Cytokine detection based on immunosensing

guozhen_liu8 January 2016:

CNBP researchers Guozhen Liu, Mark Hutchinson and Ewa Goldys are all authors on a recent review paper examining the detection of cytokines  based on immunosensing. The paper was published in the journal Biosensors and Bioelectronics.

Paper Title:  “Recent advances in cytokine detection by immunosensing.”

Abstract: The detection of cytokines in body fluids, cells, tissues and organisms continues to attract considerable attention due to the importance of these key cell signaling molecules in biology and medicine. In this review, we describe recent advances in cytokine detection in the course of ongoing pursuit of new analytical approaches for these trace analytes with specific focus on immunosensing.

We discuss recent elegant designs of sensing interface with improved performance with respect to sensitivity, selectivity, stability, simplicity, and the absence of sample matrix effects. Various immunosensing approaches based on multifunctional nanomaterials open novel opportunities for ultrasensitive detection of cytokines in body fluids in vitro and in vivo.

Methodologies such as suspension arrays also known as bead assays together with optical fiber-based sensors, on their own or in combination with microfluidic devices will continue to have an important role to address the grand challenge of real-time in vivo multiplex cytokine detection.

The paper is available online.