13 October 2018:
Dr Arun Everest-Dass, CNBP researcher at the Institute for Glycomics at Griffith University has been interviewed by Nine News about his glycan focused cancer research.
The interview took place during the Institution’s annual Glycomics Week activities, the aim of which is to draw attention to the significant glycan research taking place in the world of infectious disease, cancer and vaccine and drug discovery.
“It was a good opportunity to communicate our science to the wider community,” said Dr Everest-Dass.
“I explained to the news team our exciting new techniques and imaging technologies to help detect and analyse ovarian cancer. This is a key research area as ovarian cancer is the sixth most common cancer affecting Australian women.”
A clip of the interview can be found on the Nine News Twitter channel here.
11 October 2018:
CNBP science and it’s translation into exciting new commercial ventures was on show at the ‘Science meets Business’ event held in Brisbane, October 11th, 2018.
The event, coordinated by STA, brought national and international corporate leaders and entrepreneurs, venture capitalists and angel investors together with Australian research and commercialisation pioneers, to help advance activity in the science and translation space.
First CNBP’er to present at the event was Chief Investigator Prof Jeremy Thompson who shared his amazing startup story in establishing the business ‘ART Lab Solutions’. The venture uses advanced reproductive technologies to accelerate the improvement of livestock quality.
Next up was the CNBP inspired start-up ‘MEQ Probe‘. Featuring presenters CNBP Director Prof Mark Hutchinson, Jordy Kitschke (CEO of MEQ Probe) and Susan McDonald (Managing Director of Super Butcher), all three discussed elements of the innovative start-up that offers industry an advanced spectral analysis tool that can objectively measure the quality of meat.
“MEQ is a story of success for the CNBP in bringing science together with business to solve a multi-billion dollar problem of objective meat quality measurement and assessment,” said Prof Hutchinson. “At CNBP we have made a conscious decision to actively solve real-world pain points, and engage entrepreneurs to turn amazing research into companies, of which MEQ Probe is an excellent example.”
A/Prof. Daniel Kolarich, CNBP Chief Investigator at Griffith University who also attended the event noted that, “Science meets Business impressively showed that translation does not necessarily correlate with the initial intention of the innovation – that the sky really is the limit when it comes to maximising return from research.”
Below: Smiles from the MEQ Probe team having completed their case study to an active and interested audience at ‘Science meets Business’.
9 October 2018:
A new perspectives paper by CNBP researcher Dr Ivan Maksymov, RMIT University discusses dielectric resonant systems and demonstrates their ability to operate as multiresonant antennas for light, microwaves, magnons, sound, vibrations and heat.
Journal: Journal of Applied Physics.
Publication title: Perspective: Strong microwave photon-magnon coupling in multiresonant dielectric antennas.
Author: Ivan S. Maksymov.
Abstract: Achieving quantum-level control over electromagnetic waves, magnetisation dynamics, vibrations, and heat is invaluable for many practical applications and possible by exploiting the strong radiation-matter coupling. Most of the modern strong microwave photon-magnon coupling developments rely on the integration of metal-based microwave resonators with a magnetic material. However, it has recently been realised that all-dielectric resonators made of or containing magneto-insulating materials can operate as a standalone strongly coupled system characterised by low dissipation losses and strong local microwave field enhancement. Here, after a brief overview of recent developments in the field, I discuss examples of such dielectric resonant systems and demonstrate their ability to operate as multiresonant antennas for light, microwaves, magnons, sound, vibrations, and heat. This multiphysics behavior opens up novel opportunities for the realisation of multiresonant coupling such as, for example, photon-magnon-phonon coupling. I also propose several novel systems in which strong photon-magnon coupling in dielectric antennas and similar structures is expected to extend the capability of existing devices or may provide an entirely new functionality. Examples of such systems include novel magnetofluidic devices, high-power microwave power generators, and hybrid devices exploiting the unique properties of electrical solitons.
9 October 2018:
CNBP has held a successful ‘Publications Masterclass’ for its PhD students, providing participants with a hands-on experience in preparing manuscripts for academic peer reviewed journals.
Hosted by Professor Andrew Greentree (RMIT) and Professor Tiffany Walsh at Deakin University, the two day masterclass (8-9th October) took 18 students through the publication writing process, provided tips on improving publication writing skills and included real time work-shopping of manuscripts.
“Feedback from the masterclass attendees was extremely positive with PhD students learning new skills and intending to integrate key learnings into their publications,” said masterclass coordinator, Kathy Nicholson, CNBP Chief Operating Officer.
