Monthly Archives: July 2016

Cell colour technology shortlisted for Eureka honours


Professor Ewa Goldys, CNBP Deputy Director and Dr Martin Gosnell, Quantitative Pty Ltd, have been selected as finalists in the prestigious Australian Museum Eureka Prizes, for their work in developing technology that enables colour to be used as a uniquely powerful diagnostic tool in medicine.

Selected in the award category ‘2016 ANSTO Eureka Prize for Innovative Use of Technology’, Goldys and Gosnell use modern day microscopes and powerful computer analysis to explore the subtle colour differentiations of cells and tissue, down to a molecular level.

“With our pioneering hyperspectral imaging technique we are able to unveil the biomolecular composition of cells and their nanoscale contents,” said Ewa Goldys, Deputy Director of the ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP) and a Professor at Macquarie University.

“This lets us distinguish between healthy and diseased cells in areas as diverse as embryology, neurodegeneration, cancer and diabetes. Key is the great potential of this technology to impact positively on lives – supporting clinicians in making improved diagnosis and health decisions for patients.”

Noting that it was a pleasure and a privilege to be nominated as a Eureka finalist, Goldys concluded, “Our innovative methodology is letting us probe the very limits of our understanding of life at the molecular level. It’s important that we share these amazing discoveries with the public and the community at large – the Eureka Prizes are the perfect platform to help support us in these efforts.”

Dr Martin Gosnell, CNBP research affiliate and Managing Director at Quantitative Pty Ltd was equally pleased by the Eureka nomination.

“I’m absolutely delighted that our research has been recognised at this level. By using the colour of light from cells and tissues, we are pushing the very frontiers of molecular exploration and measurement.”

“Our high-powered data analysis and imaging expertise is truly opening up new windows into the body.”

The Eureka Prizes are presented by the Australian Museum and reward excellence in research and innovation, science communication and journalism, leadership and school science.

Prize winners will be announced at an Awards Dinner at Sydney Town Hall on Wednesday 31 August 2016.

Third harmonic generation of ECFs

Stephen Warren-Smith28 July 2016:

Researchers from CNBP and The Institute of Photonic Technology (IPHT), have had a paper published today on the topic of third harmonic light generation using ECFs.

Journal: Optics Express.

Publication title: Third harmonic generation in exposed-core microstructured optical fibers.

Authors: Stephen C. Warren-Smith, Jingxuan Wie, Mario Chemnitz, Roman Kostecki, Heike Ebendorff-Heidepriem, Tanya M. Monro and Markus A. Schmidt.

Inter-modal phase-matched third harmonic generation has been demonstrated in an
exposed-core microstructured optical fiber. Our fiber, with a partially open core having a
diameter of just 1.85 µm, shows efficient multi-peak third-harmonic generation between 500nm and 530 nm, with a maximum visible-wavelength output of 0.96 μW. Mode images and simulations show strong agreement, confirming the phase-matching process and polarization dependence. We anticipate this work will lead to tailorable and tunable visible light sources by exploiting the open access to the optical fiber core, such as depositing thin-film coatings in order to shift the phase matching conditions.

The paper is available online.

In vivo measurements of brain temperature

Stefan_Musolino_sq_web20 July 2016:

CNBP researcher  Stefan Musolino is lead author on a new paper reporting on the development of an optical fiber based probe for in vivo measurements of brain temperature.

Journal: Biomedical Optics Express

Publication title: Portable optical fiber probe for in vivo brain temperature measurements.

Authors: Stefan Musolino, Erik P. Schartner, Georgios Tsiminis, Abdallah Salem, Tanya M. Monro, and Mark R. Hutchinson.

This work reports on the development of an optical fiber based probe for in vivo measurements of brain temperature. By utilizing a thin layer of rare-earth doped tellurite glass on the tip of a conventional silica optical fiber a robust probe, suitable for long-term in vivo measurements of temperature can be fabricated. This probe can be interrogated using a portable optical measurement setup, allowing for measurements to be performed outside of standard optical laboratories.

The paper is accessible online.

Tiny gemstones advance nanoscale imaging

Low Res Edit 010620 July 2016:

A research team at the ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP) – led by Dr Philipp Reineck (pictured) from RMIT University’s School of Science – tested ruby and diamond particles, more than a thousand times smaller than the diameter of a hair, alongside other nanoparticles for use in biological imaging, and found that they have a higher degree of stability, critical to achieving imaging success. You can read more about it in the online publication ‘Science meets Business’.