CNBP and Macquarie University PhD candidate Shilun Feng is first author on a new paper exploring a ‘membrane-on-a-chip’ device. The technology has the potential to form an integral part of a new type of microneedle that would be able to transport tiny and precise amounts of fluid/medication within the body.
Publication title: Microfluidic Droplet Extraction by Hydrophilic Membrane.
Authors: Shilun Feng, Micheal N. Nguyen, and David W. Inglis.
Abstract: Droplet-based microfluidics are capable of transporting very small amounts of fluid over long distances. This characteristic may be applied to conventional fluid delivery using needles if droplets can be reliably expelled from a microfluidic channel. In this paper, we demonstrate a system for the extraction of water droplets from an oil-phase in a polymer microfluidic device. A hydrophilic membrane with a strong preference for water over oil is integrated into a droplet microfluidic system and observed to allow the passage of the transported aqueous phase droplets while blocking the continuous phase. The oil breakthrough pressure of the membrane was observed to be 250 ± 20 kPa, a much greater pressure than anywhere within the microfluidic channel, thereby eliminating the possibility that oil will leak from the microchannel, a critical parameter if droplet transport is to be used in needle-based drug delivery.