Category Archives: MQ

CNBP-ANSTO workshop

CNBPlogoSquare8 December 2016:

CNBP’s Macquarie University node hosted researchers from the Australian Nuclear Science and Technology Organisation (ANSTO) at a highly successful full day workshop held on the 8th December, 2016.

The workshop was an opportunity to showcase current imaging and sensing research from both organisations, to stimulate discussion and to see where collaboration opportunities might potentially lie in the future.

In a full and impressive program, ANSTO team members and their research topics presented included:

1. Marie-Claude Gregoire – who provided a team overview and introduction
2. Ben Fraser – multi-modal probes
3. Paul Callaghan – in vivo & post mortem multi-modality imaging
4. Mitra Safavi-Naeni – imaging quantification
5. Catriona Wimberley – in vivo kinetic modelling

CNBP researchers Arun Dass, Guozhen Liu, Helen Xu, Wei Deng, Nima Sayyadi, Andrew Care, Nicole Cordina, Varun Sreenivasan, Lianmei Jiang and Ayad Anwer also delivered talks on their areas of research and expertise.

Below – workshop attendees ready for an exciting day of presentations and discussion!

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New PhD student at Macquarie Uni node

rachit_bansal-18 December 2016:

CNBP’s Macquarie University node welcomes PhD student Rachit Bansal to the team.

Rachit has a Master’s in Nanotechnology from VIT University, Vellore, India, where he worked on the synthesis and properties evaluation of different conducting, insulating, semiconducting and superconducting oxides.

Later he worked at the National University of Singapore in the area of Biochemistry exploring the cross-link efficiency of siderophores (especially enterobactin) in order to design non-leachable anti-fungal wound dressings.

Rachit will work under supervision of CNBP Associate Investigator A/Prof Anwar Sunna and Centre Research Fellow Dr Andrew Care.

His project is aimed at understanding the binding mechanism of a unique solid-binding peptide displaying binding affinity to a diverse range of silica-based materials.

Deputy Director presents at Wagga Wagga

Ewa Goldys Low Res Edit 015929 November 2016:

CNBP Deputy Director Prof Ewa Goldys has given a talk at the School of Biomedical Sciences, Charles Sturt University, Wagga Wagga on her research success “A Eureka Moment for Cell Colour Technology.”

The talk results from Prof Goldys being awarded the recent Australian Museum Eureka Prize for ‘Innovative Use of Technology’.

Prof Goldys, together with Dr Martin Gosnell, developed a hyperspectral imaging technique that allows for the successful extraction of specific biomolecular information hidden in fluorescent colour signatures of living cells and tissues.

The talk examined the technology and the real world translational outcomes that will result from this exciting area of study that will support clinicians in making improved diagnosis and health decisions for patients.

 

New CNBP PhD student

OLYMPUS DIGITAL CAMERA28 November 2016:

CNBP welcomes its newest PhD student at Macquarie University – Fei Deng.

Fei is undertaking his PhD study on the development of a biosensor for cytokine testing and is being supervised by Centre Deputy Director Professor Ewa Goldys and A/Prof Guozhen Liu.

Fei gained his Master’s Degree this year at the Korea University of Technology and Education (the Department of Chemical Engineering) with his Bachelor Degree undertaken at Tianjin Polytechnic University (within the Department of Material Science and Engineering).

His research interests lie in the field of device design and biosensor materials synthesis, especially related to cytokines. And his background is primarily in materials science and engineering.

Great to have you on board Fei!

 

NeuRA Invited Seminar Series

Ewa Goldys Low Res Edit 015925 November 2016:

Professor Ewa Goldys, Deputy Director of the CNBP, has given an invited talk at the Neuroscience Research Australia (NeuRA) Invited Lecture series, 25th November 2016, Sydney.

The talk was titled “A Eureka moment for cell colour technology” and explored the research behind Prof Goldys and her success in being awarded the 2016 Australian Museum Eureka Prize for ‘Innovative Use of Technology’.

Professor Goldys and her team were recognised for their innovative colour-focused research (and pioneering hyperspectral imaging technique), able to distinguish between healthy and diseased cells, in areas as diverse as embryology, neurodegeneration, cancer and diabetes.

Real-world translational outcomes that will result from this exciting area of study, that will support clinicians in making improved diagnosis and health decisions for patients, was also discussed.

The NeuRA lecture series attracts leading national and international researchers from all fields of neuroscience.

 

PLGA nanocomposites developed for PDT of cancer cells

staff photos for Centre of Excellence in Nanoscale Biophotonics (CNBP)24 November 2016:

In this latest paper, CNBP researchers (lead author Wei Deng pictured left) developed PLGA nanocomposites by incorporating a photosensitizer, verteporfin and gold nanoparticles into the polymeric matrix and utilised them for enhanced photodynamic therapy of cancer cells.

