An advanced new method has been developed by CNBP researchers that may open the door to 3D microscopy in hard-to-reach areas of the human body.
It sees the successful miniaturization of a 3D imaging technique called ‘light field imaging’, taken to extreme new levels, making in-body application possible.
It could find significant application in diagnostic procedures called optical biopsies, where suspicious tissue is investigated during medical endoscopic procedures.
Reported in the journal ‘Science Advances’, project lead of the innovative imaging approach is Dr Antony Orth, Research Fellow at the RMIT University node of the CNBP (pictured).
The paper can be accessed below or read the media release here.
Journal: Science Advances.
Publication title: Optical fiber bundles: Ultra-slim light field imaging probes.
Authors: A. Orth, M. Ploschner, E. R. Wilson, I.S. Maksymov and B. C. Gibson.
Abstract: Optical fiber bundle microendoscopes are widely used for visualizing hard-to-reach areas of the human body. These ultrathin devices often forgo tunable focusing optics because of size constraints and are therefore limited to two-dimensional (2D) imaging modalities. Ideally, microendoscopes would record 3D information for accurate clinical and biological interpretation, without bulky optomechanical parts. Here, we demonstrate that the optical fiber bundles commonly used in microendoscopy are inherently sensitive to depth information. We use the mode structure within fiber bundle cores to extract the spatio-angular description of captured light rays—the light field—enabling digital refocusing, stereo visualization, and surface and depth mapping of microscopic scenes at the distal fiber tip. Our work opens a route for minimally invasive clinical microendoscopy using standard bare fiber bundle probes. Unlike coherent 3D multimode fiber imaging techniques, our incoherent approach is single shot and resilient to fiber bending, making it attractive for clinical adoption.