Monthly Archives: April 2019

Binding mechanisms of solid-binding peptides

5 April 2019:

A new review article by CNBP PhD student Rachit Bansal and CNBP Associate Investigators (Anwar Sunna, Andrew Care and Tiffany Walsh) reports on experimental tools to study the binding mechanism of synthetic peptides to solid materials. The review provides insights into the role of these peptides as molecular building blocks for nanobiotechnology.

Journal: New Biotechnology.

Publication title: Experimental and theoretical tools to elucidate the binding mechanisms of solid-binding peptides.

Authors: Rachit Bansal, Andrew Care, Megan S. Lord, Tiffany R. Walsh, Anwar Sunna.

Abstract: The interactions between biomolecules and solid surfaces play an important role in designing new materials and applications which mimic nature. Recently, solid-binding peptides (SBPs) have emerged as potential molecular building blocks in nanobiotechnology. SBPs exhibit high selectivity and binding affinity towards a wide range of inorganic and organic materials. Although these peptides have been widely used in various applications, there is a need to understand the interaction mechanism between the peptide and its material substrate, which is challenging both experimentally and theoretically. This review describes the main characterisation techniques currently available to study SBP-surface interactions and their contribution to gain a better insight for designing new peptides for tailored binding.

Non-invasive assessment of islet cells

2 April 2019:

Professor Ewa Goldys, CNBP Deputy Director, UNSW Sydney,  in partnership with Associate Professor Shane Grey from the Garvan Institute have received an international grant from JDRC  for “Noninvasive assessment of islet cells”.

This project will develop a non-invasive method for real-time monitoring of encapsulated beta cells in vitro and in vivo.  This will help assess the fate of implanted cells and define the conditions required to produce high quality insulin-producing cells for implantation and their precursors.

The results will lay the foundations for in vivo assessment of islet transplantation success.

Henan University visit

Prof Jim Piper2 April 2019:

CNBP Chief Investigators at Macquarie University, Prof Jim Piper and Prof Nicole Packer, as well as CNBP Associate Investigator Dr Bingyang Shi have met with delegates from Henan University led by Prof. Yang Zhonghua, Deputy Vice Chancellor and Henan University Vice President.

Henan University, founded in 1912, is located in Kaifeng, China and is known globally for its strength in the Biology discipline. Discussed at the meeting were CNBP research areas and projects, as well as the potential for collaboration. Prof. Piper and Prof. Packer were invited to visit Henan University for further talks later in the year.

L to R – Prof Nicole Packer, Prof. Yang Zhonghua, Prof Jim Piper and Dr Bingyang Shi.