Monthly Archives: November 2014

Frontier Technologies for Nervous System Function and Repair

Sanam Mustafa High Res Edit 016630 November 2014: Invited Presentation

CNBP researcher Dr Sanam Mustafa was an  invited speaker at the Mount Lofty workshop. Her talk, “Nanoscale Biophotonics: A multidisciplinary approach to future proofing drug discovery” highlighted opportunities for developing high-throughput, cost-effective technologies for drug discovery.

On 28th-30th November, the Mt Lofty Workshop on Frontier Technologies for Nervous System Function and Repair was hosted at Mt Lofty House in the beautiful Adelaide Hills. The workshop was composed of three sessions: Neural Technologies, Neuroprotection and Neurorepair and Nanoscale Biophotonics. The program included national and international speakers that cover a broad range of topics.

Nanoscale BioPhotonics session at the Mount Lofty Workshop

cnbplogosquare130 November 2014 : Engaging with other researchers

On 28th-30th November, the Mt Lofty Workshop on Frontier Technologies for Nervous System Function and Repair was hosted at Mt Lofty House in the beautiful Adelaide Hills. The workshop included three sessions: (1) Neural Technologies (2)  Neuroprotection and Neurorepair and (3) Nanoscale Biophotonics.

With a program than included national and international speakers, the Nanoscale BioPhotonics session highlighted the transdisciplinary approach CNBP is adopting to answer novel biological questions.

This workshop is considered a boutique and exciting meeting. The meeting had diverse speakers and engaging discussions.

CNBP Resarchers at ACNR workshop

Stefan Musolino Low Res Edit 007330 November  2014 – Optical Fibre in vivo

Dr Erik Shartner and Stefan Mussolino (pictured left) gave an invited presentation at the Adelaide Centre for Neuroscience Research (ACNR) workshop.

Their presentation discussed:

  • the progress that has been made on the development of optical sensors for the measurement of physical and chemical parameters for biomedical applications;
  • transfer of tools developed in an optics lab to real world applications for biologically relevant questions, potentially seeding development of tools which could find further use in other laboratory environments or commercial applications; and
  • establishment of  new forms of assay measurement, and follow these through with in-vivo measurements to study key problems associated with brain functions.

Encouraging future scientists

November 2Neuro014: High School Work Experience

Mr Julian Greentree spent a week in the neuroimmunopharmacology laboratory working with CNBP researchers Ms Vicky Staikopoulos and Dr Sanam Mustafa.

During this time Julian was trained in cell culture techniques and novel clearing histological techniques in the development phases for later rollout in biophotonics projects.

Large scale production of biocompatible nano-alumina

407 December 2014: Manuscript  accepted in Langmuir

Large-scale production and characterisation of biocompatible colloidal nano-alumina

Wan Aizuddin bin W Razali , Varun K. A. Sreenivasan , Ewa M. Goldys , and Andrei V Zvyagin

Abstract: Rapid uptake of nanomaterials in Life Sciences calls for the development of universal, high-yield techniques for their production and interfacing with biomolecules. Top-down methods take advantage of the existing variety of bulk and thin film solid-state materials for improved prediction and control of the resultant nanomaterial properties. We demonstrate the power of this approach using high-energy ball milling (HEBM) of alumina (Al2O3). Nano-alumina particles of the mean size 25 nm in its most stable α-crystallographic phase were produced in gram quantities, suitable for biological and biomedical applications. Nanomaterial contamination from zirconia balls used in HEBM was reduced from 19% to 2% using a selective acid etching procedure. The biocompatibility of the milled nanomaterial was demonstrated by forming stable colloids in water and physiological buffers, corroborated by zeta potentials of +40 mV and -40 mV, and characterized by in vitro cytotoxicity assays. Finally, the feasibility of milled nano-alumina surface to anchor a host of functional groups and biomolecules was demonstrated by functionalisation of their surface using a facile silane chemistry, resulting in decoration of the nanoparticle surface with amino groups suitable for further conjugation of biomolecules.

The full article is available from the Lanmuir website

Social Media report from the CNBP Launch and Retreat

#CNBPNovember 2014: Find out what really happened at the CNBP Retreat

Thanks to Dr Mel McDowall we have a social media report from the CNBP Annual Retreat.

 

Friday 21 November – CNBP Launch and Retreat Welcome Reception

Saturday November 22nd – Day 1 of the retreat – Science and Social Activities

Sunday November 23rd – Day 2 of the retreat – Science and Professional Development

Monday November 24th – Day 3 of the retreat – Science and Wrap-Up

 

Joint International Grant with CNBP Partner UHN

Prof Ewa Goldys26 November 2014: $100,000 grant for University Health Network (Toronto) and CNBP

We are delighted to announce a new chapter in CNBP relationship with our Partner Organisation, the University Health Network (Toronto) with the award of new joint funding by an overseas agency Pancreatic Cancer Canada.

The project entitled “Synchronous radiotherapy enhancement of pancreatic cancer with X- ray induced photodynamic therapy and oxygen generating nanoparticles” will support joint work of Dr Ralph Da Costa, Professor Shirley X.Y. Wu (both from the University Health Network (Toronto) and Professor Ewa Goldys (CNBP CI). The award is worth $ 100,000 for two years.

Pancreatic cancer has the highest mortality rate of all major cancers. The average life expectancy after diagnosis is just three to six months. Surgical removal of the tumor is possible in less than 20% of patients diagnosed the disease.

The new technology developed in this project will expand the repertoire of treatment options for pancreatic cancer.

CNBP visits Port Lincoln High School

High Res Edit 027825 November 2014: Engaging with regional highs school students

A small team of CNBP researcher (A/Prof Andrew Greentree; Dr  Arun Dass, Ms Vicky Staikopoulos and Dr Kathy Nicholson met with over 100 Year 8 and 9 students at Port Lincoln High School to talk about Nanoscale BioPhotonics, Careers in science, and an exploration of physics, and the way that air can lead to surprising results.  In this image we see the use of pressure difference for levitation of a ball.

The Port Lincoln Times ran an article about this activity