Extending prematuration with cAMP modulators enhances oocytes

Mel McDowall High Res Edit 004022 February 2016:

CNBP senior researcher Melanie McDowall (pictured) and CNBP Chief Investigator Jeremy Thompson are co-authors on a newly published paper in the Journal ‘Human Reproduction’.

Publication title: Extending prematuration with cAMP modulators enhances the cumulus contribution to oocyte antioxidant defence and oocyte quality via gap junctions.

Authors: H K Li, M L Sutton-McDowall, X Wag, S Sugimura, J G Thompson and R G Gilchrist.

Abstract:

STUDY QUESTION:

Can bovine oocyte antioxidant defence and oocyte quality be improved by extending the duration of pre-in vitro maturation (IVM) with cyclic adenosine mono-phosphate (cAMP) modulators?

SUMMARY ANSWER:

Lengthening the duration of cAMP-modulated pre-IVM elevates intra-oocyte reduced glutathione (GSH) content and reduces hydrogen peroxide (H2O2) via increased cumulus cell-oocyte gap-junctional communication (GJC), associated with an improvement in subsequent embryo development and quality.

The paper is available online.