Monthly Archives: October 2015

New CNBP student at MQ

Meng-He28 October 2015:

CNBP’s Macquarie University node welcomes its newest PhD student, Meng He.

Meng holds a Masters degree of Science, with a major in Biochemistry and Molecular Biology, having graduated from Fujian Normal University, China in June 2015. His thesis focused on bistratal artificial blood vessels and issues of bio-compatibility.

Meng will be supervised by Prof. Ewa. Goldys (CNBP Deputy Director)  and Prof. Roger Chung (Australian School of Advanced Medicine) with his research topic still to be fully confirmed.

Welcome to the team Meng He!

 

City University London launch

CUL-launch_web23 October 2015:

CNBP and City University London (CUL) have formally celebrated their ongoing partnership activity, with a successful partner launch and joint workshop, undertaken at City University London, October 23rd, 2015.

As part of proceedings, CNBP Director, Professor Mark Hutchinson, gave a comprehensive review of current CNBP activities, explaining its core themes – illuminate, recognize, measure and discover – and discussed the Centre’s recent research into complex neuronal systems.

This was followed by a series of presentations given by Professor Tong Sun, Professor Azizur Rahman and Dr Arti Agrawal from the Research Centre of Photonics & Instrumentation and by Professor Panicos Kyriacou from the Research Centre of Biomedical Engineering.

Both parties look forward to ongoing collaborations, with CNBP scientists likely to visit CUL again shortly.

Image below: CNBP Director Prof Mark Hutchinson presents a CNBP Partner Plaque to Prof Tong Sun, Director Research Centre of Photonics & Instrumentation, City University London.

CUL launch 2

CNBP does Melbourne Knowledge Week

cnbplogosquare120 October 2015:

CNBP’s RMIT node reached out to the public today, hosting a panel discussion on nanoscale technology as a part of  Melbourne Knowledge Week.

‘Up Close and Revealed: Life at the Nanoscale’ was the theme of the event with a focus on nanoscale optical sensors, quantum technology and next generation computational devices.

Panel speakers consisted of CNBP’s RMIT node leader A/Prof Brant Gibson, CNBP Advisory Board member Prof Goran Roos, Prof Calum Drummond from RMIT and CNBP industry partner Mr Jian Shen from Olympus Australia.

Following the entertaining and informative panel dialogue, members of the public were provided with tours of CNBP’s new research laboratories, and provided with further information on CNBP’s current research activities.

Melbourne Knowledge Week showcases the city’s broad range of innovative projects, institutions and ideas with over 50 separate events taking place from the 19th to 25th October 2015.

Knowledge-Week-RMITab

CNBP researchers visit Wuhan

Wuhan12 October 2015:

CNBP researchers from the University of Adelaide, Dr Jingxian Yu and Dr John Horsley, were invited by several academic facilities in Wuhan, China, to disseminate their recent research.

Lectures were given to the School of Chemistry and Chemical Engineering at Huazhong University of Science and Technology (HUST), China University of Geosciences (CUG), and Central China Normal University (CCNU).

A number of ‘flyers’ were circulated defining the role of the CNBP, in the hope of inspiring bright, enthusiastic students and academics alike to consider a move to Australia.

Whilst in Wuhan, they also had the opportunity and pleasure of visiting CNBP partner, Wuhan National Laboratory for Optoelectronics (HUST), and the Key Laboratory of Biomedical Polymers of the Ministry of Education, at Wuhan University.

Networking provided a number of possible future collaborations, including electron transport in single molecules, with Professors Shan Jin and Shenghua Liu (CCNU), and peptide-based nanocarriers for drug delivery, with Prof Xianzheng Zhang (Wuhan University).

 

Coverage: Chronic pain may be about rewiring the brain

Mark Hutchinson Low Res Edit 016412 October 2015:

CNBP Director Mark Hutchinson is interviewed about chronic pain in this article in the Huffington Post.

He explains the differences between acute and chronic pain and notes the need for new approaches – the challenge is to work with a patient to “change that person’s brain so that they are able to feel pain differently.”

Says Hutchinson, “We’ve had to rethink pain and Australia has been at the forefront.”

 

 

 

 

Business Insider panel discussion

Ewa Goldys Low Res Edit 015912 October 2015:

Molecular analysis, big data, the smart economy, commercialisation and Star Trek style advances in medical technology were just some of the topics covered by Centre Deputy Director, Ewa Goldys, as a panelist at today’s ‘Business Insider’ event.

Goldys joined Sean Hogan (IBM), Patrick Brennan (the University of Sydney) and David Hansen (CSIRO) in talking about the convergence of technology and medicine, on a panel discussion that took place as part of Business Insider’s ‘Smarter Health Partner Series’.

The well attended event saw a moderated panel style format, networking opportunities as well as significant informal discussion. Key themes included technology and collaboration, increasing use of super computing and big data, and recent developments in preventative health and early management of disease.

Image: L Ewa Goldys. R Sean Hogan.

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New CNBP PhD student at MQ Uni

Felix_web7 October 2015:

The Macquarie University node of CNBP is growing rapidly!

Last week we were delighted to welcome a new PhD student Fei Wang (Felix) who is supported by a CSC scholarship.

Felix will be working with Professor Ewa Goldys and Doctors Wei Deng (DECRA Fellow at MQ) and Guozhen Liu (CNBP) as well as with Professor Alexander Engel, colorectal surgeon at the Royal North Shore Hospital and Director of Sydney Vital.

The project will be focused on the development of molecularly targeted nanoparticle-based medical diagnostics.

Image L to R – Wei Deng, Fei Wang and Guozhen Liu.

Bio-conjugation of protein molecules to upconversion nanoparticles

Dayong Jin  Low Res Edit 00962 October 2015:

A novel, simple, and stable method for one-step bio-conjugation of protein molecules to upconversion nanoparticles is demonstrated in the latest paper released by CNBP researchers in the journal ‘Analytical Chemistry’.

The paper is titled “One-step Protein Conjugation to Upconversion Nanoparticles.”

Authors: Jie Lu, Yinghui Chen, Deming Liu, Wei Ren, Yiqing Lu, Yu Shi, James A. Piper, Ian T. Paulsen, and Dayong Jin.

The full paper is available online with the abstract included below.

Abstract: The emerging upconversion nanoparticles offer a fascinating library of ultrasensitive luminescent probes for a range of biotechnology applications from biomarker discovery, single molecule tracking, early disease diagnosis, deep tissue imaging, to drug delivery and therapies.

The effective bio-conjugation of inorganic nanoparticles to the molecule-specific proteins, free of agglomeration, non-specific binding or biomolecule de-activation, is crucial for molecular recognition of target molecules or cells.

The current available protocols require multiple steps which can lead to low probe stability, specificity and reproducibility. Here we report a simple and rapid protein bio-conjugation method based on a one-step ligand exchange using the DNAs as the linker. Our method benefits from the robust DNA-Protein conjugates as well as from multiple ions binding capability.

Protein can be pre-conjugated via an amino group at the 3’ end of a synthetic DNA molecule to the protein, so that the 5′ end phosphoric acid group and multiple phosphate oxygen atoms in the phosphodiester bonds are exposed to replace the oleic acid ligands on the surface of upconversion nanoparticles due to their stronger ions-chelating capability to lanthanides.

We demonstrated our method can efficiently pull out the upconversion nanoparticles from organic solvent into an aqueous phase. The upconversion nanoparticles then become hydrophilic, stable and specific biomolecules recognition. This allows us to successfully functionalize the upconversion nanoparticles with horseradish peroxidise (HRP) for catalytic colorimetric assay and for streptavidin (SA) biotin affinity assays.