Engineering protein-based nanoparticles

23 July 2018:

A new review paper has been published in the journal ‘Genes’ featuring two CNBP Associate Investigators as co-authors, Dr Andrew Care (Cancer Institute NSW) and Dr Anwar Sunna (Macquarie University).

Titled, ‘Bioengineering Strategies for Protein-based Nanoparticles’, the paper focuses on the tools available to custom-engineer protein-based nanoparticles for different applications, including those in nanomedicine and biotechnology.

First author of the paper, and co-supervised by Dr Care and Dr Sunna is Ms Dennis Diaz (pictured left in photo).

Journal: Genes.

Publication title: Bioengineering Strategies for Protein-Based Nanoparticles.

Authors: Dennis Diaz, Andrew Care and Anwar Sunna.

Abstract: In recent years, the practical application of protein-based nanoparticles (PNPs) has expanded rapidly into areas like drug delivery, vaccine development, and biocatalysis. PNPs possess unique features that make them attractive as potential platforms for a variety of nanobiotechnological applications. They self-assemble from multiple protein subunits into hollow monodisperse structures; they are highly stable, biocompatible, and biodegradable; and their external components and encapsulation properties can be readily manipulated by chemical or genetic strategies. Moreover, their complex and perfect symmetry have motivated researchers to mimic their properties in order to create de novo protein assemblies. This review focuses on recent advances in the bioengineering and bioconjugation of PNPs and the implementation of synthetic biology concepts to exploit and enhance PNP’s intrinsic properties and to impart them with novel functionalities.