Journal: RSC Advances.

Title: PLGA nanocomposites loaded with verteporfin and gold nanoparticles for enhanced photodynamic therapy of cancer cells.

Authors: Wei Deng, Zofia Kautzka, Wenjie Chen and Ewa M Goldys.

Abstract: In this paper, PLGA nanocomposites were developed by incorporating a photosensitizer, verteporfin and gold nanoparticles into the polymeric matrix and utilised for enhanced photodynamic therapy of cancer cells. Both enhanced fluorescence and O2 generation from verteporfin were observed in this new formulation under both 425 nm LED and 405 nm laser illumination. A maximum enhancement factor of 2.5 for fluorescence and 1.84 for O2 generation was obtained when the molar ratio of gold : VP was 5:1 and excited at 425 nm, compared with PLGA doped with verteporfin alone. The experiment results could be explained by the local electric field enhancement of gold nanoparticles. Furthermore, improved therapeutic efficacy in human pancreatic cancer cells, PANC-1, was also demonstrated by using this new formulation following light exposure, indicating the utility of these nanocomposites for enhanced photodynamic therapy.

The paper is accessible online.

Welcome Fang Gao

OLYMPUS DIGITAL CAMERA24 November 2016:

The Macquarie University node of CNBP welcomes PhD student Fang Gao to the team.

Fang is undertaking her PhD on real-time sensing for cytokines and is being supervised by Center Deputy Director Prof. Ewa Goldys and Centre Research Fellow A/Prof. Guozhen Liu.

Fang’s research interests lie in the field of fluorescent sensing of biomolecules and biological imaging. Her background is primarily in Analytical Chemistry and Material Science.

Prior to joining Macquarie University, Fang completed her Master of Medicine in Pharmaceutical Sciences from the South-Central University for Nationalities, China. She worked under the guidance of A/Prof. Dan Zhao, where she synthesized a series of novel water-soluble quantum dots and conducted a chiral sensing for tyrosine enantiomers.

Her career goal in the near future is to help construct a device which can detect  cytokines in vivo in real time.

Olympus visits CNBP at Macquarie University

OLYMPUS DIGITAL CAMERA23 November 2016:

Centre personnel, laboratories and microscopes were on display at Macquarie University, Wednesday November 23rd, as guests from industry partner Olympus Australia took time out of their busy schedules to visit and to explore the latest in imaging developments taking place at the CNBP.

Hosted by CNBP node leader Prof Jim Piper and CNBP Associate Investigator Dr Yiqing Lu, Olympus Australia’s Kim Everuss (Sales Manager, MIS), Jian Shen (Marketing Manager, MIS), Chunsong Yan (Customer Experience Service Manager) and Clare Kelly (Product Manager specialising in confocal microscopy) were shown the latest in CNBP research, spoke with CNBP researchers and actively inspected tools and techniques related to the Centre’s luminescence related microscopy activity. Of particular focus was Centre work on a ‘plug and play’ time-gated imaging module that could be easily linked to current Olympus microscope setups.

Presentations from CNBP researchers also took place during the visit, outlining biological applications including biomedical diagnostics and drug delivery and leading edge research in the biology of pain.

Prof Jim Piper noted that the visit further cemented the fantastic relationship between the two organisations and that he looked forward to working closely with Olympus Australia with a view to facilitating industry-research benefits for both parties.

Below –  CNBP Associate Investigator Dr Yiqing Lu explains the technology involved in the innovative time-gated imaging module.

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New student at CNBP MQ node

OLYMPUS DIGITAL CAMERA22 November 2016:

CNBP’s Macquarie University node welcomes PhD student Vlada Rozova  to the team.

She is undertaking her PhD on the mathematical modelling of tumour growth in tissue engineering constructs and is being supervised by CNBP Associate Investigator A/Prof. Andrei Zvyagin.

Vlada’s research interests lie in the field of mathematical modelling of biomedical problems, especially related to cancer. and her background is primarily in Applied Mathematics and Computer Science.

Last year she graduated from the Department of Computational Mathematics and Cybernetics of Lomonosov Moscow State University, Russia. While there, and under  the supervision of Prof. Alexander Bratus, she developed a mathematical model of interactions between tumours and the immune system in the presence of chemotherapy. Computational methods were applied to solve a constrained optimisation problem and to find an optimal strategy of therapy.

After graduation Vlada spent a year working in a company providing model-based drug development solutions for global pharmaceutical companies and acquired experience in quantitative systems pharmacology, pharmacokinetic-pharmacodynamic and population modelling.

The goal of her PhD project is to develop a reliable mathematical model of tumour invasion validated by the experiments conducted in her group.

Welcome Vlada! It’s great to have you here.