Monthly Archives: May 2016

Light-emitting nanoparticles embedded into glass

Tim Zhao_sq30 May 2016:

Dr Tim Zhao, CNBP Associate Investigator (University of Adelaide) is lead author on a new research paper, reporting on an innovative method for embedding light-emitting nanoparticles into glass without losing any of their unique properties. The paper’s results made the University of Adelaide news site!

Publication Title: Upconversion Nanocrystal-Doped Glass: A New Paradigm for Photonic Materials.

Authors: Jiangbo Zhao, Xianlin Zheng, Erik P Schartner, Paul Ionescu, Run Zhang, Tich-Lam Nguyen, Dayong Jin and Heike Ebendorff-Heidepriem.

Abstract: The integration of novel luminescent nanomaterials into glassy matrix can lead to new hybrid materials and photonic devices with promising material performance and device functions. Lanthanide-containing upconversion nanocrystals have become unique candidates for sensing, bioimaging, photon energy management, volumetric displays, and other photonic applications. Here, a versatile direct-doping approach is developed to integrate bright upconversion nanocrystals in tellurite glass with tailored nanoscale properties. Following our two-temperature glass-melting technique, the doping tempera-
ture window of 550–625 °C and a 5 min dwell time at 577 °C are determined as the key to success, which balances the survival and dispersion of upconversion nanocrystals in glass. It is identified that the fine spectra of upconversion emissions can be used to diagnose the survival and dissolution fraction of doped nanocrystals in the glass. Moreover, 3D dispersion of nanocrystals in the glass is visualized by upconversion scanning confocal microscopy. It is further demonstrated that a low-loss fiber, drawn from the highly transparent nanocrystals-doped glass retains the distinct optical properties of upconversion nanocrystals. These results suggest a robust strategy for fabrication of high-quality upconversion nanocrystal-doped glasses. The new class of hybrid glasses allows for fiber-based devices to be developed for photonic applications or as a useful tool for tailoring light–nanoparticles interactions study.

The paper is available online.

UHN Toronto partnership launch

UHN Launch_sq30 May 2016:

The CNBP has officially launched an international research partnership with the University Health Network (Toronto) following a successful event, undertaken at the Princess Margaret Cancer Centre on the 30th May 2016.

The partnership broadens the potential for research collaboration between the CNBP and the UHN as well as strengthens the current links and ties that already exist between the two organisations.

According to CNBP Director, Prof Mark Hutchinson, highlights from the day included an all day science workshop featuring plenty of opportunities for brainstorming between the teams researchers, as well as the  identification of immediate opportunities for materials and sample sharing.

“Formalizing the partnership between the CNBP and the UHN makes perfect sense and will provide both organisations with improved opportunities and expertise in the undertaking of leading edge biophotonics research”, said Hutchinson.

Below, the formal handover of the CNBP partner plaque by CNBP Director Prof Mark Hutchinson (far right) to UHN’s Prof Brian Wilson (second right). 

UHN Launch

Director speaks at CAN-ACN

Mark Hutchinson Low Res Edit 016429 May 2016:

Prof Mark Hutchinson (CNBP Director) has given an invited talk about glial cells and pain in a satellite symposium run by The Canadian Neurophotonics Platform at the 10th Annual Canadian Neuroscience Meeting, May 29th, 2016, Toronto.

Mark’s talk was titled, “The Toll of Knowing you are sick: Implications for pain and addiction.”

The day long symposium featured a number of speakers focused on the use of light-based tools to help decipher the functional neural map of the human brain.



CNBP visits Singapore, Sweden and Denmark

Malcolm Purdey Low Res Edit 007527 May 2016:

Research Associate Malcolm Purdey has presented a science poster at the Biosensors Conference in Gothenburg, Sweden (May 27th 2016). The poster was titled, “Optical fibre probes for hydrogen peroxide and pH in reproductive health.”

He has also given CNBP focused talks at the University of Lund, University of Copenhagen (Denmark), and Nanyang Polytechnic (Singapore).

Malcolm’s first talk at Nanyang Polytechnic in Singapore was given to a group of first year students (several students reaching their final year at the Polytechnic have gone on to undertake 3-month placements with the CNBP “Recognise” team in Adelaide).

Malcolm also met with Prof. Katarina Svanberg (from the CNBP International Scientific Committee) at Lund University and gave a presentation to the Medical Laser Centre group in the Department of Physics.

Following this, he also met with some collaborators at the University of Copenhagen, and gave a presentation in the Department of Chemistry.

