Monthly Archives: September 2016

CNBP on Scope TV!

Malcolm Purdey Low Res Edit 007524 September 2016:

Scope TV  takes a look at the latest and greatest in scientific advancements and explores what’s up and coming in the wonderful world of science.

CNBP researcher Dr Malcolm Purdey features in the latest episode of Scope, discussing light based sensing and explaining how innovative optical technologies are opening up exciting new windows into the body.

Click to the 5.20 minute mark to see Malcolm and his science communication in action!

 

USA to Australia Fellowship applications now open

cnbplogosquare123 September 2016:

CNBP and the American Australian Association (AAA) are pleased to announce that applications for the 2017 ‘Centre for Nanoscale BioPhotonics Fellowship’ are now open.

The Fellowship, coordinated by the AAA and funded by the CNBP, provides US$30,000 to support an American PhD or early career Postdoctoral Fellow who wishes to conduct one year of research at a CNBP research node in Australia.

Further information on the CNBP-AAA Fellowship and application details can be found online from the American Australian Association website.

Wide-field optical coherence micro-elastography

rodney-kirk_2_sq_lowrez19 September 2016:

Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins; Wes M. Allen, Lixin Chin, Philip Wijesinghe, Rodney W. Kirk, Bruce Latham, David D. Sampson, Christobel M. Saunders, and Brendan F. Kennedy
Biomedical Optics Express Vol. 7, Issue 10, DOI: 10.1364/BOE.7.004139.

https://www.osapublishing.org/boe/abstract.cfm?uri=boe-7-10-4139

Researchers light-up festival

OLYMPUS DIGITAL CAMERA10 September 2016:

Researchers from the RMIT University node of the Centre for Nanoscale BioPhotonics (CNBP) were out in force to support this year’s AstroLight Festival at Scienceworks, Melbourne, undertaking a wide variety of talks, displays, hands-on activities and demonstrations that entertained and educating over 2000 excited members of the public.

From talks encompassing laser combat in the movies (and how lasers work in real life), to the natural ‘glow-sticks’ found in the living environment, to astronomy at the nanoscale, the CNBP-RMIT team had a blast, in taking their passion for lasers, optics, fluorescence, and all things ‘light-based’ and molecular out to the wider community.

From an evening of highlights, brought together by professional researchers, industry bodies, science communicators and community science groups (and over 250 volunteers), there were amazing wonders of astronomy, light and science to be seen at AstroLight 2016. Not least, a cutting edge fluorescence microscope brought to the event by CNBP that allowed attendees to view the amazing biology that makes up cells, to a scanner that could take 3D images of objects in real-time, to colourful laser based activities that demonstrated just how light waves work.

A/Prof Brant Gibson, CNBP node leader at RMIT University saw the festival as a huge success. “All of the contributors and organisations came together to share their knowledge and expertise and there was plenty of fun and engaging activities for individuals of all ages to participate in.”

Gibson was particularly happy with the way in which the CNBP-RMIT researchers came together to support the event. “They worked tirelessly in producing suitable talks and demonstrations as there was a real desire to showcase our science in the most appealing and engaging way possible. The large numbers of people at our stand and in our CNBP demonstration rooms, all curious about biophotonics, was testament to the effort, energy and enthusiasm shown by our team in making this event so memorable.”

Gibson also commented on the importance of taking science out to the community. “It’s critical that we communicate the fantastic research that we are doing, and that we do it in a way that makes it real and important to the general public and that they can see how it impacts on their everyday lives. Of course, making it fun and exciting as well, is the perfect way to showcase what we do which is why AstroLight is such an outstanding festival.”

Inspiring the next generation of potential researchers was also a key objective to participating. “We really want to encourage an interest in, and continued learning in STEM subjects that will foster future innovation,” said Gibson. “Hopefully some of the children wowed by our lasers and talks will be doing my job in twenty-five years time. Wouldn’t that be great!”

Below – CNBP researcher Emma Wilson demonstrates use of a fluorescence microscope.

OLYMPUS DIGITAL CAMERA

Sensing sound with light

Ivan Maksymov Low Res Edit 01479 September 2016:

New research from CNBP  researcher Ivan Maksymov and CNBP CI Andrew Greentree outlines a new way to detect ultrasound in the body.

The researchers showed that a plasmonic nanoantenna – like a television antenna, but 1000 times smaller than the width of a human hair – can be used to sense ultrasound in the body.

“The biggest problem with sensing ultrasound is the size of the receiver” explains Dr Maksymov. “By using metal nanoparticles, we have shown that we can shrink the size of the hydrophone.” Smaller detectors mean that ultrasound can be probed in smaller areas of the body. “The key is to look inside the smallest blood vessels.”

Solving the work was challenging as the device operates in the so-called deep subwavelength regime – where the size of the device is much smaller than the wavelength of both the light and the sound.

The research appeared in the journal Scientific Reports on the 9th of September, 2016.

Journal: Scientific Reports.

Publication title: Plasmonic nanoantenna hydrophones.

Authors: Ivan S. Maksymov & Andrew D. Greentree.

