Tiny structures called nanocages have the potential to revolutionise treatment of conditions like Parkinson’s and Alzheimer’s diseases.
Two researchers, seemingly worlds apart: one a nanoscientist, the other a neuroscientist. Born in different hemispheres with labs in different states, at the start of their game-changing collaboration 2 years ago, they felt they were speaking different languages. Continue reading →
When the Reserve Bank of Australia wanted to develop new security technologies for bank notes, Prof Jim Piper’s Advanced Imaging research group in the ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP) at Macquarie University had an answer: timecoded nanoparticles. Continue reading →
Medical researchers face a hurdle when studying cells under an optical microscope — the laws of physics. Obtaining an image of anything below a certain size is complicated; optical apertures and the wavelength of visible light play havoc with clarity. Known as the diffraction limit, it was first encountered by German physicist Ernst Abbe in 1873, and limits the resolution to 200 nanometres (nm) at best (or 200 billionths of a metre). Continue reading →
Pancreatic cancer is one of the most lethal cancers, but difficult to diagnose: few sufferers have symptoms until the cancer has become large or already spread to other organs. Even then, symptoms can be vague and easily misconstrued as more common conditions. Continue reading →
For Dr Andrew Care, tiny structures inside living bacteria may hold the key to tackling many diseases. Shaped like miniature soccer balls, these protein nanocages can be modified to accomplish a wide range of tasks, from helping microbes cope with environmental stress to delivering drug payloads inside cancer cells. Continue reading →
Pain: we all experience it, but there’s no objective way to measure it. Sure, you can nominate what it feels like on the 10-point ‘pain scale’ used by doctors; but one man’s pain may be another woman’s discomfort. Continue reading →
Last week saw CNBP researchers come together from around the country for the annual conference in Adelaide.
The week culminated in gala where researchers were recognised for their achievements through awards ranging from academic excellence to commercial impact, outreach and collaboration.
Read about the awardees below, and congratulations to all our members who were recognised for their achievements in 2019!
2019 Academic Excellence Award Transdisciplinary Research Publication
Awarded to the best 2019 publication connecting CNBP researchers from multiple disciplines. This year’s award recognises a collaboration between researchers working with nanoparticles, microscopy, computational imaging and molecular & cellular biology.
Denkova, D., M. Ploschner, M. Das, L. M. Parker, X. Zheng, Y. Lu, A. Orth, N. H. Packer and J. A. Piper (2019). “3D sub-diffraction imaging in a conventional confocal configuration by exploiting super-linear emitters.” Nat Commun 10(1): 3695.
2019 Academic Excellence Award – International Impact
Awarded to the best 2019 publication connecting CNBPs Australian researchers with International Partners. This year’s award recognises collaboration between researchers at RMIT University and QST, Japan.
Capelli, M., A. H. Heffernan, T. Ohshima, H. Abe, J. Jeske, A. Hope, A. D. Greentree, P. Reineck and B. C. Gibson (2019). “Increased nitrogen-vacancy centre creation yield in diamond through electron beam irradiation at high temperature.” Carbon 143: 714-719.
2019 Academic Excellence Award – Best Student Publication
Awarded to the best 2019 publication first authored by a CNBP student as determined by journal impact factor.
Wei, Y., H. Ebendorff‐Heidepriem and J. Zhao (2019). “Recent Advances in Hybrid Optical Materials: Integrating Nanoparticles within a Glass Matrix.” Advanced Optical Materials. DOI: 10.1002/adom.201900702
2019 Academic Excellence Award – Best Researcher (non-student) Publication
Awarded to the best 2019 publication as determined by journal impact factor.
Jia, P., K. Zuber, Q. Guo, B. C. Gibson, J. Yang and H. Ebendorff-Heidepriem (2019). “Large-area freestanding gold nanomembranes with nanoholes.” Materials Horizons 6(5): 1005-1012. DIO:10.1039/c8mh01302k
Awarded to the 2019 publication recognised by the wider non-academic community, as determined by Altmetric score.
Habibalahi, A., C. Bala, A. Allende, A. G. Anwer and E. M. Goldys (2019). “Novel automated non invasive detection of ocular surface squamous neoplasia using multispectral autofluorescence imaging.” Ocular Surface. DOI:10.1016/j.jtos.2019.03.003
Awarded to Patrick Capon (@PatCapon) for his diverse, informative and entertaining engagement with the @CNBPscience twitter handle.
2019 Quality Communication Award – Engagement in Centre Outreach Activity
Awarded to Dr Lindsay Parker for community engagement activities including: Science in the Swamp, Exploring Brain Research at Castle Hill Library; and multiple engagements with school groups in Sydney and her home town in the USA.
2019 Nurturing Environment Award – Mentor
Awarded to Professor Andrew Greentree for commitment to mentorship and contribution to CNBP professional development activities including the PhD Publication’s Masterclass, Research integrity training and supporting fellowship applications.
