A new review paper from CNBP researchers (lead author PhD student Jagjit Kaur) outlines current research activities on developing assays including biosensors for the detection of glycosylated hemoglobin (HbA1c). Measurement of HbA1c is used for assessing long term glycemic control in individuals with diabetes.
Journal: Biosensors and Bioelectronics.
Authors: Jagjit Kaur, Cheng Jiang, Guozhen Liu.
Abstract: Measurement of glycosylated hemoglobin (HbA1c) is a gold standard procedure for assessing long term glycemic control in individuals with diabetes mellitus as it gives the stable and reliable value of blood glucose levels for a period of 90–120 days. HbA1c is formed by the non-enzymatic glycation of terminal valine of hemoglobin. The analysis of HbA1c tends to be complicated because there are more than 300 different assay methods for measuring HbA1c which leads to variations in reported values from same samples. Therefore, standardization of detection methods is recommended. The review outlines the current research activities on developing assays including biosensors for the detection of HbA1c. The pros and cons of different techniques for measuring HbA1c are outlined. The performance of current point-of-care HbA1c analyzers available on the market are also compared and discussed. The future perspectives for HbA1c detection and diabetes management are proposed.