Tag Archives: Georgios Tsiminis

Single-ring hollow core optical fibers produced

Georgios Tsminis_web9 March 2016:

CNBP researchers have published a paper in Optics Express, reporting on the fabrication of the first extruded hollow core optical fiber with a single ring of cladding holes. The fibers were used to perform Raman sensing of methanol, demonstrating their potential for future fiber sensing applications.

Title:  Single-ring hollow core optical fibers made by glass billet extrusion for Raman sensing.

Authors: G. Tsiminis, K. J. Rowland, E. P. Schartner, N. A. Spooner, T. M. Monro and H. Ebendorff-Heidepriem.

Abstract: We report the fabrication of the first extruded hollow core optical fiber with a single ring of cladding holes, and its use in a chemical sensing application. These single suspended ring structures show antiresonance reflection optical waveguiding (ARROW) features in the visible part of the spectrum. The impact of preform pressurization on the geometry of these fibers is determined by the size of the different hole types in the preform. The fibers are used to perform Raman sensing of methanol, demonstrating their potential for future fiber sensing applications.

The paper is available online.

 

Concordia College visits CNBP

IMG_Georgios-lab_adjustedweb21 September 2015:

Students of Concordia College were left with an improved understanding of nano biophotonics, as well as the opportunities that a science education can provide, following a visit to the CNBP at the University of Adelaide earlier today.

Impressed students were shown around CNBP laboratories by researchers Georgios Tsiminis and Yinlan Ruan, and were also given a number of  presentations, explaining in greater detail what it is that the Centre is hoping to achieve with its multi-disciplinary approach to research.

It is hoped that CNBP visits from Concordia College will be an ongoing activity, helping inspire younger students with a passion for science and technology.

 

 

 

The science of light at Seymour College

Georgios Tsminis_web17 August 2015:

Dr Georgios Tsiminis, Research Fellow at the Centre for Nanoscale BioPhotonics, has presented an overview of research in light and biophotonics for students at Seymour College, Adelaide, in South Australia.

His talk, provided to students from Year 6-12, at the school’s general assembly, focused on the science of light, contributing to the school’s activities related to National Science Week.

Georgios spoke to students about how light can be used as a tool to understand the world around us, with a particular emphasis on the field of BioPhotonics and in vivo detection of early markers of disease.

The aim was to inspire young school children to view physics and photonics as a gateway to becoming involved in exciting transdisciplinary research, beyond the established narrow limits of what physics stands for.

CNBP researchers visit IPHT Jena

IPHT visit13 July 2015:

From the 28th of June to the 3rd of July, Dr Georgios Tsiminis and Dr Erik Schartner from the Adelaide node of the CNBP visited the Institute of Photonic Technology (IPHT) in Jena, Germany, as part of a longer trip that also included oral presentations at the CLEO Europe 2015 International Conference and company visits throughout Germany.

The two CNBP members gave a seminar to the Fiber Optics work on their recent work on comparing different fluorescence optical fibre sensors (Dr Tsiminis) and on optical fibre thermometry for in vivo applications (Dr Schartner), followed by a lab tour of the IPHT fibre fabrication facility and measurement laboratories. They also met up with another CNBP researcher, Dr Herbert Foo, who is on a long-term visit in Jena working on advanced glass-making.

The rest of this long-term visit was spent working at the laboratory of Prof. Dr Juergen Popp, IPHT, a world-renowned expert of Raman spectroscopy for sensing applications. Dr Tsiminis and Dr Schartner worked with with Dr Christian Matthaeus and Dr Sebastian Dochow from the Raman group. Their work involved gaining hands-on experience with some of the optical fibre Raman probes developed within the group and their deployment for in vivo and ex vivo measurements.

Initial experiments were conducted in bacon cuts, highlighting the difference between fat tissue and red meat in terms of their respective Raman spectra, with fat tissue showing the typical lipid Raman signature that was absent in the collagen-rich red meat part of the sample.

Further experiments were then performed inside a sample of rabbit aorta (preserved in formalin) that enabled the monitoring of fat concentration along the length of the aorta, allowing the pinpointing of areas were fat accumulates inside the blood vessel and therefore locations of possible blood narrowing, a big concern for heart disease.

