CNBP senior researcher Melanie McDowall (pictured) and CNBP Chief Investigator Jeremy Thompson are co-authors on a newly published paper in the Journal ‘Human Reproduction’.
Publication title: Extending prematuration with cAMP modulators enhances the cumulus contribution to oocyte antioxidant defence and oocyte quality via gap junctions.
Authors: H K Li, M L Sutton-McDowall, X Wag, S Sugimura, J G Thompson and R G Gilchrist.
Can bovine oocyte antioxidant defence and oocyte quality be improved by extending the duration of pre-in vitro maturation (IVM) with cyclic adenosine mono-phosphate (cAMP) modulators?
Lengthening the duration of cAMP-modulated pre-IVM elevates intra-oocyte reduced glutathione (GSH) content and reduces hydrogen peroxide (H2O2) via increased cumulus cell-oocyte gap-junctional communication (GJC), associated with an improvement in subsequent embryo development and quality.
The paper is available online.