From capturing images of cellular processes to sensing electromagnetic fields in extreme environments, researchers at the Centre for Nanoscale BioPhotonics are harnessing the unique properties of diamonds for a wide variety of applications. Continue reading →
Georgina Sylvia was trained as a chemist, but teaming up with biologists and physicists is all in a day’s work. At the ARC Centre of Excellence for Nanoscale BioPhotonics, Dr Sylvia uses light to understand minuscule biological changes that can have a big impact on human health. Continue reading →
Dr Christina Bursill is the Centre for Nanoscale Biophotonics’ chief investigator in vascular health. She leads a research group looking at the underlying mechanisms for heart disease and a way to use photonics to detect it early on. Continue reading →
The International Brain Research Organisation’s recent international meeting was a chance for CNBP researchers to present their intense focus on translational research, and highlighted the differences with other approaches. Continue reading →
Professor Dennis Matthews is one of CNBP’s oldest friends, having been coming to Australia from his home in California each year for nearly seven years as a member of its International Science Committee.
“I’ve actually been coming here since before the CNBP inception. They were just getting their act together for the initial grant when I first visited,” he says.
Professor Matthews was trained as physicist, but for most of his working life he has been involved in the development of medical devices.
His multidisciplinary life is reflected in his position as professor at University of California Davis in both the Department of Neurological Surgery and the College of Engineering. He was at one time also director of UC Davis’ Center for Biophotonics, Science, and Technology.
“I was hired into the neurological department not because I knew anything about neurosurgery but because they wanted their physicians to have more opportunity to do early stage research, even before it could be translated to the clinic,” he says.
He “abandoned physics 30 or 40 years ago”, drawn to things that were more hands-on and, around that time, he met a medical doctor who wanted to develop better instrumentation.
“I told him I didn’t know anything about medicine so he should go away. But he didn’t.”
That started a long history of working with doctors and bioscientists to develop technology that helped in their work.
“Biological scientists are incredibly smart at what they do but they are not so smart at measuring it,” he says.
“I don’t know what their problems are, of course, so they tell me what they are trying to achieve and I tell them ways to get at the solutions to their problems – and we help each other along the way.
“What I like about it, and CNBP works very nicely in this respect, is that you ‘bootstrap’ it. I tell the bioscientists I can do something but I’m not quite sure I know how to do it. So they challenge me to make technology progress at the same time.”
He believes CNBP has some unique strengths – “I wouldn’t travel around 13,000km to come here otherwise”.
He was first introduced to the centre by the inaugural director, Professor Tanya Munro. “I thought she had an extremely good vision of where all this could go and perhaps an even better way of communicating that vision.” Since then, he says, current director Professor Mark Hutchinson has emerged as an incredible thought leader as well.
Professor Matthews says he likes the way the CNBP brings themes together and its “Mission Impossible” approach to throwing multidisciplinary teams of experts at problems.
As a technologist he was also drawn to the IPAS fibre optics group, and the way it was developing fibre sensors to interrogate places that might otherwise be invisible.
Two biological research themes particularly interested him.
“Many of the things here are important to me but there were two that were exceptional and that was Mark’s [Hutchinson] work on neuroscience applied to pain, and particularly his interest in developing a “painometer”.
He was also attracted to the IVF research under Chief Investigator Professor Jeremy Thompson.
“My daughter had two children by IVF and so my interests were already a bit piqued. But I was also interested to see if we could make the whole thing work better.”
Secondly was the possibility of making sure the highest quality embryos were developed and then implanted.
“That whole notion was extremely fascinating and provocative to me,” he says. “I think that we are going to learn how to make embryos healthier in normal conception. And if we can make the healthiest baby possible it can lead to a lifetime of good health.”
Personal experience also lay at the heart of his interest in Professor Hutchinson’s work on pain, which, while important to help people cope at a personal level, he sees as a potential solution to the opiate crisis.