“The residential nature of the two-day workshop also worked well and connected CNBP students from across University nodes helping build scientific relationships,” she said.
“Prof Greentree and Prof Walsh provided a wealth of knowledge and expertise which was the basis of this highly successful event.”
Below – Participants at the 2018 CNBP Publications Masterclass.
4 October 2018:
A new review paper by CNBP student Cheryl Suwen Law (University of Adelaide) & other CNBP coauthors provides a comprehensive and up-to-date collation of fundamental and applied developments of nanoporous anodic alumina photonic crystals as optical platforms for chemo- and biosensing applications.
Publication title: Nanoporous Anodic Alumina Photonic Crystals for Optical Chemo- and Biosensing: Fundamentals, Advances, and Perspectives.
Authors: Cheryl Suwen Law, Siew Yee Lim, Andrew D. Abell, Nicolas H. Voelcker and Abel Santos.
Abstract: Optical sensors are a class of devices that enable the identification and/or quantification of analyte molecules across multiple fields and disciplines such as environmental protection, medical diagnosis, security, food technology, biotechnology, and animal welfare. Nanoporous photonic crystal (PC) structures provide excellent platforms to develop such systems for a plethora of applications since these engineered materials enable precise and versatile control of light–matter interactions at the nanoscale. Nanoporous PCs provide both high sensitivity to monitor in real-time molecular binding events and a nanoporous matrix for selective immobilization of molecules of interest over increased surface areas. Nanoporous anodic alumina (NAA), a nanomaterial long envisaged as a PC, is an outstanding platform material to develop optical sensing systems in combination with multiple photonic technologies. Nanoporous anodic alumina photonic crystals (NAA-PCs) provide a versatile nanoporous structure that can be engineered in a multidimensional fashion to create unique PC sensing platforms such as Fabry–Pérot interferometers, distributed Bragg reflectors, gradient-index filters, optical microcavities, and others. The effective medium of NAA-PCs undergoes changes upon interactions with analyte molecules. These changes modify the NAA-PCs’ spectral fingerprints, which can be readily quantified to develop different sensing systems. This review introduces the fundamental development of NAA-PCs, compiling the most significant advances in the use of these optical materials for chemo- and biosensing applications, with a final prospective outlook about this exciting and dynamic field.
4 October 2018:
A new paper published in Scientific Reports demonstrates the feasibility of 3D printing of optical coherence tomography (OCT) fibre-optic probes. Lead author on the publication is CNBP’s Dr Jiawen Li (pictured).
Journal: Scientific Reports.
Publication title: Two-photon polymerisation 3D printed freeform micro-optics for optical coherence tomography fibre probes.
Authors: Jiawen Li, Peter Fejes, Dirk Lorenser, Bryden C. Quirk, Peter B. Noble, Rodney W. Kirk, Antony Orth, Fiona M. Wood, Brant C. Gibson, David D. Sampson & Robert A. McLaughlin.
Abstract: Miniaturised optical coherence tomography (OCT) fibre-optic probes have enabled high-resolution cross-sectional imaging deep within the body. However, existing OCT fibre-optic probe fabrication methods cannot generate miniaturised freeform optics, which limits our ability to fabricate probes with both complex optical function and dimensions comparable to the optical fibre diameter. Recently, major advances in two-photon direct laser writing have enabled 3D printing of arbitrary three-dimensional micro/nanostructures with a surface roughness acceptable for optical applications. Here, we demonstrate the feasibility of 3D printing of OCT probes. We evaluate the capability of this method based on a series of characterisation experiments. We report fabrication of a micro-optic containing an off-axis paraboloidal total internal reflecting surface, its integration as part of a common-path OCT probe, and demonstrate proof-of-principle imaging of biological samples.
3 October 2018:
Dr Yiqing Lu, CNBP Associate Investigator at Macquarie University, has taken out second place in the prestigious Centenary Institute Medical Innovation Awards.
The awards recognise the pursuits of young Australian researchers who are at the forefront of medical research.
For his work in developing a new nanocrystal powered optical imaging technique – to help detect multiple disease biomarkers in the body – Dr Lu received the Bayer Innovation Award and $15,000.
The money will be used to further support Dr Lu’s research in this advanced area of disease detection and diagnosis.
Further information on this innovative imaging technique can be accessed by clicking the following link here.
Below: Dr Yiqing Lu is presented with his award by Matt Kean, Minister for Innovation and Better Regulation (NSW State Government).
20 September 2018:
A class of Year 11 Physics students from Loreto College, Marryatville, South Australia were visited by CNBP researcher Dr Jiawen Li, September 20th, 2018.