The CNBP researchers also visited the Schott Glas Museum and got an overview of the early stages of high quality and precision glass making, as well as the Optischen Museum Jena, featuring the history of optic technologies through the ages.

Overall this was a very successful and enjoyeable visit to IPHT in Jena that produced the first parts of shared work and expertise with the CNBP collaborators led by Prof. Dr Juergen Popp. This initial work and fruitful discussions set the base for a future collaborative work project on using Raman spectroscopy to monitor cardiovascular health and we look forward to welcoming some of our IPHT colleagues at the CNBP retreat in November.

Image: Researchers in front of the IPHT building in Jena, Germany. From left to right: Dr Georgios Tsiminis (CNBP), Dr Herbert Foo (CNBP), Dr Erik Schartner (CNBP), Dr Stephen Warren-Smith (IPHT), Prof. Dr Hartmut Bartelt (IPHT) and Dr Linh Nguyen (IPAS).

Youth ANZAAS visits CNBP in Adelaide

cnbplogosquare19 July 2015:

CNBP researchers Roman Kostecki, Georgios Tsiminis , Mel McDowall, Peipei Jia, Erik Schartner and Tess Reynolds were happy to host a visiting Youth ANZAAS tour at their laboratories at the University of Adelaide on July 9th, 2015.

Youth ANZAAS  (organised by the Australian and New Zealand Association for the Advancement of Science)  is an annual residential international forum for science students in Years 10 to 12. Every year, students from each State and Territory are selected to participate in science activities and experiences over a period of a week.

These high achieving students with eager minds were excited to be shown around the working CNBP laboratories, and learnt more about the research that is being undertaken by the Centre, from the lectures  that each researcher provided.

Cutting Edge Speaker at Science Teachers Association Conference

georgiostsiminis13 April 2015: CNBP talks to Science Teachers:

Dr Georgios Tsiminis was invited to represent the University of Adelaide at the Science Teachers Association of South Australia Annual Conference and Expo 2015 as an invited Cutting Edge Speaker.  Hosted at Brighton Secondary School with an audience of Science teachers from around South Australia.

The talk was titled “Listening to molecules using light: optical detection of chemicals” and co-authors include Dr Joanna Brooks (ARC Centre for Research on Ageing, Health and Wellbeing at the Australian National University), Nigel Spooner (IPAS), Tanya Monro (UniSA/CNBP), Fenghong Chu (Shanghai University of Electric Power).

 The talk gave an overview of how light can be used as a tool for detecting chemicals in complex samples and focused on using optical fibres as photonic tools for chemical sensing by Raman spectroscopy. Two examples were given, measuring vitamin B12 in the scope of exploring vitamin B12 deficiency as a modifiable risk factor for dementia and Alzheimer’s; and explosives detection, where Raman spectroscopy was performed using microstructtured suspended core optical fibres to enhance the signal and enable the detection of fundamentally different explosives (TNT and hydrogen peroxide) using the same sensor at quantities of less than a microgram. Both examples highlight the great flexibility of photonic technologies for chemical sensing and establish the cross-disciplinary nature of research undertaken within the CNBP, IPAS and the University of Adelaide.

 

Dr Georgios Tsiminis visits Oxford University

georgiostsiminis28 January 2015: Department of Pharmacology, Oxford University.

“Taking a closer look at vitamin B12”, delivered by CNBP researcher Dr Georgios Tsiminis and  co-author Dr Joanna Brooks from the ARC Centre for Research on Ageing, Health and Wellbeing at the Australian National University.

The talk gave an overview on the potential for using Raman spectroscopy as a minimally invasive tool to measure and track vitamin B12 levels in humans. Vitamin B12 deficiency has been identified as a potential modifiable risk factor for dementia and Alzheimer’s disease in later life and is also the mechanism through which pernicious anaemia affects humans (vitamin B12 does not get absorbed through food due to lack of intrinsic factor). Current techniques for measuring vitamin B12 in humans, such as microbial growth and ELISAs, are both resource- and time-consuming, resulting in the general population not being regularly tested for vitamin B12 deficiency. Our aim is to produce a portable device that can measure vitamin B12 and its associated chemical compounds in a reproducible, reliable, fast and minimally-invasive manor. In this talk we explained the basic principles of Raman spectroscopy and showed some initial results that generated great interest at Oxford, who have asked us to keep them up to date with future developments on our work.

