and was awarded best poster award.
This award was based on research work by CNBP researchers Jiawen Li, Bryden Quirk, Rodney Kirk, Robert McLaughlin, et al. with the poster titled, “Application of 3D printing technology in manufacturing miniaturized lenses for endoscopic probes.”
2 June 2016:
We welcome several new team members to the CNBP and the University of Adelaide team more generally.
The first is Mr Bryden Quirk, joining us from Perth and who works alongside Chair of BioPhotonics Professor Rob McLaughlin. Bryden is working on the “fibre optical needle imaging” project and sits in the School of Medicine, CNBP and in the Biological Sensing and Medical Diagnostic Theme at the Institute for Photonics and Advanced Sensing (IPAS).
Next up is Dr Jiawen Li, Lecturer, also joining us from Perth, who works with Bryden Quirk and Professor Rob McLaughlin on the project “optical coherence tomography (OCT)” and sits in the School of Medicine, CNBP and in the Biological Sensing and Medical Diagnostic Theme at IPAS.
Welcome! It’s great to have you both on board!