During the outreach visit Dr Li spoke on the medical uses of fibre optics technology and answered questions from the class, helping shed light on the life of a scientist and explaining the wide-range of career options open to STEM students.
“I really enjoyed visiting the school and found the session an extremely rewarding experience,” said Dr Li.
“Student questions following the presentation were well thought through and hopefully I helped in some small way to encourage the girls to continue their study of physics and other STEM related subjects.”
“Higher education potentially opens up a wide range of exciting career opportunities right across the science, engineering and medical disciplines,” said Dr Li. “And it would be great to see these enthusiastic students get to University.”
Feedback from the school post-event noted that the students had found Dr Li to be a fantastic role model and that her presentation session had been particularly inspiring.
Below: Students from Loreto College at the outreach session.
10 September 2018:
A new paper with CNBP co-authors Prof Mark Hutchinson, Prof Ewa Goldys and Dr Guozhen Liu demonstrates an amperometric sensing device based on graphene oxide (GO) and structure-switching aptamers for long-term detection of cytokines in a living organism.
Journal: ACS Applied Materials and Interfaces.
Publication title: Graphene Oxide Based Recyclable in Vivo Device for Amperometric Monitoring of Interferon-γ in Inflammatory Mice.
Authors: Chaomin Cao, Ronghua Jin, Hui Wei, Wenchao Yang, Ewa M. Goldys, Mark R. Hutchinson, Shiyu Liu, Xin Chen, Guangfu Yang, and Guozhen Liu.
Abstract: Cytokine sensing is challenging due to their typically low abundances in physiological conditions. Nanomaterial fabricated interfaces demonstrated unique advantages in ultrasensitive sensing. Here, we demonstrate an amperometric sensing device based on graphene oxide (GO) and structure-switching aptamers for long-term detection of cytokines in a living organism. The device incorporates a single layer of GO acting as a signal amplifier on glassy carbon electrodes. The hairpin aptamers specific to interferon-γ (IFN-γ), which were loaded with redox probes, are covalently attached to GO to serve as biorecognition moieties. IFN-γ was able to trigger the configuration change of aptamers while releasing the trapped redox probes to introduce the electrochemical signal. This in vivo device was capable of quantitatively and dynamically detecting IFN-γ down to 1.3 pg mL–1 secreted by immune cells in cell culture medium with no baseline drift even at a high concentration of other nonspecific proteins. The biocompatible devices were also implanted into subcutaneous tissue of enteritis mice, where they performed precise detection of IFN-γ over 48 h without using physical barriers or active drift correction algorithms. Moreover, the device could be reused even after multiple rounds of regeneration of the sensing interface.
10 September 2018:
CNBP researchers have published a new trans-disciplinary review that reports on the Centre’s development of advanced optical fibre probes for use in biomedical sensing and imaging. The paper examines CNBP innovation through convergence of multiple science disciplines to generate opportunities for the fibre probes to address key challenges in real-time in vivo diagnostics. The lead author on the paper is Dr Jiawen Li (pictured).
Journal: APL Photonics.
Publication title: Perspective: Biomedical sensing and imaging with optical fibers—Innovation through convergence of science disciplines.
Authors: Jiawen Li, Heike Ebendorff-Heidepriem, Brant C. Gibson, Andrew D. Greentree, Mark R. Hutchinson, Peipei Jia, Roman Kostecki, Guozhen Liu, Antony Orth, Martin Ploschner, Erik P. Schartner, Stephen C. Warren-Smith, Kaixin Zhang, Georgios Tsiminis, and Ewa M. Goldys.
Abstract: The probing of physiological processes in living organisms is a grand challenge that requires bespoke analytical tools. Optical fiber probes offer a minimally invasive approach to report physiological signals from specific locations inside the body. This perspective article discusses a wide range of such fiber probes developed at the Australian Research Council Centre of Excellence for Nanoscale BioPhotonics. Our fiber platforms use a range of sensing modalities, including embedded nanodiamonds for magnetometry, interferometric fiber cavities for refractive index sensing, and tailored metal coatings for surface plasmon resonance sensing. Other fiber probes exploit molecularly sensitive Raman scattering or fluorescence where optical fibers have been combined with chemical and immunosensors. Fiber imaging probes based on interferometry and computational imaging are also discussed as emerging in vivo diagnostic devices. We provide examples to illustrate how the convergence of multiple scientific disciplines generates opportunities for the fiber probes to address key challenges in real-time in vivo diagnostics. These future fiber probes will enable the asking and answering of scientific questions that were never possible before.