Monthly Archives: October 2015

Coverage: Chronic pain may be about rewiring the brain

Mark Hutchinson Low Res Edit 016412 October 2015:

CNBP Director Mark Hutchinson is interviewed about chronic pain in this article in the Huffington Post.

He explains the differences between acute and chronic pain and notes the need for new approaches – the challenge is to work with a patient to “change that person’s brain so that they are able to feel pain differently.”

Says Hutchinson, “We’ve had to rethink pain and Australia has been at the forefront.”

 

 

 

 

Business Insider panel discussion

Ewa Goldys Low Res Edit 015912 October 2015:

Molecular analysis, big data, the smart economy, commercialisation and Star Trek style advances in medical technology were just some of the topics covered by Centre Deputy Director, Ewa Goldys, as a panelist at today’s ‘Business Insider’ event.

Goldys joined Sean Hogan (IBM), Patrick Brennan (the University of Sydney) and David Hansen (CSIRO) in talking about the convergence of technology and medicine, on a panel discussion that took place as part of Business Insider’s ‘Smarter Health Partner Series’.

The well attended event saw a moderated panel style format, networking opportunities as well as significant informal discussion. Key themes included technology and collaboration, increasing use of super computing and big data, and recent developments in preventative health and early management of disease.

Image: L Ewa Goldys. R Sean Hogan.

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Dr Jingxian Yu speaks at ISE 2015

Jingxian Yu8 October 2015:

Dr Jingxian Yu, CNBP researcher, has given an oral presentation at ISE 2015, the 66th Annual Meeting of The International Society of Electrochemistry, held on 4-9 October 2015, in Taipei, Taiwan.

The title of the presentation was: “Tunable Peptide-Based Molecular Wires: Experimental Evidence and Theoretical Insights.”

The ISE meeting is organised annually and is attended by more than 1,200 scientists and engineers from around the globe.

At the meeting, Dr Yu was invited by the Guest Editor for Symposium 11, Professor Flavio Maran, to submit a contribution for the upcoming Special Issue of Electrochimica Acta (Impact factor = 4.5). Submission to the special issue is based on invitation only.

New CNBP PhD student at MQ Uni

Felix_web7 October 2015:

The Macquarie University node of CNBP is growing rapidly!

Last week we were delighted to welcome a new PhD student Fei Wang (Felix) who is supported by a CSC scholarship.

Felix will be working with Professor Ewa Goldys and Doctors Wei Deng (DECRA Fellow at MQ) and Guozhen Liu (CNBP) as well as with Professor Alexander Engel, colorectal surgeon at the Royal North Shore Hospital and Director of Sydney Vital.

The project will be focused on the development of molecularly targeted nanoparticle-based medical diagnostics.

Image L to R – Wei Deng, Fei Wang and Guozhen Liu.

RMIT node leader visits Macquarie Uni

brantgibson6 October 2015:

Brant Gibson, CNBP node leader at RMIT, visited Macquarie University for two days on October 6/7 and gave an invited colloquium in the Physics department and also had a number of meetings with CNBP personnel.

The well attended colloquium was titled, “Nanodiamond: BioPhotonic and Hybrid-Photonic Applications,” and examined ways in which nano-diamonds are ideal  for developing fluorescent bioimaging nanoprobes. Details of the research activities at the RMIT node of the ARC Centre of Excellence for Nanoscale BioPhotonics were also discussed.

Brant-at-MQ-web

 

Bio-conjugation of protein molecules to upconversion nanoparticles

Dayong Jin  Low Res Edit 00962 October 2015:

A novel, simple, and stable method for one-step bio-conjugation of protein molecules to upconversion nanoparticles is demonstrated in the latest paper released by CNBP researchers in the journal ‘Analytical Chemistry’.

The paper is titled “One-step Protein Conjugation to Upconversion Nanoparticles.”

Authors: Jie Lu, Yinghui Chen, Deming Liu, Wei Ren, Yiqing Lu, Yu Shi, James A. Piper, Ian T. Paulsen, and Dayong Jin.

The full paper is available online with the abstract included below.

Abstract: The emerging upconversion nanoparticles offer a fascinating library of ultrasensitive luminescent probes for a range of biotechnology applications from biomarker discovery, single molecule tracking, early disease diagnosis, deep tissue imaging, to drug delivery and therapies.

The effective bio-conjugation of inorganic nanoparticles to the molecule-specific proteins, free of agglomeration, non-specific binding or biomolecule de-activation, is crucial for molecular recognition of target molecules or cells.

The current available protocols require multiple steps which can lead to low probe stability, specificity and reproducibility. Here we report a simple and rapid protein bio-conjugation method based on a one-step ligand exchange using the DNAs as the linker. Our method benefits from the robust DNA-Protein conjugates as well as from multiple ions binding capability.

Protein can be pre-conjugated via an amino group at the 3’ end of a synthetic DNA molecule to the protein, so that the 5′ end phosphoric acid group and multiple phosphate oxygen atoms in the phosphodiester bonds are exposed to replace the oleic acid ligands on the surface of upconversion nanoparticles due to their stronger ions-chelating capability to lanthanides.

We demonstrated our method can efficiently pull out the upconversion nanoparticles from organic solvent into an aqueous phase. The upconversion nanoparticles then become hydrophilic, stable and specific biomolecules recognition. This allows us to successfully functionalize the upconversion nanoparticles with horseradish peroxidise (HRP) for catalytic colorimetric assay and for streptavidin (SA) biotin affinity assays.

 

Collaborating with CSIRO

CSIRO launch1 October 2015:

CNBP officially launched its partnership with CSIRO today, at an on-site event at the Clayton facility of CSIRO in Melbourne, Victoria, Australia.

Partner, Professor Yonggang Zhu, Team Leader of CSIRO’s Microfluidic Platforms Team, announced that he was extremely privileged to be a partner of CNBP and looks forward to future collaborations.

Centre Director, Professor Mark Hutchinson acknowledged CSIRO’s contribution to CNBP and indicated new areas of potential collaboration, which would include the Centre’s Spark of Life theme and embryological research.

The launch consisted of a number of science presentations from CSIRO researchers, together with researchers from Monash University. Industry representatives included Trajan Scientific Australia Pty Ltd and the Australian National Fabrication Facility.

CNBP colleagues from all three research nodes of CNBP – Macquarie University, RMIT University and the University of Adelaide, were present at the launch and science discussions were presented by Prof Dayong Jin, UTS; Prof Ewa Goldys, Centre Deputy Director, Macquarie University; Researcher, Dr Philipp Reineck, RMIT University; Researcher, Dr Ivan Maksymov, RMIT University; and Professor Andrew Abell, Chief Investigator and Node Director, University of Adelaide.

Lab tours were conducted at CSIRO, along with many group discussions, engaging CNBP and CSIRO researchers alike. At the conclusion of launch proceedings, CSIRO was presented with a formal CNBP partner plaque.

CNBP is continuing to deliver transdisciplinary conversations with our partners and looks forward to the current and future benefits of this valuable partnership with CSIRO.