Singlet oxygen generation in photosensitizers

staff photos for Centre of Excellence in Nanoscale Biophotonics (CNBP)10 August 2016:

Researchers from the CNBP have published a paper reporting on the modification of the efficiency of singlet oxygen generation in photosensitizers conjugated to dielectric (CeF3) and metal (Au) nanoparticles in water.

Journal: Journal of Photochemistry and Photobiology A: Chemistry.

Publication title: Nanoparticle-mediated singlet oxygen generation from photosensitizers.

Authors: Sandhya Clement (pictured above), Mushtaq Sobhan, Wei Deng, Elizabeth Camilleri, Ewa M. Goldys.

Abstract: We report on the modification of the efficiency of singlet oxygen generation in photosensitizers conjugated to dielectric (CeF3) and metal (Au) nanoparticles in water. The conjugates were formed with two photosensitizers, verteporfin and Rose Bengal. Quantitative analysis of the singlet oxygen generation demonstrated that the conjugation of the photosensitizer to a nanoparticle increases the efficiency of the photosensitizers to produce singlet oxygen in water. The singlet oxygen quantum yield of UV-sensitized verteporfin increases by a factor of 1.45 and 1.64 for CeF3-verteporfin and Au-verteporfin conjugates respectively compared to unconjugated verteporfin. Furthermore, Au-Rose Bengal conjugates also demonstrated enhanced singlet oxygen yield when sensitized at the plasmonic wavelength of 532 nm. We quantitatively explain these findings by the electric field enhancements around the nanoparticles.

The paper is available online.