Modulation of the nano-environment

15 November 2018:

A new CNBP research publication (lead author Dr Roman Kostecki, University of Adelaide) describes how molecular interactions can be modulated by defining the local nano-environment to give a specific chemical outcome.

Journal: ACS Applied Materials and Interfaces.

Publication title: Control of Molecular Recognition via Modulation of the Nanoenvironment.

Authors: Roman Kostecki, Sabrina Heng, Adrian M. Mak, Heike Ebendorff-Heidepriem, Tanya M. Monro, and Andrew D. Abell.

Abstract: Many biological processes are driven by the interaction of a host with a guest molecule. We show such interactions can be modulated by carefully defining the local molecular environment to give a specific chemical outcome. Particularly, the selectivity of a host toward two different ions (Ca2+ and Al3+) is defined by it being in solution or the physisorbed state. In solution, the host displays greater selectivity toward Ca2+. When physisorbed, the selectivity profile of the host is reversed with enhanced binding of Al3+. This demonstrates a single host molecule can be tailored to selectively bind multiple guests by altering its nanoenvironment.