To find out a bit more about this presentation see Martyn Hooper’s Blog post “the Blog from  he chair of the Pernicious Anaemia Society.

Nanoparticles, velcro, marbles and a hot glue gun

CNBPat Questacon SciComm event Dec 2014-2

16 December 2014 :Science Communication workshop.
“If you can’t explain it simply, you don’t understand it well enough.” – Albert Einstein.

On December 15-16th, 9 CNBP ECRs from University of Adelaide,  RMIT University, Macquarie University and SAHMRI attended a science communication workshop at the Questacon workshop (Canberra) and were taught the importance of translating their research into lay terms. More specifically, explaining concepts such as the use of nanoparticles for targeted drug therapy to an 8 year old. Its harder than you think and involves the art of scaffolding; i.e. simplifying a concept by using analogies.

The most interactive and fun session of the workshop involved us creating models and physical demonstrations of our research and included us all running around the Questacon workshop to explain current, throwing paper at people as a demonstration of drug delivery, different coloured glow sticks as an analogy for the use of nanoparticles/probes to diagnose pain and the use of lots and lots of velcro and hot glue guns to make “up-scaled” nanoparticles. Think Playschool for scientists.

CNBP were proud to be sponsors of this professional development workshop which was developed by The ARC Centre of Excellence for Electromaterials Science, in partnership with the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology and the ARC Centre of Excellence in Nanoscale BioPhotonics.

The workshop was designed to teach participants how to put their best foot forward in media interviews, community talks and scientific presentations.

IPAS Pilot Project Grants Awarded

3d-printed-extrusion-july-news-img

15 December 2014: Three Grants awarded to CNBP researchers

CNBP resarchers at the University of Adelaide were successful in obtaining three IPAS pilot project grants totaling $45,000

Characterisation of aquaporin-1 (AQP1) ion channel activity in migrating cancer cells using a novel photoswitchable fluorescent probe, Andrea Yool, Sabrina Heng, Jinxin (Victor) Pei, $15K

Rapid phenotyping of human stem cells sub-populations using optical spectroscopy, Georgios Tsiminis, Erik Schartner, Simon Koblar, Mark Hutchinson, $10K

UV-guiding silica hollow-core fibre for biological sensing, Philip Light, Sabrina Heng, Chris Perrella, Heike Ebendorff-Heidepriem, $15K

CNBP researchers shine new light on stroke events inside the brain

Capture3 December 2014:  Publication

Recently published paper from CNBP researchers using optical fibres to monitor the evolution of processes relating to ischaemic stroke by measuring the activation of a fluorescent photosensitive dye inside the brain of living mice in real time.

Researchers from the ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP) have demonstrated that measurements of fluorescent chemicals can be made deep inside the brain of living mice in a project hoping to expand our understanding of the events unravelling during a stroke event. The research was published at Biomedical Optics Express.

Dr Georgios Tsiminis, Dr Erik Schartner, Dr Stephen Warren-Smith and Prof. Tanya Monro from the CNBP, along with Dr Thomas Klaric and Dr Martin Lewis from the Stroke Research Programme led by Prof. Simon Koblar at the South Australian Health and Medical Research Institution (SAHMRI) and the University of Adelaide put together a transdisciplinary research programme, funded by a pilot project grant provided by the Institute for Photonics and Advanced Sensing (IPAS).

This project aimed to extend understanding of what happens during the photochemical stroke model, a rodent stroke model that creates stroke infarcts using a photosensitive organic dye, allowing biomedical researchers to investigate how stroke events occur and what they can do to aid recovery. The existing photochemical stroke model creates stroke infarcts on the surface of the brain as it uses external illumination and any information on what has occurred in the brain can only be determined by post-mortem biopsy.

In this work CNBP researchers used an optical fibre to deliver laser light deep inside the brain at the hippocampus, allowing the controlled creation of stroke infarcts anywhere in the brain. In addition, the same fibre collects the signal from the stroke-inducing dye, allowing the estimation of the dye concentration at the site of the stroke event and the monitoring of the evolution of the dye breakdown in real time.

This is the first time that such measurements have been performed inside the brain of a living animal, highlighting the capabilities of photonics technologies applied to biomedical problems and the novel results they create for researchers in the field.

The original publication can be found at http://dx.doi.org/10.1364/BOE.5.003975.