PLGA nanocomposites developed for PDT of cancer cells

staff photos for Centre of Excellence in Nanoscale Biophotonics (CNBP)24 November 2016:

In this latest paper, CNBP researchers (lead author Wei Deng pictured left) developed PLGA nanocomposites by incorporating a photosensitizer, verteporfin and gold nanoparticles into the polymeric matrix and utilised them for enhanced photodynamic therapy of cancer cells.

Journal: RSC Advances.

Title: PLGA nanocomposites loaded with verteporfin and gold nanoparticles for enhanced photodynamic therapy of cancer cells.

Authors: Wei Deng, Zofia Kautzka, Wenjie Chen and Ewa M Goldys.

Abstract: In this paper, PLGA nanocomposites were developed by incorporating a photosensitizer, verteporfin and gold nanoparticles into the polymeric matrix and utilised for enhanced photodynamic therapy of cancer cells. Both enhanced fluorescence and O2 generation from verteporfin were observed in this new formulation under both 425 nm LED and 405 nm laser illumination. A maximum enhancement factor of 2.5 for fluorescence and 1.84 for O2 generation was obtained when the molar ratio of gold : VP was 5:1 and excited at 425 nm, compared with PLGA doped with verteporfin alone. The experiment results could be explained by the local electric field enhancement of gold nanoparticles. Furthermore, improved therapeutic efficacy in human pancreatic cancer cells, PANC-1, was also demonstrated by using this new formulation following light exposure, indicating the utility of these nanocomposites for enhanced photodynamic therapy.

The paper is accessible online.