2019 Nurturing Environment Award – 5% Commitment to CNBP
This award recognises individuals that go above and beyond CNBPs requirement for researchers to commit 5% of their time to non-research activities. Awarded to Dr Georgina Sylva for ongoing commitment to science outreach in regional and remote communities.
2019 Commercial Impact Award – Individual Engagement with Industry/End-users
Awarded to a CNBP researcher for successful collaboration with industry and end-users. Prof Heike Ebendorff-Heidepriem for her disruptive glass projects with multiple industry partners and her collaborations with the glass-art community.
2019 Commercial Impact Award – CNBP Project
Awarded for the most successful CNBP research project – industry collaboration. Dr Thomas Avery and Associate Professor Peter Grace for next gen non-opioid non addictive pain therapies.
CNBP pitch fest is the brain child of the ECR led Entrepreneurs Network. After participation in a CNBP-led pitching workshop, Individuals pitch their idea/project to the wider CNBP community with pitches judged by an expert panel.
Equal first prize:
Mr Suliman Yagoub: Towards Automation of in vitro Fertilization (IVF) Treatment.
Current IVF success requires skilled embryologists to perform regular, routine procedures. By automating and standardizing IVF procedures we will reduce human error for IVF treatments world-wide
Dr Andrew Care and A/Prof Lyndsay Collins-Praino: Intercepting Parkinson’s Disease
This novel technology employs bioengineered nanoparticles to halt the progression of Parkinson’s Disease inside the human brain.
2019 Annual Conference – Best Poster Award
Awarded to the best CNBP conference poster by popular vote. Aimee Horsfall – Poster: Enhancing protein biosensor sensitivity requires detailed structural insight.
2019 Director’s Award
Each year the Prof Mark Hutchinson identifies the individual(s) who’s contribution to the centre and/or support to the Director has stood out. Joint award to the CNBP Deputy Directors: Prof Brant Gibson & Prof Ewa Goldys for all-round awesome!
Researchers have found a way to identify multiple cell signalling proteins using a single cell rather than the billions of cells used previously.
The new measurement technology, developed by researchers at the ARC Centre of Excellence for Nanoscale Biophotonics, brings precision medicine a step closer.
“Cells secrete various messenger molecules, such as cytokines. They may indicate the presence of a disease or act as a driver of key therapeutic effects,” says Dr Guozhen Liu, lead author of paper detailing the technology.
The method, termed OnCELISA, uses antibodies attached on specially engineered cell surfaces to capture cytokine molecules before they have a chance to disperse away from the cell.
The secreted messenger proteins such as cytokines are reported, at the single cell level, by using fluorescent magnetic nanoparticles.
Cytokines secreted from cells play a critical role in controlling many physiological functions, including immunity, inflammation, response to cancer, and tissue repair.
The OnCELISA system can be used for ultrasensitive monitoring of cytokine release by individual cells, and it can also help discover cell populations with therapeutic value.
“The ability to identify and select cell populations based on their cytokine release is particularly valuable in commercial cell technologies and it can help develop unique products, such as future non-opioid pain relief” says Dr Liu.
“Importantly, our design uses commercially available reagents only, so it can be easily reproduced by others,” she adds.
While the published work focuses on specific proinflammatory cytokines IL-6 and IL-1β, the method is potentially suitable for a broad range of other secreted proteins and cell types.
The new technique represents an advance on traditional methods such as the enzyme-linked immunosorbent assays (ELISA) that detect average levels of secreted molecules from cell ensembles.
The OnCELISA takes the ELISA approach to its absolute extreme, by detecting cytokines on the surface of individual, single live cells.
Publication Title: A Nanoparticle-Based Affinity Sensor that Identifies and Selects Highly Cytokine-Secreting Cells
Authors: Guozhen Liu; Christina Bursill; Siân P.Cartland; Ayad G.Anwer; Lindsay M.Parker; Kaixin Zhang; Shilun Feng; Meng He; David W.Inglis; Mary M.Kavurma; Mark R.Hutchinson; Ewa M.Goldys
Summary: We developed a universal method termed OnCELISA to detect cytokine secretion from individual cells by applying a capture technology on the cell membrane. OnCELISA uses fluorescent magnetic nanoparticles as assay reporters that enable detection on a single-cell level in microscopy and flow cytometry and fluorimetry in cell ensembles. This system is flexible and can be modified to detect different cytokines from a broad range of cytokine-secreting cells. Using OnCELISA we have been able to select and sort highly cytokine-secreting cells and identify cytokine-secreting expression profiles of different cell populations in vitro and ex vivo. We show that this system can be used for ultrasensitive monitoring of cytokines in the complex biological environment of atherosclerosis that contains multiple cell types. The ability to identify and select cell populations based on their cytokine expression characteristics is valuable in a host of applications that require the monitoring of disease progression.
CNBP researchers have developed a new method of detecting multiple cytokines – the body’s messenger proteins – in very small volume samples, which could lead to earlier diagnosis of diseases such as lymphoma. Continue reading →