“At the moment we are only delivering pain-masking drugs,” he says. “These powerful drugs don’t do anything except make people not care if they hurt – they still hurt.”
He is helping with the task of looking for biomarkers that might underpin such a measuring device.
“I think it’s possible, but I don’t know yet what the right measurements are,” Professor Matthews says. “And the problem with humans is there is no single recipe, so if we do get a panel of biomarkers that said my pain level was 6 it could be completely wrong for you.
“So we need some way to normalise it so we can say this is a baseline for an individual.”
Professor Matthews is particularly drawn to the CNBP’s focus on envisioning the ultimate translation of the technology.
“So instead of just filling the journals with more manuscripts it is also important in biosciences that you keep in mind that your work will, in the end, actually affect patients.
“The question we should always be asking is ‘how do we get doctors to have the latest technologies to work with?’.”
The current academic landscape demands ‘Publish or Perish’, but how do you make sure your publication stands out from the rest? Luckily for us, CNBP has identified this issue and developed a residential masterclass with a dual purpose of giving young researchers the opportunity to workshop a range of different manuscripts while growing team culture. Continue reading →
CNBP researcher Dr James Quach is working on a quantum battery which, if he can demonstrate it works as the theory suggests, could revolutionise how fast we can charge electronic devices. Continue reading →
The CNBP and its researchers are taking part in a wide range of activities for National Science Week.
This Thursday 8 August researcher Dr Wei Deng from UNSW Sydney will explain how nanotechnogy is changing how we treat cancer, as part of Inspiring Australia’s Talking Science series.
It will be held at the Max Webber Library, in Blacktown, Sydney. More details here.
On Sunday, 11 August, Adelaide University’s Lyndsey Collins-Praino will host Kids Navigate Neuroscience, an event at which children aged 4-10 can explore how the brain works in a fun and hands-on way by participating in a series of interactive neuroscience exhibits.
You can find out more about the event here. Bookings are essential and can be made through Eventbrite.
On Tuesday 13 August explore medical brain research by joining Dr Lindsay Parker, a researcher at Macquarie University, as she discusses how she is trying to create better medicines for Alzheimer’s, chronic pain and brain cancer, by only targeting the unhealthy cells in the brain. This event is part of Inspiring Australia’s Talking Science series as part of National Science Week. Bookings available now. Contact details:
Castle Hill Library
The Hills Shire Library Service
Phone: 02 9761 4510 https://www.scienceweek.net.au/exploring-medical-brain-research/
There is a fun evening next Friday, 16 August, at the Adelaide Medical School, University of Adelaide, where you can explore the neuroscience of sex, drugs and salsa dancing.
A series of interactive exhibits will address questions such as, what role does the brain play in sexual attraction? Can you salsa dance your way to a healthy brain? How does the brain perceive different flavours when drinking wine, and how can pairing wine with different foods alter this perception?
Also next Friday, 16 August, the whole family is invited to see some amazing short videos on a massive screen in a free National Science Week Event hosted by STEMSEL Foundation Braggs Lecture Theatre, University of Adelaide AI Light Science Spectacular.
You will find out how the eye works, how NASA finds planets in other solar systems and how detected the edge of the Universe.
You will also explore light, from nanoscale biophotonics with CNBP research fellow Dr Roman Kostecki to exploring the Universe with Dr Jerry Madakbas, a photonics physicist who builds night vision sensors for NASA.
What role does the brain play in sexual attraction? Can you salsa dance your way to a healthy brain? How does the brain perceive different flavours when drinking wine, and how can pairing wine with different foods alter this perception?
These days, you can’t seem to walk through the aisle of a grocery store without being bombarded by newspaper and magazine headlines touting the latest and greatest breakthrough in neuroscience research. But how can you tell fact from fiction?
Join us for this Big Science Adelaide event, held at the Adelaide Health and Medical Sciences (AHMS) building at the University of Adelaide, where we’ll explore the answers to these questions and many more!