Abstract: Ultrasound is a valuable biomedical imaging modality and diagnostic tool. Here we theoretically demonstrate that a single dipole plasmonic nanoantenna can be used as an optical hydrophone for MHz-range ultrasound. The nanoantenna is tuned to operate on a high-order plasmon mode, which provides an increased sensitivity to ultrasound in contrast to the usual approach of using the fundamental dipolar plasmon resonance. Plasmonic nanoantenna hydrophones may be useful for ultrasonic imaging of biological cells, cancer tissues or small blood vessels, as well as for Brillouin spectroscopy at the nanoscale.

The paper is available online.

State Government Minister visits CNBP

mark-and-minister8 September 2016:

CNBP was delighted today to have hosted a visit from SA State Government Minister Martin Hamilton-Smith MP, Minister for Investment and Trade, Small Business, Defence Industries and Veteran’s Affairs.

During the visit, the Minister was provided an overview of CNBP biophotonic activity by Director Prof Mark Hutchinson and was taken on a tour of the CNBP laboratories at the University of Adelaide to see CNBP science in action.

In coming weeks, Prof Hutchinson will be accompanying the Minister on a delegation visit to Tokyo hosted by Health Industries SA and will be visiting the Australian Embassy in Tokyo and industry interests in Japan as well.

Hamilton-Smith noted that he was extremely interested in CNBP’s work, particularly in the food industry space in relation to premium quality sensing techniques.

New CNBP laboratory opened at Macquarie University

OLYMPUS DIGITAL CAMERA6 September 2016:

CNBP’s new ‘Biomolecular Discovery Laboratory’, along with two other new laboratories at Macquarie University (a redeveloped Synthetic Biology Lab and new research facilities for Organometallics), were officially opened today by Professor Mary O’Kane, NSW Chief Scientist and Engineer.

The opening event, hosted by Macquarie University’s Deputy Vice-Chancellor (Research), Professor Sakkie Pretorius saw a number of VIP guests in attendance including CNBP Director, Prof Mark Hutchinson.

Hutchinson who spoke at the official opening noted the close collaboration between Macquarie University and the CNBP and explained how the relationship between the two organisations exemplified and gave real meaning to the Centre’s four key belief principles of Academic Excellence, Commercial Impact, Quality Communication and a Nurturing Environment.

The new CNBP laboratory space at Macquarie University will host twenty-four CNBP researchers and will support the development of new biomolecular probes and methodology, the functionalisation of nanoparticles, as well as the investigation of nanoparticle mechanisms and drug delivery.

Additionally, it will facilitate interactions between CNBP chemists, mass spectrometrists, biochemists, physicists and biologists in a large single area, aiding CNBP interdisciplinary research in the development of its new light based sensing tools that operate at the nanoscale.

Below – Professor Mary O’Kane, NSW Chief Scientist and Engineer cuts a ribbon to formally open the laboratory spaces while guests look on.

OLYMPUS DIGITAL CAMERA

Detection of prostate cancer cells

Nima Sayyadi_web5 September 2016:

The latest paper published by CNBP researchers (lead author Nima Sayyadi, pictured left), reports on a bright red water soluble luminescent molecular probe that was successfully synthesized, with multiple platforms developed for sensitive immunodetection of prostate cancer cells. The probe has immediate potential for sensitive detection of a wide range of proteins and disease-specific cellular antigens.

Journal: Analytical Chemistry.

Publication title: Sensitive time-gated immunoluminescence detection of prostate cancer cells using a TEGylated europium ligand.

Authors: Nima Sayyadi, Irene Justiniano, Russell Edwin Connally, Run Zhang, Bingyang Shi, Liisa Kautto, Arun V Everest-Dass, Jingli Yuan, Bradley John Walsh, Dayong Jin, Robert Drant Willows, James A. Piper, and Nicolle H. Packer.

Abstract: We describe the application of a synthetically developed tetradentate β-diketonate-europium chelate with high quan-tum yield (39%), for sensitive immunodetection of prostate cancer cells (DU145). MIL38 antibody, a mouse monoclonal antibody against Glypican 1, conjugated directly to the chelate via lysine residues, resulted in soluble (hydrophilic) and stable immunoconjugates. Indirect labeling of the antibody by a europium chelated secondary polyclonal antibody and a streptavidin/biotin pair was also performed. All of these bright luminescent conjugates were used to stain DU145 cells, a prostate cancer cell line, using time gated luminescence microscopy for imaging, and their performances were compared to conventional FITC labelling. For all prepared conjugates, the europium chelate in conjunction with a gat-ed auto-synchronous luminescence detector (GALD) completely suppressed the cellular autofluorescence background to allow capture of vivid, high contrast images of immune-stained cancer cells.

The paper is available online.

Welcome Akash Bachhuka

OLYMPUS DIGITAL CAMERA2 September 2016:

CNBP would like to welcome Akash Bachhuka, Research Fellow, to the Centre for Nanoscale BioPhotonics for a six-month period.

Akash who has just finished his PhD a few months ago at the University of South Australia, will join CNBP Investigator Prof Heike Ebendorff-Heidepriem’s team at the University of Adelaide.

During his time with CNBP, Akash will work with Centre researchers Roman Kostecki and Sabrina Heng on surface functionalisation.

Welcome aboard Akash!