Monthly Archives: December 2017

Multi-LED light source for hyperspectral imaging

15 December 2017:

A multi-LED light source has been investigated by CNBP researchers for use in hyperspectral imaging. The research featured in the journal ‘Optics Express’  with the lead author on the paper, PhD student Kashif Islam, based at Macquarie University.

Journal: Optics Express.

Publication titleMulti-LED light source for hyperspectral imaging.

Author: Kashif Islam, Martin Ploschner, and Ewa M. Goldys.

Abstract: We investigate a novel light source design for efficient collection of UV light from multiple LEDs. The design is based on a truncated cone with a large circular lid incorporating LEDs on one side, and a small circular exit aperture (diameter of 9 mm) on the other side. The exit aperture size allows a simple coupling with secondary optics of a microscope for hyperspectral imaging that requires a wide spectrum of frequencies of illuminating light. The light collection efficiency was optimized with respect to cone length and diameter of the LED lid. In all simulations, we use a highly UV-reflecting aluminum coating on the inner surfaces of the cone. The influence of the LED positions on the cone efficiency is determined by varying the LED distance from the central axis as well as the interLED distance. We found the maximum efficiency of the cone is realized for LEDs positioned at the center, and the shorter is the inter-LED distance, the better is the performance of the light source.

Nanoscale biophotonics for the ‘other’ brain

12 December 2017:

CNBP Director Prof Mark Hutchinson, The University of Adelaide has published a new review and commentary on the future of sensor development in the exciting new world of neuroimmunoscience!

Journal: Microelectronic Engineering.

Publication titleThe importance of knowing you are sick: Nanoscale biophotonics for the ‘other’ brain.

Author: Mark R. Hutchinson.

Abstract: A great new frontier in biomedical science has recently been discovered that requires the attention of technologists from diverse backgrounds to equip scientists with the tools needed to explore this great uncharted area. This new expanding domain is the exploration of the neuroimmune cells of the central nervous system, and their real-time function and contributions to the health and disease of the brain and spinal cord. Glia, once thought of as mere structural supports for the brain, are now appreciated to actively contribute to brain function. However, the true complexity of this system is still hidden from close examination, owing to a range of technological and methodological limitations. Here, some of these opportunities and challenges are outlined to expose the micro and nanoengineering community to this dynamic area of research, and to encourage innovation and technology application in the research of the “other brain”.

Science meets art

11 December 2017:

Science met art as researchers from CNBP and the Institute for Photonics and Advanced Sensing (IPAS) visited the ‘Quantum Colour: Capturing The Movement Of Light’ exhibition at Adelaide’s JamFactory and got a back-stage tour with artist and Creative Director of JamFactory Glass Studio, Karen Cunningham.

The exhibition, melding science with traditional glass blowing techniques features Cunningham’s works and sees her explore nanoparticles as a primary constituent of how light may be subverted or augmented in hand-made glass art. Her glass works were inspired by meetings and interactions with CNBP and IPAS researchers over the course of the year.

CNBP Director, Prof Hutchinson believes that scientists and artists are more alike than different and that the two have a lot that they are able to share. “When science and art collide it means scientists and artists can share their inspirations, get creative and produce fantastic and innovative outcomes.”

Further information on the exhibition, Karen Cunningham and her engagement with CNBP science can be read online in an article in the Adelaide Review.

Below – one of the glass works being exhibited at JamFactory.

ARC CEO visits CNBP laboratories

10 December 2017:

Professor Sue Thomas, Chief Executive Officer (CEO) of the Australian Research Council (ARC) has visited CNBP laboratories at the University of Adelaide and gained  first-hand experience of the exciting biophotonics science taking place there.

Shown around a number of laboratory spaces by CNBP Director Prof Mark Hutchinson, Prof Thomas spent time examining the glass fabrication facilities used by the Centre as well as exploring more fully, the exciting ‘smart needle brain probe’ work headed-up by Prof Robert McLaughlin.

Other CNBP related activity included discussion with Centre researchers of industry relevant translational work currently being undertaken in the food and wine quality assessment area.

Prof Mark Hutchinson said of the visit , “It was fantastic to share with Prof Thomas how the breadth of our ARC funded CNBP fundamental science program is translating to industry projects and how this is leading to new leveraged funding and employment opportunities for our talented CNBP scientists.”

Below – ARC CEO Prof Sue Thomas is given a hands-on demonstration of a ‘smart needle’ probe for the brain by CNBP’s Prof Robert McLaughlin.

Annual CNBP conference jam-packed!

4 December 2017:

The CNBP research community (Chief investigators, Associate Investigators, researchers, students and members of the International Science Committee) came together for the Fourth Annual CNBP Conference, Tue 28th November to Fri 1st December 2017, in what was a jam-packed schedule of science.

Activities at the Conference included ‘quick speed’ data blitz presentations; key note speeches from CNBP researchers and international guests including from Professor Kishan Dholakia, Professor Kelly Nash and Professor Volker Deckert; science speed dating sessions; poster sessions and team building activities including the infamous grand spaghetti tower challenge which proved to be far more demanding than expected!

The largest Conference to date, the event allowed for an amazing amount of fantastic data to be shared, with collaborations continuing to be built and developed, and new ideas being generated and explored by enthusiastic and engaged team members from across all nodes and partner institutions.

Additional Conference highlights included a professional development session by Dr Peter Grace investigating “The how and why of networking for Scientists” and then a discussion on the importance of tools and social platforms such as LinkedIn, and then pointers on how best to approach senior researchers and potential collaborators at events and other Conferences.

Finally, there was a ‘reflective session’ which provided an opportunity to reflect on science discussions and to then actively plan for the next 12 months of CNBP related activity.

Below – Photos from what was an extremely rewarding Conference!

Copper oxide nanocubes good for bioimaging

Nafisa Zohora4 December 2017:

New CNBP research determines that copper oxide nanocubes are suitable for long-term bioimaging experiments. Lead author on the paper – CNBP PhD student Zafisa Zohora (RMIT University).

Journal: Scientific Reports.

Publication titleFluorescence brightness and photostability of individual copper (I) oxide nanocubes.

Authors: Nafisa Zohora, Ahmad Esmaielzadeh Kandjani, Antony Orth, Hannah M. Brown, Mark R. Hutchinson & Brant C. Gibson.

Abstract:
Conventional organic fluorophores lose their ability to fluoresce after repeated exposure to excitation light due to photobleaching. Therefore, research into emerging bright and photostable nanomaterials has become of great interest for a range of applications such as bio-imaging and tracking. Among these emerging fluorophores, metal oxide-based nanomaterials have attracted significant attention as a potential multifunctional material with photocatalytic and angeogenisis abilities in addition to fluorescnce applications. However, most of these applications are highly dependent on size, morphology, and chemo-physical properties of individual particles. In this manuscript, we present a method to study the intrinsic optical characteristics of individual copper (I) oxide (Cu2O) nanocubes. When excited at 520 nm using only 11 µW excitation power (1.7 W/cm2), individual nanocubes were observed to emit light with peak wavelengths ~760 nm which is conveniently within the near-infrared 1 (NIR1) biological window where tissue autofluorescence is minimal. Bright and photostable fluorescence was observed with intensities up to 487 K counts/s under constant illumination for at least 2 minutes with a brightness approximately four times higher than the autofluorescence from a fixed cumulus-oocyte complex. With near-IR emission, high fluorescence brightness, and outstanding photostability, Cu2O nanocubes are attractive candidates for long-term fluorescent bioimaging applications.