When a couple cannot conceive naturally, they often turn to in-vitro fertilisation. And that’s when the spectre of ‘aneuploidy’ arises — the risk that a fertilised embryo will have an abnormal number of chromosomes instead of the usual 46, triggering a range of congenital disorders, most of which result in miscarriage, stillbirth or death of the baby soon after birth. Continue reading
Prof Brant Gibson and Prof Jeremy Thompson (both CNBP Chief Investigators) have attended (and presented) at the International Embryo Technology Society (IETS) conference held in New Orleans, January 20– 23, 2019.
A lunch presentation session sponsored by CNBP, provided both representatives with the opportunity to talk about CNBP as well as to provide information on the organisation’s latest research and activity, taking place in the imaging and reproduction spaces.
Areas covered included: research on improving in vitro embryo production (IVF) systems; the development of a purpose-built, multi-function, micron-scale embryo ‘housing’ device created via unique 3D-printing technology; discussion on advanced hyperspectral imaging techniques; and the development by CNBP researchers of a clip-on device to enhance the magnification of a mobile phone’s existing optics, enabling bull semen analysis.
“The CNBP presentation went even better than I was expecting and we had over 40 people in attendance,” said Prof Gibson.
“Everyone enjoyed the lunch and there were plenty of questions and discussion from key people in the field, during and after our presentations. ”
“Hopefully this will spark some future collaborations both from a research and translation point of view,” Prof Gibson concluded.
The IETS Conference is the preeminent meeting in animal biotechnology, covering a broad area from embryo production and transfer techniques to cloning and transgenesis. The conference attracted more than 600 attendees from all over the world.
Below: A/Prof Jeremy Thompson discusses use of photonic probes in the reproduction space.
22 November 2016:
Failure to launch: aberrant cumulus gene expression during oocyte in vitro maturation
Hannah M Brown, Kylie R Dunning, Melanie Sutton-McDowall, Robert B Gilchrist,
Jeremy G Thompson and Darryl L Russell
In vitro maturation (IVM) offers significant benefits for human infertility treatment and animal breeding, but this potential is yet to be
fully realised due to reduced oocyte developmental competence in comparison with in vivo matured oocytes. Cumulus cells occupy
an essential position in determining oocyte developmental competence. Here we have examined the areas of deficient gene
expression, as determined within microarrays primarily from cumulus cells of mouse COCs, but also other species, between in vivo
matured and in vitro matured oocytes. By retrospectively analysing the literature, directed by focussing on downregulated genes, we
provide an insight as to why the in vitro cumulus cells fail to support full oocyte potential and dissect molecular pathways that have
important roles in oocyte competence. We conclude that the roles of epidermal growth factor signalling, the expanded extracellular
matrix, cumulus cell metabolism and the immune system are critical deficiencies in cumulus cells of IVM COCs.
Congratulations to A/Prof. Jeremy Thompson (CNBP Chief Investigator at the University of Adelaide) who has given the Founders Lecture at the Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology (SRB), at the Gold Coast Convention Centre, 21st August 2016.
The Founder’s Lecturer is the SRB’s major plenary speaker at the Annual Meeting, with those awarded the Lecture, recognised for their significant contributions to the field of reproduction in Australia.
According to an announcement from the SRB Secretariat, Thompson is a “fantastic asset to the SRB and well deserving of the Founders lecture award,” having been a proactive member of the SRB for over two decades and a “world renowned expert in embryo development.”
Further information about the Annual Meeting is available online.
CNBP Chief Investigator, Jeremy Thompson, has given an invited talk at a European Society of Human Reproduction and Embryology (ESHRE) workshop in Brussels, Belgium (March 3, 2016).
The workshop explored ‘Oocyte maturation: from basics to clinic’ and the title of Jeremy’s talk was ‘Haemoglobin in the antral follicle – an oocyte oxygenation story or not?’
Workshop information can be found online.
CNBP senior researcher Melanie McDowall (pictured) and CNBP Chief Investigator Jeremy Thompson are co-authors on a newly published paper in the Journal ‘Human Reproduction’.
Publication title: Extending prematuration with cAMP modulators enhances the cumulus contribution to oocyte antioxidant defence and oocyte quality via gap junctions.
Authors: H K Li, M L Sutton-McDowall, X Wag, S Sugimura, J G Thompson and R G Gilchrist.
Can bovine oocyte antioxidant defence and oocyte quality be improved by extending the duration of pre-in vitro maturation (IVM) with cyclic adenosine mono-phosphate (cAMP) modulators?
Lengthening the duration of cAMP-modulated pre-IVM elevates intra-oocyte reduced glutathione (GSH) content and reduces hydrogen peroxide (H2O2) via increased cumulus cell-oocyte gap-junctional communication (GJC), associated with an improvement in subsequent embryo development and quality.
The paper is available online.
Jeremy Thompson, CNBP Chief Investigator, has given an invited talk at the 42nd International Embryo Transfer Society (IETS) Annual Conference, Louisville, USA, (January 23-26 2016).
The title of his talk was “Measuring embryo metabolism to predict embryo quality.”
A series of talks were provided by CNBP researchers at the South Australian Health and Medical Research Institute (SAHMRI), as part of the the organisation’s ‘Heart Health Friday Seminar’ program on the 15th May 2015.
Introduced by SAHMRI Heart Health Theme Leader and CNBP Biological Challenge – Inside Blood Vessels Leader, Prof Steve Nicholls, talks about CNBP related activities were provided by the following personnel:
CNBP Director, Prof Mark Hutchinson – The CNBP, a transdisciplinary research journey
CNBP Biological Challenge Spark of Life Leader, Associate Prof Jeremy Thompson – Lighting up the single cell
CNBP Research Fellow, Dr Nisha Schwarz – Understanding the foam cell
CNBP Research Associate, Benjamin Pullen – Imaging nitric oxide inside blood vessels
3 February 2015 – Interdisciplinary and inter-node publication
Accepted in next to no time – CNBP scores our first internode and interdisciplinary Embryo publication
We have just submitted this paper a few days ago and the editor liked it so much that it was immediately accepted! The paper cited below is a result of joint work between Dr Mel McDowall and A/Prof Jeremy Thompson with other embryology co-authors, Prof Andrew Abell and PhD Student Malcolm Purdy (Chemistry Adelaide node of CNBP), and Prof Ewa Goldys (Physics, MQ node of CNBP). Andrew provided unique reagents and Ewa introduced quantitative analysis of the images. The images are also lovely, and Mel made a nice desktop background which we will submit for the journal cover.
This event demonstrates our collective power when we apply our diverse disciplines to a single CNBP biological challenge.
“REDOX and anti-oxidant state within cattle oocytes following in vitro maturation with bone morphogenetic protein 15 and follicle stimulating hormone
Melanie L Sutton-McDowall 1,2, 7, Malcolm Purdey 2; Hannah M Brown 1, Andrew Abell 2; David G Mottershead 1, Pablo D Cetica 3, Gabriel C Dalvit 3, Ewa M Goldys 4; Robert B Gilchrist 1, 6, David K Gardner 5 & Jeremy G Thompson 1, 2
Accepted in Molecular Reproduction and Development. Accepted 3 Feb 2015
6 November 2014: Robinson Research Institute Director’s Award
Congratulations to CNBP Chief Investigator A/Prof Jeremy Thompson who was awarded the Robinson Research Institute Director’s Award for research and service to the Institute