Malcolm’s talks were titled: “Fluorescent Sensors for BioPhotonics.”

US Defence delegation visits Centre

US-Defence-Delegation-at-MQ-labs_2_web26 May 2016:

Representatives from US Defense Force science and research offices were today hosted by CNBP researchers at  Macquarie University.

The visit, organised by the Australian National Fabrication Facility (ANFF), included informal talks as well as visits to CNBP’s biology, biophotonics, optics and materials laboratories.

The laboratory visits gave CNBP researchers the opportunity to showcase their work with an overview of CNBP activity and research direction also provided. Discussed were potential synergies and areas of collaboration.

Below, CNBP Associate Investigator Dr Alf Garcia-Bennett discusses his work on protein corona formation on nanoparticles.


Heike Ebendorff-Heidepriem gives seminar at USYD

Heike Ebendorff Low Res Edit 018025 May 2016:

CNBP Investigator, Professor Heike Ebendorff-Heidepriem has presented a seminar at the Institute of Photonics and Optical Science at the University of Sydney on 25 May 2016.

Heike’s talk title was: Taming the Light in Optical Fibres for Sensing.

Abstract – This talk reviews the light-based sensing approaches developed at the Institute for Photonics and Advanced Sensing (IPAS) at Adelaide University in the field of chemical and physical sensing utilizing novel light sources and optical fibres. Depending on the intended application, a host of sensing modalities have been utilized including labelled fluorescence techniques, and label-free methods such as spectroscopy, surface plasmon resonance, fiber Bragg gratings, and Raman scattering. The use of various functionalization techniques adds specificity to ions and molecules. Microstructured and hybrid material optical fibers offer important benefits compared to traditional techniques such as small sample volumes, high sensitivity, remote sensing and multiplexing.

New Research Fellow role for Nima Sayyadi

Nima Sayyadi_web25 May 2016:

Dr. Nima Sayyadi at Macquarie University, former CNBP Associate Investigator, has been employed as a CNBP Research Fellow.

Dr Sayyadi  has previously been responsible for designing  and developing a series of novel europium luminescent chelates which have successfully been applied to the detection of Staphylococcus aureus using luminescent in situ hybridization (LISH) techniques. He has also developed europium chelates using different immunoconjugate platforms for sensitive TGL detection of a wide range of bacteria, protozoa and human cancer cells.

His new CNBP related activity will involve exploring the synthesis and application of novel lanthanide chelates for the sensitive time-gated luminescence (TGL) detection of bio-targets in complex biological matrices.

More specifically Dr Sayyadi’s activity will be focused on the following –

* Synthesis of Europium chelate molecules with different conjugation functionality e.g. amino, sulphydryl, alkyne, hydrazide.

* Conjugation of Europium chelates to protein, sugars, nucleic acids, and characterization of the conjugates.

* Testing and application of time-gated orthogonal scanning automated microscopy (OSAM) and standing microscope (when developed) for single cell detection of Europium chelates

* Time-gated luminescent immunodetection (using IgG and IgM) for detection of target proteins in biological samples (urine, blood, and saliva).

Well done on the gaining of your new role Nima!

CNBP at US-Australia Technical Exchange meeting

Heike Ebendorff Low Res Edit 018023 May 2016:

Professor Heike Ebendorff-Heidepriem (CNBP Investigator), Dr Lindsay Parker (CNBP Research Fellow) and Dr Andrew Care (CNBP Research Fellow) spoke at the US-Australia Enabling Technologies Technical Exchange Meeting 2016 at UNSW in Sydney on 23-24 May 2016.

Heike’s talk was: “Pushing the Limits in Glass Properties and Structures for Laser, Sensing and Nonlinearity Applications.”

Lindsay’s talk was: “Illuminating mRNA and proteins in new ways with nanoparticles and chemical conjugates.”

Andrew’s talk was: “Developing a platform technology for the self-assembly of functional nanoparticles.”

The purpose of the Technical Exchange is to explore and potentially develop new areas of basic research collaboration between Australian and US participants.

Additional meeting information is available online.


Director speaks at AVA Conference

Mark Hutchinson Low Res Edit 016423 May 2016:

The Director of CNBP, Professor Mark Hutchinson, has undertaken an invited talk at the Australian Veterinary Association (AVA) 2016 Annual Conference held at the Adelaide Convention Centre, Adelaide, from 22-27 May 2016.

Mark’s talk was presented on 23 May 2016 and titled “The ‘toll’ of knowing your are sick: implications for acute pain management and consequences for chronic agony.”